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Conference Paper: The relationship of ventricular dynamics and mitochondrial nitric oxide synthase activity in septic shock models

TitleThe relationship of ventricular dynamics and mitochondrial nitric oxide synthase activity in septic shock models
Authors
Issue Date2005
Citation
The 27th Annual International Conference of the Engineering in Medicine and Biology Society (IEEE-EMBS 2005), Shanghai, China, 1-4 September 2005. In Conference Proceedings, 2005, v. 7, p. 2280-2282 How to Cite?
AbstractThe aim of the present study was to investigate the role of mitochondrial nitric oxide synthase (mtNOS) in the septic shock and analyze its relationship to ventricular contractility. Two models of septic shock [lipopolysaccharide (LPS)-induced and cecal ligation and puncture (CLP)-induced] were used. There was a significant depression of ventricular contractile parameters recorded in the late stage of the septic shock. After measurement of ventricular-dynamic parameters, mitochondrial and cytoplasmic fractions were isolated and their nitric oxide synthase (NOS) activity was assessed using a NOS activity assay kit Both models showed a larger increase in mitochondrial NOS activity than that in cytosol. However, the increase in mtNOS activity in the LPS-induced shock model was less pronounced than in the CLP-induced model. Regression analysis shows that mitochondrial nitric oxide sunthase (mtNOS) activity is negatively correlative to the left ventricular developed pressure in CLP model. The results suggest that mitochondrial NOS may mainly contribute to the ventricular depression in the septic shock. © 2005 IEEE.
Persistent Identifierhttp://hdl.handle.net/10722/173447
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorXu, Cen_US
dc.contributor.authorYe, Zen_US
dc.contributor.authorGao, Qen_US
dc.contributor.authorShan, Qen_US
dc.contributor.authorBourreau, JPen_US
dc.contributor.authorXia, Qen_US
dc.date.accessioned2012-10-30T06:31:28Z-
dc.date.available2012-10-30T06:31:28Z-
dc.date.issued2005en_US
dc.identifier.citationThe 27th Annual International Conference of the Engineering in Medicine and Biology Society (IEEE-EMBS 2005), Shanghai, China, 1-4 September 2005. In Conference Proceedings, 2005, v. 7, p. 2280-2282en_US
dc.identifier.issn0589-1019en_US
dc.identifier.urihttp://hdl.handle.net/10722/173447-
dc.description.abstractThe aim of the present study was to investigate the role of mitochondrial nitric oxide synthase (mtNOS) in the septic shock and analyze its relationship to ventricular contractility. Two models of septic shock [lipopolysaccharide (LPS)-induced and cecal ligation and puncture (CLP)-induced] were used. There was a significant depression of ventricular contractile parameters recorded in the late stage of the septic shock. After measurement of ventricular-dynamic parameters, mitochondrial and cytoplasmic fractions were isolated and their nitric oxide synthase (NOS) activity was assessed using a NOS activity assay kit Both models showed a larger increase in mitochondrial NOS activity than that in cytosol. However, the increase in mtNOS activity in the LPS-induced shock model was less pronounced than in the CLP-induced model. Regression analysis shows that mitochondrial nitric oxide sunthase (mtNOS) activity is negatively correlative to the left ventricular developed pressure in CLP model. The results suggest that mitochondrial NOS may mainly contribute to the ventricular depression in the septic shock. © 2005 IEEE.en_US
dc.languageengen_US
dc.relation.ispartofAlliance for Engineering in Medicine and Biology. Proceedings of the Annual Conferenceen_US
dc.titleThe relationship of ventricular dynamics and mitochondrial nitric oxide synthase activity in septic shock modelsen_US
dc.typeConference_Paperen_US
dc.identifier.emailBourreau, JP:bourreau@hkucc.hku.hken_US
dc.identifier.authorityBourreau, JP=rp00389en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-33846914265en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846914265&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume7en_US
dc.identifier.spage2280en_US
dc.identifier.epage2282en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridXu, C=37119571900en_US
dc.identifier.scopusauthoridYe, Z=7401956920en_US
dc.identifier.scopusauthoridGao, Q=7202743823en_US
dc.identifier.scopusauthoridShan, Q=7007145043en_US
dc.identifier.scopusauthoridBourreau, JP=7003927886en_US
dc.identifier.scopusauthoridXia, Q=7202871577en_US
dc.customcontrol.immutablesml 160602 amended-

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