File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: Endothelium-derived relaxing factor(s) and calcium antagonists

TitleEndothelium-derived relaxing factor(s) and calcium antagonists
Authors
Issue Date1989
PublisherDr Dietrich Steinkopff Verlag. The Journal's web site is located at http://www.springer.com/sgw/cda/frontpage/0,11855,4-10071-70-1061656-0,00.html?changeHeader=true
Citation
Zeitschrift Fur Kardiologie, 1989, v. 78 SUPPL. 6, p. 120-123 How to Cite?
AbstractThe presence of endothelium attenuates norepinephrine-induced vasoconstriction in the rat thoracic aorta by the spontaneous release of endothelium-derived relaxing factor. Calcium antagonists also inhibit catecholamine-induced vasoconstriction. Experiments were designed to determine the effect of calcium antagonists in the presence and absence of the endothelium on the responsiveness of the isolated rat aorta to norepinephrine. Rings of the thoracic aorta of Wistar Kyoto rats were suspended in organ chambers (in the presence of indomethacin) for isometric measurement of force. Mechanical removal of the endothelium shifted the concentration response curve to norepinephrine to the left and augmented the maximal response to the catecholamine. Diltiazem and verapamil shifted the concentration response curve to norepinephrine to the right only in rings without endothelium; they abolished the difference in sensitivites to norepinephrine caused by removal of the endothelium. Diltiazem, but not verapamil, also reduced the difference in the maximal response to norepinephrine. In the presence of oxyhemoglobin, diltiazem had similar effects on rings with and without endothelium. Sodium nitroprusside also abolished the hypersensitivity to norepinephrine caused by removal of the endothelium. These data suggest that calcium antagonists can prevent the hypersensitivity to norepinephrine in arteries in which the endothelium has been removed. They may explain some of the beneficial effects of calcium antagonists in conditions with endothelial dysfunction.
Persistent Identifierhttp://hdl.handle.net/10722/173456
ISSN
2007 Impact Factor: 0.971
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAuchSchwelk, Wen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:32:10Z-
dc.date.available2012-10-30T06:32:10Z-
dc.date.issued1989en_US
dc.identifier.citationZeitschrift Fur Kardiologie, 1989, v. 78 SUPPL. 6, p. 120-123en_US
dc.identifier.issn0300-5860en_US
dc.identifier.urihttp://hdl.handle.net/10722/173456-
dc.description.abstractThe presence of endothelium attenuates norepinephrine-induced vasoconstriction in the rat thoracic aorta by the spontaneous release of endothelium-derived relaxing factor. Calcium antagonists also inhibit catecholamine-induced vasoconstriction. Experiments were designed to determine the effect of calcium antagonists in the presence and absence of the endothelium on the responsiveness of the isolated rat aorta to norepinephrine. Rings of the thoracic aorta of Wistar Kyoto rats were suspended in organ chambers (in the presence of indomethacin) for isometric measurement of force. Mechanical removal of the endothelium shifted the concentration response curve to norepinephrine to the left and augmented the maximal response to the catecholamine. Diltiazem and verapamil shifted the concentration response curve to norepinephrine to the right only in rings without endothelium; they abolished the difference in sensitivites to norepinephrine caused by removal of the endothelium. Diltiazem, but not verapamil, also reduced the difference in the maximal response to norepinephrine. In the presence of oxyhemoglobin, diltiazem had similar effects on rings with and without endothelium. Sodium nitroprusside also abolished the hypersensitivity to norepinephrine caused by removal of the endothelium. These data suggest that calcium antagonists can prevent the hypersensitivity to norepinephrine in arteries in which the endothelium has been removed. They may explain some of the beneficial effects of calcium antagonists in conditions with endothelial dysfunction.en_US
dc.languageengen_US
dc.publisherDr Dietrich Steinkopff Verlag. The Journal's web site is located at http://www.springer.com/sgw/cda/frontpage/0,11855,4-10071-70-1061656-0,00.html?changeHeader=trueen_US
dc.relation.ispartofZeitschrift fur Kardiologieen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAorta, Thoracic - Drug Effectsen_US
dc.subject.meshCalcium Channel Blockers - Pharmacologyen_US
dc.subject.meshDiltiazem - Pharmacologyen_US
dc.subject.meshEndothelium, Vascular - Drug Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshNitric Oxide - Physiologyen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.subject.meshVerapamil - Pharmacologyen_US
dc.titleEndothelium-derived relaxing factor(s) and calcium antagonistsen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2618128-
dc.identifier.scopuseid_2-s2.0-0024451542en_US
dc.identifier.volume78en_US
dc.identifier.issueSUPPL. 6en_US
dc.identifier.spage120en_US
dc.identifier.epage123en_US
dc.identifier.isiWOS:A1989CE26200025-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridAuchSchwelk, W=7003395589en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats