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Article: Anti-Parkinsonian drug discovery from herbal medicines: What have we got from neurotoxic models?

TitleAnti-Parkinsonian drug discovery from herbal medicines: What have we got from neurotoxic models?
Authors
KeywordsHerbal medicines
Neuroprotection
Neurotoxins
Parkinson's disease
Issue Date2012
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jethpharm
Citation
Journal Of Ethnopharmacology, 2012, v. 139 n. 3, p. 698-711 How to Cite?
AbstractEthnopharmacological relevance: Herbal medicines are used to treat Parkinson's disease (PD) in ancient medical systems in Asian countries such as India, China, Japan and Korea based on their own anecdotal or experience-based theories. Aim of the review: To systematically summarize and analyze the anti-Parkinsonian activities of herbal preparations (including active compounds, herbal extracts and formulations) investigated in the neurotoxic models of PD and provide future references for basic and clinical investigations. Materials and methods: All the herbal materials tested on in vitro and in vivo neurotoxic models of PD were retrieved from PubMed database by using pre-set searching strings. The relevant compounds and herbal extracts with anti-Parkinsonian activities were included and analyzed according to their chemical classifications or biological activities. Results: A total of 51 herbal medicines were analyzed. A diversity of compounds isolated from herbal materials were reported to be effective on neurotoxic models of PD by modulating multiple key events or signaling pathways implicated in the pathogenesis of PD. The main structure types of these compounds belong to catechols, stilbenoids, flavonoids, phenylpropanoids and lignans, phenylethanoid glycosides and terpenes. Although some herbal extracts and formulations have shown positive results on PD animal models, the relative compounds accounting for the effects and the underlying mechanisms remain to be further investigated. Conclusions: Herbal medicines can be an alternative and valuable source for anti-Parkinsonian drug discovery. Compounds classified into stilbenoids, flavonoids, catechols and terpenes may be the most promising candidates for further investigation. Some well-studies compounds such as baicalein, puerarin, resveratrol, curcumin and ginsenosides deserve further consideration in clinical trials. In-depth experimental studies are still needed to evaluate the efficacy of herbal extracts and formulations in PD models. © 2011 Elsevier Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/173371
ISSN
2015 Impact Factor: 3.055
2015 SCImago Journal Rankings: 1.156
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSong, JXen_HK
dc.contributor.authorSze, SCWen_HK
dc.contributor.authorNg, TBen_HK
dc.contributor.authorLee, CKFen_HK
dc.contributor.authorLeung, GPHen_HK
dc.contributor.authorShaw, PCen_HK
dc.contributor.authorTong, Yen_HK
dc.contributor.authorZhang, YBen_HK
dc.date.accessioned2012-10-30T06:29:42Z-
dc.date.available2012-10-30T06:29:42Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of Ethnopharmacology, 2012, v. 139 n. 3, p. 698-711en_HK
dc.identifier.issn0378-8741en_HK
dc.identifier.urihttp://hdl.handle.net/10722/173371-
dc.description.abstractEthnopharmacological relevance: Herbal medicines are used to treat Parkinson's disease (PD) in ancient medical systems in Asian countries such as India, China, Japan and Korea based on their own anecdotal or experience-based theories. Aim of the review: To systematically summarize and analyze the anti-Parkinsonian activities of herbal preparations (including active compounds, herbal extracts and formulations) investigated in the neurotoxic models of PD and provide future references for basic and clinical investigations. Materials and methods: All the herbal materials tested on in vitro and in vivo neurotoxic models of PD were retrieved from PubMed database by using pre-set searching strings. The relevant compounds and herbal extracts with anti-Parkinsonian activities were included and analyzed according to their chemical classifications or biological activities. Results: A total of 51 herbal medicines were analyzed. A diversity of compounds isolated from herbal materials were reported to be effective on neurotoxic models of PD by modulating multiple key events or signaling pathways implicated in the pathogenesis of PD. The main structure types of these compounds belong to catechols, stilbenoids, flavonoids, phenylpropanoids and lignans, phenylethanoid glycosides and terpenes. Although some herbal extracts and formulations have shown positive results on PD animal models, the relative compounds accounting for the effects and the underlying mechanisms remain to be further investigated. Conclusions: Herbal medicines can be an alternative and valuable source for anti-Parkinsonian drug discovery. Compounds classified into stilbenoids, flavonoids, catechols and terpenes may be the most promising candidates for further investigation. Some well-studies compounds such as baicalein, puerarin, resveratrol, curcumin and ginsenosides deserve further consideration in clinical trials. In-depth experimental studies are still needed to evaluate the efficacy of herbal extracts and formulations in PD models. © 2011 Elsevier Ireland Ltd.en_HK
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jethpharmen_HK
dc.relation.ispartofJournal of Ethnopharmacologyen_HK
dc.subjectHerbal medicinesen_HK
dc.subjectNeuroprotectionen_HK
dc.subjectNeurotoxinsen_HK
dc.subjectParkinson's diseaseen_HK
dc.subject.meshDrug Discoveryen_US
dc.subject.meshHumansen_US
dc.subject.meshModels, Neurologicalen_US
dc.subject.meshNeurotoxicity Syndromes - Drug Therapyen_US
dc.subject.meshParkinson Disease - Drug Therapyen_US
dc.subject.meshPhytotherapyen_US
dc.subject.meshPlant Preparations - Therapeutic Useen_US
dc.subject.meshPlants, Medicinal - Chemistryen_US
dc.titleAnti-Parkinsonian drug discovery from herbal medicines: What have we got from neurotoxic models?en_HK
dc.typeArticleen_HK
dc.identifier.emailSze, SCW: stephens@hku.hken_HK
dc.identifier.emailLee, CKF: ckflee@hku.hken_HK
dc.identifier.emailLeung, GPH: gphleung@hkucc.hku.hken_HK
dc.identifier.emailTong, Y: tongyao@hku.hken_HK
dc.identifier.emailZhang, YB: ybzhang@hku.hken_HK
dc.identifier.authoritySze, SCW=rp00514en_HK
dc.identifier.authorityLee, CKF=rp00458en_HK
dc.identifier.authorityLeung, GPH=rp00234en_HK
dc.identifier.authorityTong, Y=rp00509en_HK
dc.identifier.authorityZhang, YB=rp01410en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.jep.2011.12.030en_HK
dc.identifier.pmid22212501-
dc.identifier.scopuseid_2-s2.0-84856225515en_HK
dc.identifier.hkuros202968-
dc.identifier.hkuros217964-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84856225515&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume139en_HK
dc.identifier.issue3en_HK
dc.identifier.spage698en_HK
dc.identifier.epage711en_HK
dc.identifier.isiWOS:000301900400007-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridSong, JX=24339343800en_HK
dc.identifier.scopusauthoridSze, SCW=23482617000en_HK
dc.identifier.scopusauthoridNg, TB=35311803300en_HK
dc.identifier.scopusauthoridLee, CKF=26643097500en_HK
dc.identifier.scopusauthoridLeung, GPH=35963668200en_HK
dc.identifier.scopusauthoridShaw, PC=35599523600en_HK
dc.identifier.scopusauthoridTong, Y=9045384000en_HK
dc.identifier.scopusauthoridZhang, YB=23483121900en_HK
dc.identifier.citeulike10186655-

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