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Article: Glycodelin-A modulates syncytialization of human BeWo choriocarcinoma cell line

TitleGlycodelin-A modulates syncytialization of human BeWo choriocarcinoma cell line
Authors
KeywordsDifferentiation
Fusion
Glycodelin
Human trophoblast
Invasion
Issue Date2012
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/placenta
Citation
Placenta, 2012, v. 33 n. 9, p. 750-752 How to Cite?
AbstractCytotrophoblasts are the key trophoblast cells which differentiate into different trophoblast lineages. In this report, glycodelin-A action on fusion of a cytotrophoblast-like cell line (BeWo) was investigated. It significantly reduced the spontaneous fusion of BeWo cells. The treatment enhanced the invasion and extracellular-signal regulated kinases activation of BeWo cells. The mRNA expression of syncytialization markers, human chorionic gonadotrophin and glial cells missing homolog 1 were suppressed upon glycodelin-A treatment. The data suggest a possible function of glycodelin-A in mediating cytotrophoblast differentiation. Crown Copyright © 2012 Published by Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/173377
ISSN
2015 Impact Factor: 2.972
2015 SCImago Journal Rankings: 1.608
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, KKWen_HK
dc.contributor.authorPang, RTKen_HK
dc.contributor.authorLee, CLen_HK
dc.contributor.authorKoistinen, Hen_HK
dc.contributor.authorSeppala, Men_HK
dc.contributor.authorHo, PCen_HK
dc.contributor.authorYeung, WSBen_HK
dc.contributor.authorChiu, PCNen_HK
dc.date.accessioned2012-10-30T06:29:49Z-
dc.date.available2012-10-30T06:29:49Z-
dc.date.issued2012en_HK
dc.identifier.citationPlacenta, 2012, v. 33 n. 9, p. 750-752en_HK
dc.identifier.issn0143-4004en_HK
dc.identifier.urihttp://hdl.handle.net/10722/173377-
dc.description.abstractCytotrophoblasts are the key trophoblast cells which differentiate into different trophoblast lineages. In this report, glycodelin-A action on fusion of a cytotrophoblast-like cell line (BeWo) was investigated. It significantly reduced the spontaneous fusion of BeWo cells. The treatment enhanced the invasion and extracellular-signal regulated kinases activation of BeWo cells. The mRNA expression of syncytialization markers, human chorionic gonadotrophin and glial cells missing homolog 1 were suppressed upon glycodelin-A treatment. The data suggest a possible function of glycodelin-A in mediating cytotrophoblast differentiation. Crown Copyright © 2012 Published by Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_US
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/placentaen_HK
dc.relation.ispartofPlacentaen_HK
dc.subjectDifferentiationen_HK
dc.subjectFusionen_HK
dc.subjectGlycodelinen_HK
dc.subjectHuman trophoblasten_HK
dc.subjectInvasionen_HK
dc.titleGlycodelin-A modulates syncytialization of human BeWo choriocarcinoma cell lineen_HK
dc.typeArticleen_HK
dc.identifier.emailPang, RTK: rtkpang@hku.hken_HK
dc.identifier.emailHo, PC: pcho@hku.hken_HK
dc.identifier.emailChiu, PCN: pchiucn@hku.hken_HK
dc.identifier.authorityPang, RTK=rp01761en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.identifier.authorityChiu, PCN=rp00424en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.placenta.2012.06.001en_HK
dc.identifier.pmid22748851-
dc.identifier.scopuseid_2-s2.0-84865230615en_HK
dc.identifier.hkuros209697-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84865230615&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue9en_HK
dc.identifier.spage750en_HK
dc.identifier.epage752en_HK
dc.identifier.isiWOS:000308896300014-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLam, KKW=25637362300en_HK
dc.identifier.scopusauthoridPang, RTK=7004376636en_HK
dc.identifier.scopusauthoridLee, CL=9277221100en_HK
dc.identifier.scopusauthoridKoistinen, H=7003612125en_HK
dc.identifier.scopusauthoridSeppala, M=35475165300en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK
dc.identifier.scopusauthoridYeung, WSB=55763794967en_HK
dc.identifier.scopusauthoridChiu, PCN=25959969200en_HK

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