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Conference Paper: Endothelium-dependent effects of beta-adrenergic blockers

TitleEndothelium-dependent effects of beta-adrenergic blockers
Authors
Vanhoutte, PM
Keywordsα-Adrenergic receptors
Acetylcholine
Carteolol
Endothelium-derived contracting factor
Endothelium-derived relaxing factor
Propranolol
Issue Date1990
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/JVR
Citation
Blood Vessels, 1990, v. 27 n. 2-5, p. 301-305 How to Cite?
AbstractNonselective β-adrenergic blockers have been reported to affect endothelium-dependent responses in isolated vessels in the following ways: (a) cause endothelium-augmented direct relaxation; (b) facilitate the endothelium-dependent relaxations evoked by α2-adrenergic activation, or by acetylcholine; (c) augment the intraluminal release of vasodilator prostanoids, and (d) inhibit endothelium-dependent contractions to anoxia. Important species differences exist in terms of the endothelium-dependent effects of the compounds. If they were to occur in the intact organism, the endothelium-dependent effects of the β-adrenergic blockers could help to explain their vasodilator properties.
Persistent Identifierhttp://hdl.handle.net/10722/173467
ISSN
0303-6847
ISI Accession Number ID
WOS:A1990EJ15600026

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:32:13Z-
dc.date.available2012-10-30T06:32:13Z-
dc.date.issued1990en_US
dc.identifier.citationBlood Vessels, 1990, v. 27 n. 2-5, p. 301-305en_US
dc.identifier.issn0303-6847en_US
dc.identifier.urihttp://hdl.handle.net/10722/173467-
dc.description.abstractNonselective β-adrenergic blockers have been reported to affect endothelium-dependent responses in isolated vessels in the following ways: (a) cause endothelium-augmented direct relaxation; (b) facilitate the endothelium-dependent relaxations evoked by α2-adrenergic activation, or by acetylcholine; (c) augment the intraluminal release of vasodilator prostanoids, and (d) inhibit endothelium-dependent contractions to anoxia. Important species differences exist in terms of the endothelium-dependent effects of the compounds. If they were to occur in the intact organism, the endothelium-dependent effects of the β-adrenergic blockers could help to explain their vasodilator properties.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/JVRen_US
dc.relation.ispartofBlood Vesselsen_US
dc.subjectα-Adrenergic receptors-
dc.subjectAcetylcholine-
dc.subjectCarteolol-
dc.subjectEndothelium-derived contracting factor-
dc.subjectEndothelium-derived relaxing factor-
dc.subjectPropranolol-
dc.subject.meshAdrenergic Beta-Antagonists - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEndothelium, Vascular - Drug Effectsen_US
dc.subject.meshMuscle Contractionen_US
dc.subject.meshNitric Oxide - Metabolismen_US
dc.titleEndothelium-dependent effects of beta-adrenergic blockersen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1978695-
dc.identifier.scopuseid_2-s2.0-0024997016en_US
dc.identifier.volume27en_US
dc.identifier.issue2-5en_US
dc.identifier.spage301en_US
dc.identifier.epage305en_US
dc.identifier.isiWOS:A1990EJ15600026-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.issnl0303-6847-

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