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Conference Paper: Effects of SIN-1 on electrical responses of the smooth muscle of the canine saphenous vein

TitleEffects of SIN-1 on electrical responses of the smooth muscle of the canine saphenous vein
Authors
Issue Date1989
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1989, v. 14 SUPPL. 11, p. S62-S66 How to Cite?
AbstractThe effects of SIN-1 were investigated on the electrical and mechanical properties of vascular smooth muscle cells of the canine saphenous vein. Isolated tissues with or without endothelium were contracted with norepinephrine, prostaglandin F(2α) or endothelin. SIN-1 and nitric oxide caused comparable concentration-dependent relaxations in rings with and without endothelium irrespective of the contracting agent. The relaxations to both SIN-1 and nitric oxide were inhibited by methylene blue. SIN-1 (up to 10-5 M) and nitric oxide (up to 10-5 M) did not alter membrane potential. The excitatory junction potentials and the slow depolarization generated by perivascular nerve stimulation were not affected by SIN-1 or nitric oxide. These results suggest that SIN-1 relaxes vascular smooth muscle by increasing the production of cyclic GMP without changing the membrane potential. In addition, SIN-1 does not modify peripheral adrenergic neurotransmission.
Persistent Identifierhttp://hdl.handle.net/10722/173462
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKomori, Ken_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:32:12Z-
dc.date.available2012-10-30T06:32:12Z-
dc.date.issued1989en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1989, v. 14 SUPPL. 11, p. S62-S66en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/173462-
dc.description.abstractThe effects of SIN-1 were investigated on the electrical and mechanical properties of vascular smooth muscle cells of the canine saphenous vein. Isolated tissues with or without endothelium were contracted with norepinephrine, prostaglandin F(2α) or endothelin. SIN-1 and nitric oxide caused comparable concentration-dependent relaxations in rings with and without endothelium irrespective of the contracting agent. The relaxations to both SIN-1 and nitric oxide were inhibited by methylene blue. SIN-1 (up to 10-5 M) and nitric oxide (up to 10-5 M) did not alter membrane potential. The excitatory junction potentials and the slow depolarization generated by perivascular nerve stimulation were not affected by SIN-1 or nitric oxide. These results suggest that SIN-1 relaxes vascular smooth muscle by increasing the production of cyclic GMP without changing the membrane potential. In addition, SIN-1 does not modify peripheral adrenergic neurotransmission.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDinoprost - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshEndothelins - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshMembrane Potentials - Drug Effectsen_US
dc.subject.meshMethylene Blue - Pharmacologyen_US
dc.subject.meshMolsidomine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Innervationen_US
dc.subject.meshNitric Oxide - Pharmacologyen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshSaphenous Vein - Drug Effects - Innervationen_US
dc.subject.meshSympathetic Nervous System - Drug Effectsen_US
dc.subject.meshSynaptic Transmission - Drug Effectsen_US
dc.subject.meshVasodilator Agents - Pharmacologyen_US
dc.titleEffects of SIN-1 on electrical responses of the smooth muscle of the canine saphenous veinen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2484702-
dc.identifier.scopuseid_2-s2.0-0024823311en_US
dc.identifier.volume14en_US
dc.identifier.issueSUPPL. 11en_US
dc.identifier.spageS62en_US
dc.identifier.epageS66en_US
dc.identifier.isiWOS:A1989EC14200011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKomori, K=8977740100en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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