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Article: Interleukin-10 promoter polymorphisms in Southern Chinese patients with systemic lupus erythematosus

TitleInterleukin-10 promoter polymorphisms in Southern Chinese patients with systemic lupus erythematosus
Authors
Issue Date1998
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0004-3591/
Citation
Arthritis And Rheumatism, 1998, v. 41 n. 6, p. 1090-1095 How to Cite?
AbstractObjective. To study the genetic association of interleukin-10 (IL-10) promoter polymorphisms in Southern Chinese patients with systemic lupus erythematosus (SLE), and to investigate possible associations with clinical manifestations of the disease. Methods. DNA was extracted from 88 Chinese patients with SLE and 83 ethnically matched controls. The IL-10 promoter region between positions -533 and -1120 was amplified by polymerase chain reaction, and polymorphisms were detected by restriction-enzyme cleavage. Results. No significant difference in the allele or haplotype frequencies between SLE patients and controls could be demonstrated. The *A and *C alleles at the -597 position were linked to the *T and *C alleles at the - 824 position, respectively. However, when clinical features were examined, the *A allele at the -597 position and the *T allele at the -824 position were significantly associated with lupus nephritis, by chisquare analysis (P < 0.001, odds ratio 4.19, 95% confidence interval 2.02-8.71). Similarly, the haplotype -1087*A/-824*T/-597*A was also associated with renal involvement (P < 0.001, odds ratio 3.62, 95% confidence interval 1.80-7.31). Conclusion. IL- 10 promoter polymorphisms are not strong determinants of susceptibility to the development of SLE, per se, in Southern Chinese individuals. However, IL- 10 genotypes are strongly associated with certain clinical manifestations of SLE and may have a role in predicting disease prognosis.
Persistent Identifierhttp://hdl.handle.net/10722/173296
ISSN
2015 Impact Factor: 8.955
2015 SCImago Journal Rankings: 3.206
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMok, CCen_US
dc.contributor.authorLanchbury, JSen_US
dc.contributor.authorChan, DWen_US
dc.contributor.authorLau, CSen_US
dc.date.accessioned2012-10-30T06:29:09Z-
dc.date.available2012-10-30T06:29:09Z-
dc.date.issued1998en_US
dc.identifier.citationArthritis And Rheumatism, 1998, v. 41 n. 6, p. 1090-1095en_US
dc.identifier.issn0004-3591en_US
dc.identifier.urihttp://hdl.handle.net/10722/173296-
dc.description.abstractObjective. To study the genetic association of interleukin-10 (IL-10) promoter polymorphisms in Southern Chinese patients with systemic lupus erythematosus (SLE), and to investigate possible associations with clinical manifestations of the disease. Methods. DNA was extracted from 88 Chinese patients with SLE and 83 ethnically matched controls. The IL-10 promoter region between positions -533 and -1120 was amplified by polymerase chain reaction, and polymorphisms were detected by restriction-enzyme cleavage. Results. No significant difference in the allele or haplotype frequencies between SLE patients and controls could be demonstrated. The *A and *C alleles at the -597 position were linked to the *T and *C alleles at the - 824 position, respectively. However, when clinical features were examined, the *A allele at the -597 position and the *T allele at the -824 position were significantly associated with lupus nephritis, by chisquare analysis (P < 0.001, odds ratio 4.19, 95% confidence interval 2.02-8.71). Similarly, the haplotype -1087*A/-824*T/-597*A was also associated with renal involvement (P < 0.001, odds ratio 3.62, 95% confidence interval 1.80-7.31). Conclusion. IL- 10 promoter polymorphisms are not strong determinants of susceptibility to the development of SLE, per se, in Southern Chinese individuals. However, IL- 10 genotypes are strongly associated with certain clinical manifestations of SLE and may have a role in predicting disease prognosis.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0004-3591/en_US
dc.relation.ispartofArthritis and Rheumatismen_US
dc.subject.meshAdulten_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshAutoantibodies - Analysis - Geneticsen_US
dc.subject.meshChina - Ethnologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHaplotypes - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshInterleukin-10 - Geneticsen_US
dc.subject.meshLupus Erythematosus, Systemic - Ethnology - Genetics - Physiopathologyen_US
dc.subject.meshLupus Nephritis - Genetics - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPolymorphism, Genetic - Geneticsen_US
dc.subject.meshPromoter Regions, Genetic - Geneticsen_US
dc.titleInterleukin-10 promoter polymorphisms in Southern Chinese patients with systemic lupus erythematosusen_US
dc.typeArticleen_US
dc.identifier.emailChan, DW:dwchan@hkucc.hku.hken_US
dc.identifier.emailLau, CS:cslau@hku.hken_US
dc.identifier.authorityChan, DW=rp00543en_US
dc.identifier.authorityLau, CS=rp01348en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/1529-0131(199806)41:6<1090::AID-ART16>3.0.CO;2-6en_US
dc.identifier.pmid9627019-
dc.identifier.scopuseid_2-s2.0-2942643251en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2942643251&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume41en_US
dc.identifier.issue6en_US
dc.identifier.spage1090en_US
dc.identifier.epage1095en_US
dc.identifier.isiWOS:000074023700015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMok, CC=34668219600en_US
dc.identifier.scopusauthoridLanchbury, JS=7004804446en_US
dc.identifier.scopusauthoridChan, DW=26533900600en_US
dc.identifier.scopusauthoridLau, CS=14035682100en_US

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