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- Publisher Website: 10.1007/BF00053420
- Scopus: eid_2-s2.0-0025217279
- PMID: 2285653
- WOS: WOS:A1990CW23000002
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Conference Paper: Serotonergic antagonists and vascular disease
Title | Serotonergic antagonists and vascular disease |
---|---|
Authors | |
Keywords | adrenergic nerves atherosclerosis endothelium endothelium-derived contracting factor endothelium-derived relaxing factor hypertension regenerated endothelium serotonin |
Issue Date | 1990 |
Publisher | Springer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0920-3206 |
Citation | Cardiovascular Drugs And Therapy, 1990, v. 4 SUPPL. 1, p. 7-12 How to Cite? |
Abstract | 5-Hydroxytryptamine (serotonin) can evoke both contraction and relaxation of vascular smooth muscle. In disease, the constrictor component of the response to the monoamine appears to dominate. 5HT2-serotonergic antagonists favor dilatation, not only because they block the activating effect of serotonin on vascular smooth muscle, but also because they unmask the (endothelium-dependent) relaxation to the monoamine and brake the amplifying effect that it exerts on platelet aggregation. These properties of serotonergic antagonists help to explain their protective effects in vascular disease. |
Persistent Identifier | http://hdl.handle.net/10722/173476 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 0.973 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:32:15Z | - |
dc.date.available | 2012-10-30T06:32:15Z | - |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | Cardiovascular Drugs And Therapy, 1990, v. 4 SUPPL. 1, p. 7-12 | en_US |
dc.identifier.issn | 0920-3206 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/173476 | - |
dc.description.abstract | 5-Hydroxytryptamine (serotonin) can evoke both contraction and relaxation of vascular smooth muscle. In disease, the constrictor component of the response to the monoamine appears to dominate. 5HT2-serotonergic antagonists favor dilatation, not only because they block the activating effect of serotonin on vascular smooth muscle, but also because they unmask the (endothelium-dependent) relaxation to the monoamine and brake the amplifying effect that it exerts on platelet aggregation. These properties of serotonergic antagonists help to explain their protective effects in vascular disease. | en_US |
dc.language | eng | en_US |
dc.publisher | Springer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0920-3206 | en_US |
dc.relation.ispartof | Cardiovascular Drugs and Therapy | en_US |
dc.subject | adrenergic nerves | - |
dc.subject | atherosclerosis | - |
dc.subject | endothelium | - |
dc.subject | endothelium-derived contracting factor | - |
dc.subject | endothelium-derived relaxing factor | - |
dc.subject | hypertension | - |
dc.subject | regenerated endothelium | - |
dc.subject | serotonin | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Serotonin Antagonists - Therapeutic Use | en_US |
dc.subject.mesh | Vascular Diseases - Drug Therapy - Physiopathology | en_US |
dc.title | Serotonergic antagonists and vascular disease | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/BF00053420 | - |
dc.identifier.pmid | 2285653 | - |
dc.identifier.scopus | eid_2-s2.0-0025217279 | en_US |
dc.identifier.volume | 4 | en_US |
dc.identifier.issue | SUPPL. 1 | en_US |
dc.identifier.spage | 7 | en_US |
dc.identifier.epage | 12 | en_US |
dc.identifier.isi | WOS:A1990CW23000002 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0920-3206 | - |