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Article: Randomized comparison of vaginal (200 μg every 3 h) and oral (400 μg every 3 h) misoprostol when combined with mifepristone in termination of second trimester pregnancy

TitleRandomized comparison of vaginal (200 μg every 3 h) and oral (400 μg every 3 h) misoprostol when combined with mifepristone in termination of second trimester pregnancy
Authors
Issue Date2000
PublisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/
Citation
Human Reproduction, 2000, v. 15 n. 10, p. 2205-2208 How to Cite?
AbstractIt is known that when misoprostol is given at 200 μg every 3 h after mifepristone pretreatment, the vaginal route is more effective than the oral route. However, women prefer the oral route. This randomized study was to test our hypothesis that oral misoprostol 400 μg is as effective as vaginal misoprostol 200 μg when given every 3 h in termination of second trimester pregnancy after priming with mifepristone. A total of 142 patients was randomly assigned to group 1 (200 mg mifepristone + 400 μg oral misoprostol every 3 h up to five doses) or group 2 (200 mg mifepristone + 200 μg vaginal misoprostol every 3 h up to five doses). The incidence of side-effects and the preference study were assessed through a standardized questionnaire during and after the abortion. For the oral group, both the incidence of diarrhoea (40.0 versus 23.2%, P = 0.03) and the amount of drug used (1734 compared with 812 μg, P < 0.0001) were significantly higher than that of the vaginal group but the incidence of fever appeared to be lower (not significant). There was no significant difference in complete abortion rate: 81.4% in the oral group and 75.4% in the vaginal group. The median induction-abortion interval was similar in the two groups (10.4 versus 10.0 h). The percentage of women who aborted in 24 h was also similar: 57/70 (81.4%) in the oral group and 58/69 (87.0%) in the vaginal group. Overall, 82.0% of women preferred the oral route. Oral misoprostol (400 μg) given every 3 h up to five doses, when combined with mifepristone, was as effective as the vaginal (200 μg) route in second trimester termination of pregnancy. This regimen could also be offered to those women who found repeated vaginal administration unacceptable.
Persistent Identifierhttp://hdl.handle.net/10722/173237
ISSN
2015 Impact Factor: 4.621
2015 SCImago Journal Rankings: 2.271
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNgai, SWen_US
dc.contributor.authorTang, OSen_US
dc.contributor.authorHo, PCen_US
dc.date.accessioned2012-10-30T06:28:42Z-
dc.date.available2012-10-30T06:28:42Z-
dc.date.issued2000en_US
dc.identifier.citationHuman Reproduction, 2000, v. 15 n. 10, p. 2205-2208en_US
dc.identifier.issn0268-1161en_US
dc.identifier.urihttp://hdl.handle.net/10722/173237-
dc.description.abstractIt is known that when misoprostol is given at 200 μg every 3 h after mifepristone pretreatment, the vaginal route is more effective than the oral route. However, women prefer the oral route. This randomized study was to test our hypothesis that oral misoprostol 400 μg is as effective as vaginal misoprostol 200 μg when given every 3 h in termination of second trimester pregnancy after priming with mifepristone. A total of 142 patients was randomly assigned to group 1 (200 mg mifepristone + 400 μg oral misoprostol every 3 h up to five doses) or group 2 (200 mg mifepristone + 200 μg vaginal misoprostol every 3 h up to five doses). The incidence of side-effects and the preference study were assessed through a standardized questionnaire during and after the abortion. For the oral group, both the incidence of diarrhoea (40.0 versus 23.2%, P = 0.03) and the amount of drug used (1734 compared with 812 μg, P < 0.0001) were significantly higher than that of the vaginal group but the incidence of fever appeared to be lower (not significant). There was no significant difference in complete abortion rate: 81.4% in the oral group and 75.4% in the vaginal group. The median induction-abortion interval was similar in the two groups (10.4 versus 10.0 h). The percentage of women who aborted in 24 h was also similar: 57/70 (81.4%) in the oral group and 58/69 (87.0%) in the vaginal group. Overall, 82.0% of women preferred the oral route. Oral misoprostol (400 μg) given every 3 h up to five doses, when combined with mifepristone, was as effective as the vaginal (200 μg) route in second trimester termination of pregnancy. This regimen could also be offered to those women who found repeated vaginal administration unacceptable.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/en_US
dc.relation.ispartofHuman Reproductionen_US
dc.rightsHuman Reproduction. Copyright © Oxford University Press.-
dc.subject.meshAbortifacient Agents, Nonsteroidal - Administration & Dosage - Adverse Effectsen_US
dc.subject.meshAbortifacient Agents, Steroidal - Pharmacologyen_US
dc.subject.meshAbortion, Induced - Methodsen_US
dc.subject.meshAdministration, Intravaginalen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshDiarrhea - Chemically Induceden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMifepristone - Pharmacologyen_US
dc.subject.meshMisoprostol - Administration & Dosage - Adverse Effectsen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Trimester, Seconden_US
dc.titleRandomized comparison of vaginal (200 μg every 3 h) and oral (400 μg every 3 h) misoprostol when combined with mifepristone in termination of second trimester pregnancyen_US
dc.typeArticleen_US
dc.identifier.emailHo, PC:pcho@hku.hken_US
dc.identifier.authorityHo, PC=rp00325en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/humrep/15.10.2205-
dc.identifier.pmid11006200-
dc.identifier.scopuseid_2-s2.0-0033772390en_US
dc.identifier.hkuros56149-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033772390&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume15en_US
dc.identifier.issue10en_US
dc.identifier.spage2205en_US
dc.identifier.epage2208en_US
dc.identifier.isiWOS:000089721400028-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridNgai, SW=7006074214en_US
dc.identifier.scopusauthoridTang, OS=7006723402en_US
dc.identifier.scopusauthoridHo, PC=7402211440en_US

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