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Article: The influence of fetal sex in screening for trisomy 21 by fetal nuchal translucency, maternal serum free β-hCG and PAPP-A at 10-14 weeks of gestation

TitleThe influence of fetal sex in screening for trisomy 21 by fetal nuchal translucency, maternal serum free β-hCG and PAPP-A at 10-14 weeks of gestation
Authors
Issue Date2000
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 2000, v. 20 n. 8, p. 673-675 How to Cite?
AbstractIn a study of 2923 normal pregnancies and 203 pregnancies affected by trisomy 21 we have shown a significant difference in the median MoM of the markers: fetal nuchal translucency, maternal serum free β-hCG and PAPP-A in the presence of a female fetus compared with a male fetus. For maternal serum free β-hCG levels are higher by 15% if the fetus is chromosomally normal and by 11% if the fetus has trisomy 21. For maternal serum PAPP-A the levels in chromosomally normal fetuses are 10% higher in the presence of a female fetus and 13%, higher if the fetus has trisomy 21. In contrast, fetal nuchal translucency is 3-4% lower in both chromosomally normal and trisomy 21 female fetuses. The consequence of such changes when screening for trisomy 21 will be a reduction in the detection rate in female fetuses by a factor of 1-2%. Correction of risk algorithms for fetal sex, however, is probably not feasible, since ultrasound detection of fetal sex is only 70-90%, accurate in the 10-14 week period. Copyright (C) 2000 John Wiley and Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/173241
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
References

 

DC FieldValueLanguage
dc.contributor.authorSpencer, Ken_US
dc.contributor.authorOng, CYTen_US
dc.contributor.authorLiao, AWJen_US
dc.contributor.authorPapademetriou, Den_US
dc.contributor.authorNicolaides, KHen_US
dc.date.accessioned2012-10-30T06:28:44Z-
dc.date.available2012-10-30T06:28:44Z-
dc.date.issued2000en_US
dc.identifier.citationPrenatal Diagnosis, 2000, v. 20 n. 8, p. 673-675en_US
dc.identifier.issn0197-3851en_US
dc.identifier.urihttp://hdl.handle.net/10722/173241-
dc.description.abstractIn a study of 2923 normal pregnancies and 203 pregnancies affected by trisomy 21 we have shown a significant difference in the median MoM of the markers: fetal nuchal translucency, maternal serum free β-hCG and PAPP-A in the presence of a female fetus compared with a male fetus. For maternal serum free β-hCG levels are higher by 15% if the fetus is chromosomally normal and by 11% if the fetus has trisomy 21. For maternal serum PAPP-A the levels in chromosomally normal fetuses are 10% higher in the presence of a female fetus and 13%, higher if the fetus has trisomy 21. In contrast, fetal nuchal translucency is 3-4% lower in both chromosomally normal and trisomy 21 female fetuses. The consequence of such changes when screening for trisomy 21 will be a reduction in the detection rate in female fetuses by a factor of 1-2%. Correction of risk algorithms for fetal sex, however, is probably not feasible, since ultrasound detection of fetal sex is only 70-90%, accurate in the 10-14 week period. Copyright (C) 2000 John Wiley and Sons, Ltd.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_US
dc.relation.ispartofPrenatal Diagnosisen_US
dc.rightsPrenatal Diagnosis. Copyright © John Wiley & Sons Ltd.-
dc.subject.meshAdulten_US
dc.subject.meshChorionic Gonadotropin, Beta Subunit, Human - Blooden_US
dc.subject.meshDown Syndrome - Blood - Diagnosis - Ultrasonographyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshNeck - Embryology - Ultrasonographyen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy-Associated Plasma Protein-A - Analysisen_US
dc.subject.meshPrenatal Diagnosisen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshUltrasonography, Prenatalen_US
dc.titleThe influence of fetal sex in screening for trisomy 21 by fetal nuchal translucency, maternal serum free β-hCG and PAPP-A at 10-14 weeks of gestationen_US
dc.typeArticleen_US
dc.identifier.emailOng, CYT:cytong@hkucc.hku.hken_US
dc.identifier.authorityOng, CYT=rp00482en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/1097-0223(200008)20:8<673::AID-PD880>3.0.CO;2-5en_US
dc.identifier.pmid10951481-
dc.identifier.scopuseid_2-s2.0-0033880564en_US
dc.identifier.hkuros79013-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033880564&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume20en_US
dc.identifier.issue8en_US
dc.identifier.spage673en_US
dc.identifier.epage675en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSpencer, K=7202053140en_US
dc.identifier.scopusauthoridOng, CYT=7401968192en_US
dc.identifier.scopusauthoridLiao, AWJ=7006509060en_US
dc.identifier.scopusauthoridPapademetriou, D=23103835500en_US
dc.identifier.scopusauthoridNicolaides, KH=7203078780en_US

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