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- Scopus: eid_2-s2.0-0030778115
- PMID: 9406665
- WOS: WOS:A1997YJ03600012
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Article: Local hypoxia does not elevate adenosine output from isolated gracilis muscle in anaesthetized dogs
Title | Local hypoxia does not elevate adenosine output from isolated gracilis muscle in anaesthetized dogs |
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Authors | |
Keywords | Adenosine Hypoxia Lactate |
Issue Date | 1997 |
Publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP |
Citation | Clinical And Experimental Pharmacology And Physiology, 1997, v. 24 n. 12, p. 963-965 How to Cite? |
Abstract | 1. The influence of local hypoxia on adenosine and lactate output from isolated perfused gracilis muscle was studied in anesthetized dogs. 2. Oxygen tension in the arterial blood supplying the muscle was reduced by a membrane lung from 145.9 ± 28.9 to 52.9 ± 2.6 (moderate hypoxia) or 30.0 ± 1.2 mmHg (severe hypoxia). 3. Moderate hypoxia did not significantly alter vascular resistance, but severe hypoxia reduced arterial perfusion pressure from 199.0 ± 13.6 to 122.6 ± 8.7 mmHg, 4. Veno-arterial (V-A) lactate was 0.47 ± 0.13 mmol/L in normoxia neither level of hypoxia changed it significantly, Veno-arterial adenosine was 74 ± 78 nmol/L in normoxia, Moderate hypoxia decreased this to -36 ± 59 nmol/L (P < 0.05), but the level of V-A adenosine in severe hypoxia (52 ± 96 nmol/L) was similar to that in normoxia. 5. These data confirm that hypoxia does not directly stimulate adenosine output from oxidative skeletal muscle. |
Persistent Identifier | http://hdl.handle.net/10722/173440 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.610 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Ballard, HJ | en_US |
dc.date.accessioned | 2012-10-30T06:31:25Z | - |
dc.date.available | 2012-10-30T06:31:25Z | - |
dc.date.issued | 1997 | en_US |
dc.identifier.citation | Clinical And Experimental Pharmacology And Physiology, 1997, v. 24 n. 12, p. 963-965 | en_US |
dc.identifier.issn | 0305-1870 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/173440 | - |
dc.description.abstract | 1. The influence of local hypoxia on adenosine and lactate output from isolated perfused gracilis muscle was studied in anesthetized dogs. 2. Oxygen tension in the arterial blood supplying the muscle was reduced by a membrane lung from 145.9 ± 28.9 to 52.9 ± 2.6 (moderate hypoxia) or 30.0 ± 1.2 mmHg (severe hypoxia). 3. Moderate hypoxia did not significantly alter vascular resistance, but severe hypoxia reduced arterial perfusion pressure from 199.0 ± 13.6 to 122.6 ± 8.7 mmHg, 4. Veno-arterial (V-A) lactate was 0.47 ± 0.13 mmol/L in normoxia neither level of hypoxia changed it significantly, Veno-arterial adenosine was 74 ± 78 nmol/L in normoxia, Moderate hypoxia decreased this to -36 ± 59 nmol/L (P < 0.05), but the level of V-A adenosine in severe hypoxia (52 ± 96 nmol/L) was similar to that in normoxia. 5. These data confirm that hypoxia does not directly stimulate adenosine output from oxidative skeletal muscle. | en_US |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP | en_US |
dc.relation.ispartof | Clinical and Experimental Pharmacology and Physiology | en_US |
dc.subject | Adenosine | - |
dc.subject | Hypoxia | - |
dc.subject | Lactate | - |
dc.subject.mesh | Adenosine - Metabolism | en_US |
dc.subject.mesh | Anesthesia | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Cell Hypoxia - Physiology | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Lactose - Metabolism | en_US |
dc.subject.mesh | Muscle, Skeletal - Blood Supply - Metabolism | en_US |
dc.subject.mesh | Oxygen - Blood - Metabolism | en_US |
dc.subject.mesh | Partial Pressure | en_US |
dc.subject.mesh | Vasodilation - Physiology | en_US |
dc.title | Local hypoxia does not elevate adenosine output from isolated gracilis muscle in anaesthetized dogs | en_US |
dc.type | Article | en_US |
dc.identifier.email | Ballard, HJ:ballard@hkucc.hku.hk | en_US |
dc.identifier.authority | Ballard, HJ=rp00367 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 9406665 | - |
dc.identifier.scopus | eid_2-s2.0-0030778115 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0030778115&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 24 | en_US |
dc.identifier.issue | 12 | en_US |
dc.identifier.spage | 963 | en_US |
dc.identifier.epage | 965 | en_US |
dc.identifier.isi | WOS:A1997YJ03600012 | - |
dc.publisher.place | Australia | en_US |
dc.identifier.scopusauthorid | Ballard, HJ=7005286310 | en_US |
dc.identifier.issnl | 0305-1870 | - |