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Article: Local hypoxia does not elevate adenosine output from isolated gracilis muscle in anaesthetized dogs

TitleLocal hypoxia does not elevate adenosine output from isolated gracilis muscle in anaesthetized dogs
Authors
Issue Date1997
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP
Citation
Clinical And Experimental Pharmacology And Physiology, 1997, v. 24 n. 12, p. 963-965 How to Cite?
Abstract1. The influence of local hypoxia on adenosine and lactate output from isolated perfused gracilis muscle was studied in anesthetized dogs. 2. Oxygen tension in the arterial blood supplying the muscle was reduced by a membrane lung from 145.9 ± 28.9 to 52.9 ± 2.6 (moderate hypoxia) or 30.0 ± 1.2 mmHg (severe hypoxia). 3. Moderate hypoxia did not significantly alter vascular resistance, but severe hypoxia reduced arterial perfusion pressure from 199.0 ± 13.6 to 122.6 ± 8.7 mmHg, 4. Veno-arterial (V-A) lactate was 0.47 ± 0.13 mmol/L in normoxia neither level of hypoxia changed it significantly, Veno-arterial adenosine was 74 ± 78 nmol/L in normoxia, Moderate hypoxia decreased this to -36 ± 59 nmol/L (P < 0.05), but the level of V-A adenosine in severe hypoxia (52 ± 96 nmol/L) was similar to that in normoxia. 5. These data confirm that hypoxia does not directly stimulate adenosine output from oxidative skeletal muscle.
Persistent Identifierhttp://hdl.handle.net/10722/173440
ISSN
2012 Impact Factor: 2.16
2015 SCImago Journal Rankings: 0.944
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBallard, HJen_US
dc.date.accessioned2012-10-30T06:31:25Z-
dc.date.available2012-10-30T06:31:25Z-
dc.date.issued1997en_US
dc.identifier.citationClinical And Experimental Pharmacology And Physiology, 1997, v. 24 n. 12, p. 963-965en_US
dc.identifier.issn0305-1870en_US
dc.identifier.urihttp://hdl.handle.net/10722/173440-
dc.description.abstract1. The influence of local hypoxia on adenosine and lactate output from isolated perfused gracilis muscle was studied in anesthetized dogs. 2. Oxygen tension in the arterial blood supplying the muscle was reduced by a membrane lung from 145.9 ± 28.9 to 52.9 ± 2.6 (moderate hypoxia) or 30.0 ± 1.2 mmHg (severe hypoxia). 3. Moderate hypoxia did not significantly alter vascular resistance, but severe hypoxia reduced arterial perfusion pressure from 199.0 ± 13.6 to 122.6 ± 8.7 mmHg, 4. Veno-arterial (V-A) lactate was 0.47 ± 0.13 mmol/L in normoxia neither level of hypoxia changed it significantly, Veno-arterial adenosine was 74 ± 78 nmol/L in normoxia, Moderate hypoxia decreased this to -36 ± 59 nmol/L (P < 0.05), but the level of V-A adenosine in severe hypoxia (52 ± 96 nmol/L) was similar to that in normoxia. 5. These data confirm that hypoxia does not directly stimulate adenosine output from oxidative skeletal muscle.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEPen_US
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologyen_US
dc.subject.meshAdenosine - Metabolismen_US
dc.subject.meshAnesthesiaen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Hypoxia - Physiologyen_US
dc.subject.meshDogsen_US
dc.subject.meshLactose - Metabolismen_US
dc.subject.meshMuscle, Skeletal - Blood Supply - Metabolismen_US
dc.subject.meshOxygen - Blood - Metabolismen_US
dc.subject.meshPartial Pressureen_US
dc.subject.meshVasodilation - Physiologyen_US
dc.titleLocal hypoxia does not elevate adenosine output from isolated gracilis muscle in anaesthetized dogsen_US
dc.typeArticleen_US
dc.identifier.emailBallard, HJ:ballard@hkucc.hku.hken_US
dc.identifier.authorityBallard, HJ=rp00367en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9406665-
dc.identifier.scopuseid_2-s2.0-0030778115en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030778115&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume24en_US
dc.identifier.issue12en_US
dc.identifier.spage963en_US
dc.identifier.epage965en_US
dc.identifier.isiWOS:A1997YJ03600012-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridBallard, HJ=7005286310en_US

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