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Article: Failure of magnesium sulfate infusion to inhibit uterine activity in pregnant sheep

TitleFailure of magnesium sulfate infusion to inhibit uterine activity in pregnant sheep
Authors
Issue Date1997
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajog
Citation
American Journal Of Obstetrics And Gynecology, 1997, v. 177 n. 1, p. 185-189 How to Cite?
AbstractOBJECTIVES: Our purpose was to determine the effect of magnesium sulfate infusion on nonlabor uterine contractures and corticotropin-induced preterm uterine contractions in pregnant sheep. STUDY DESIGN: Fetal and maternal vascular catheters and uterine electromyographic electrodes were surgically placed in 15 pregnant sheep between 118 and 125 days' gestation. After 3 to 5 days of recovery, magnesium sulfate was infused into 7 ewes with a 0.11 gm/kg bolus over 20 minutes, followed by 0.08 gm/kg/hr. In 8 animals labor was induced with use of an intrafetal corticotropin infusion, after which 4 ewes received magnesium sulfate and 4 received saline solution. Continuous recordings of uterine electromyographic activity, amniotic pressure, fetal heart rate, blood pressure, and tracheal pressure were made. Maternal and fetal magnesium, calcium, albumin concentrations, and blood gases were determined before and during the infusion. RESULTS: Maternal magnesium concentrations increased from an average of 0.94 ± 0.03 mmol/L to 2.73 ± 0.1 mmol/L at the end of the bolus, remaining elevated (2.44 ± 0.17 mmol/L) for 8 hours. Fetal magnesium concentrations (0.89 ± 0.03 mmol/L before the bolus) did not change with the maternal infusion. In ewes not in labor, uterine contractures occurred 3.7 ± 0.7 times per 2 hours before and did not change significantly with the infusion of magnesium sulfate. During corticotropin-induced preterm labor uterine contractions were present 13 ± 3.2 times per hour before infusions and were unchanged by infusion of magnesium sulfate to the ewes. CONCLUSIONS: Magnesium sulfate infusion in pregnant sheep has no effect on either nonlabor uterine contractures or on corticotropin-induced preterm uterine contractions.
Persistent Identifierhttp://hdl.handle.net/10722/173227
ISSN
2015 Impact Factor: 4.681
2015 SCImago Journal Rankings: 2.255
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAkoury, HAen_US
dc.contributor.authorWhite, SEen_US
dc.contributor.authorHoman, JHen_US
dc.contributor.authorCheung, VYTen_US
dc.contributor.authorRichardson, BSen_US
dc.contributor.authorBocking, ADen_US
dc.date.accessioned2012-10-30T06:28:38Z-
dc.date.available2012-10-30T06:28:38Z-
dc.date.issued1997en_US
dc.identifier.citationAmerican Journal Of Obstetrics And Gynecology, 1997, v. 177 n. 1, p. 185-189en_US
dc.identifier.issn0002-9378en_US
dc.identifier.urihttp://hdl.handle.net/10722/173227-
dc.description.abstractOBJECTIVES: Our purpose was to determine the effect of magnesium sulfate infusion on nonlabor uterine contractures and corticotropin-induced preterm uterine contractions in pregnant sheep. STUDY DESIGN: Fetal and maternal vascular catheters and uterine electromyographic electrodes were surgically placed in 15 pregnant sheep between 118 and 125 days' gestation. After 3 to 5 days of recovery, magnesium sulfate was infused into 7 ewes with a 0.11 gm/kg bolus over 20 minutes, followed by 0.08 gm/kg/hr. In 8 animals labor was induced with use of an intrafetal corticotropin infusion, after which 4 ewes received magnesium sulfate and 4 received saline solution. Continuous recordings of uterine electromyographic activity, amniotic pressure, fetal heart rate, blood pressure, and tracheal pressure were made. Maternal and fetal magnesium, calcium, albumin concentrations, and blood gases were determined before and during the infusion. RESULTS: Maternal magnesium concentrations increased from an average of 0.94 ± 0.03 mmol/L to 2.73 ± 0.1 mmol/L at the end of the bolus, remaining elevated (2.44 ± 0.17 mmol/L) for 8 hours. Fetal magnesium concentrations (0.89 ± 0.03 mmol/L before the bolus) did not change with the maternal infusion. In ewes not in labor, uterine contractures occurred 3.7 ± 0.7 times per 2 hours before and did not change significantly with the infusion of magnesium sulfate. During corticotropin-induced preterm labor uterine contractions were present 13 ± 3.2 times per hour before infusions and were unchanged by infusion of magnesium sulfate to the ewes. CONCLUSIONS: Magnesium sulfate infusion in pregnant sheep has no effect on either nonlabor uterine contractures or on corticotropin-induced preterm uterine contractions.en_US
dc.languageengen_US
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajogen_US
dc.relation.ispartofAmerican Journal of Obstetrics and Gynecologyen_US
dc.subject.meshAdrenocorticotropic Hormone - Adverse Effectsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Gas Analysisen_US
dc.subject.meshBlood Pressure - Drug Effects - Physiologyen_US
dc.subject.meshCalcium - Blooden_US
dc.subject.meshElectromyographyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetus - Drug Effects - Physiologyen_US
dc.subject.meshHeart Rate, Fetal - Drug Effects - Physiologyen_US
dc.subject.meshHemoglobins - Analysisen_US
dc.subject.meshInfusions, Intravenousen_US
dc.subject.meshMagnesium - Blooden_US
dc.subject.meshMagnesium Sulfate - Administration & Dosage - Pharmacologyen_US
dc.subject.meshNeurotransmitter Agents - Adverse Effectsen_US
dc.subject.meshObstetric Labor, Premature - Chemically Induceden_US
dc.subject.meshOxygen - Blooden_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy, Animal - Blood - Physiologyen_US
dc.subject.meshRespiration - Drug Effects - Physiologyen_US
dc.subject.meshSerum Albumin - Analysisen_US
dc.subject.meshSheepen_US
dc.subject.meshTocolytic Agents - Administration & Dosage - Pharmacologyen_US
dc.subject.meshUterine Contraction - Drug Effects - Physiologyen_US
dc.subject.meshUterus - Drug Effects - Physiologyen_US
dc.titleFailure of magnesium sulfate infusion to inhibit uterine activity in pregnant sheepen_US
dc.typeArticleen_US
dc.identifier.emailCheung, VYT:vytc@hku.hken_US
dc.identifier.authorityCheung, VYT=rp01323en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0002-9378(97)70460-5en_US
dc.identifier.pmid9240605-
dc.identifier.scopuseid_2-s2.0-0030876789en_US
dc.identifier.volume177en_US
dc.identifier.issue1en_US
dc.identifier.spage185en_US
dc.identifier.epage189en_US
dc.identifier.isiWOS:A1997XM17200032-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridAkoury, HA=6603206681en_US
dc.identifier.scopusauthoridWhite, SE=7404079422en_US
dc.identifier.scopusauthoridHoman, JH=7005737831en_US
dc.identifier.scopusauthoridCheung, VYT=7005439023en_US
dc.identifier.scopusauthoridRichardson, BS=7202396066en_US
dc.identifier.scopusauthoridBocking, AD=35517041400en_US

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