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Conference Paper: Effects of SIN-1 on isolated canine basilar arteries

TitleEffects of SIN-1 on isolated canine basilar arteries
Authors
Issue Date1989
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1989, v. 14 SUPPL. 11, p. S72-S75 How to Cite?
AbstractThe effects of 3-morpholinosydnonimine (SIN-1) were studied in isolated canine basilar arteries. Rings with and without endothelium were suspended in Krebs-Ringer bicarbonate solution bubbled with 95% O2-5% CO2. Changes in isometric force were recorded. SIN-1, nitric oxide, and sodium nitroprusside caused concentration-dependent relaxations of control preparation contracted by uridine-5'-triphosphate. The removal of endothelium augmented the relaxation to the nitrovasodilators. Increasing concentrations of SIN-1 reduced endothelium-dependent contractions to the calcium ionophore A23127 and arachidonic acid. The results of the present study suggest that SIN-1 causes relaxation and prevents endothelium-dependent contractions in cerebral arteries. The inhibitory effect of SIN-1 is reduced by the presence of endothelium possibly by interaction with endothelium-derived relaxing factors and/or superoxide anions produced in endothelial cells. The inhibition of endothelium-dependent contractions could be due in part to chemical interactions between endothelium-derived contracting factor (superoxide anion) and the nitric oxide liberated by SIN-1.
Persistent Identifierhttp://hdl.handle.net/10722/173458
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKatusic, ZSen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:32:11Z-
dc.date.available2012-10-30T06:32:11Z-
dc.date.issued1989en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1989, v. 14 SUPPL. 11, p. S72-S75en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/173458-
dc.description.abstractThe effects of 3-morpholinosydnonimine (SIN-1) were studied in isolated canine basilar arteries. Rings with and without endothelium were suspended in Krebs-Ringer bicarbonate solution bubbled with 95% O2-5% CO2. Changes in isometric force were recorded. SIN-1, nitric oxide, and sodium nitroprusside caused concentration-dependent relaxations of control preparation contracted by uridine-5'-triphosphate. The removal of endothelium augmented the relaxation to the nitrovasodilators. Increasing concentrations of SIN-1 reduced endothelium-dependent contractions to the calcium ionophore A23127 and arachidonic acid. The results of the present study suggest that SIN-1 causes relaxation and prevents endothelium-dependent contractions in cerebral arteries. The inhibitory effect of SIN-1 is reduced by the presence of endothelium possibly by interaction with endothelium-derived relaxing factors and/or superoxide anions produced in endothelial cells. The inhibition of endothelium-dependent contractions could be due in part to chemical interactions between endothelium-derived contracting factor (superoxide anion) and the nitric oxide liberated by SIN-1.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBasilar Artery - Drug Effectsen_US
dc.subject.meshCyclic Gmp - Metabolismen_US
dc.subject.meshDogsen_US
dc.subject.meshMolsidomine - Analogs & Derivatives - Metabolism - Pharmacologyen_US
dc.subject.meshMuscle Relaxation - Drug Effectsen_US
dc.subject.meshNitric Oxide - Metabolism - Pharmacologyen_US
dc.subject.meshNitroprusside - Pharmacologyen_US
dc.subject.meshVasodilator Agents - Pharmacologyen_US
dc.titleEffects of SIN-1 on isolated canine basilar arteriesen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00005344-198914110-00013-
dc.identifier.pmid2484704-
dc.identifier.scopuseid_2-s2.0-0024799326en_US
dc.identifier.volume14en_US
dc.identifier.issueSUPPL. 11en_US
dc.identifier.spageS72en_US
dc.identifier.epageS75en_US
dc.identifier.isiWOS:A1989EC14200013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKatusic, ZS=7006971465en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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