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Article: Misoprostol is as effective as gemeprost in termination of second trimester pregnancy when combined with mifepristone: A randomised comparative trial

TitleMisoprostol is as effective as gemeprost in termination of second trimester pregnancy when combined with mifepristone: A randomised comparative trial
Authors
Issue Date1996
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/contraception
Citation
Contraception, 1996, v. 53 n. 5, p. 281-283 How to Cite?
AbstractA prospective randomized study was conducted to compare the efficacy of misoprostol with gemeprost when combined with mifepristone for termination of second trimester pregnancy. Patients requesting termination of second trimester pregnancy were randomized into two groups. In both groups of patients, 200 mg of mifepristone was given 36 to 48 hours before the administration of prostaglandins. In Group 1, the women were given 400 μg of oral misoprostol every 3 hours up to 5 doses. In Group 2, patients were given 1 mg of vaginal gemeprost every 6 hours up to 4 doses. The main outcomes measured were the induction-abortion intervals (the interval between the first dose of prostaglandin and abortion) and the incidence of side effects. Altogether, 50 subjects were recruited with 25 women in each group. The mean age and parity of the women and the mean gestational age of the two groups of women were comparable. There was no significant difference in the median induction-abortion intervals (8.7 hours in Group 1 and 10.8 hours in Group 2) or the incidence of side effects between the two groups of patients. We conclude that misoprostol is as effective as gemeprost in termination of second trimester pregnancy when combined with mifepristone. | Findings are presented from a prospective randomized study conducted to compare the efficacy of misoprostol with gemeprost when combined with mifepristone to terminate second trimester pregnancy. 50 patients requesting the induced abortion of second trimester pregnancy were randomized into two groups of 25 women each. The mean age, parity, and mean gestational age of the two groups of women were comparable. 200 mg of mifepristone was administered to both groups of women 36-48 hours before the administration of prostaglandins. Women in group 1 were given 400 mcg of oral misoprostol every 3 hours up to five doses, while patients in group 2 were given 1 mg of vaginal gemeprost every 6 hours up to four doses. There was no significant difference in the median induction-abortion intervals or the incidence of side effects between the two groups of patients. The authors therefore conclude that misoprostol is as effective as gemeprost in terminating second trimester pregnancy when combined with mifepristone.
Persistent Identifierhttp://hdl.handle.net/10722/173221
ISSN
2015 Impact Factor: 2.788
2015 SCImago Journal Rankings: 1.557
References

 

DC FieldValueLanguage
dc.contributor.authorHo, PCen_US
dc.contributor.authorChan, YFen_US
dc.contributor.authorLau, Wen_US
dc.date.accessioned2012-10-30T06:28:36Z-
dc.date.available2012-10-30T06:28:36Z-
dc.date.issued1996en_US
dc.identifier.citationContraception, 1996, v. 53 n. 5, p. 281-283en_US
dc.identifier.issn0010-7824en_US
dc.identifier.urihttp://hdl.handle.net/10722/173221-
dc.description.abstractA prospective randomized study was conducted to compare the efficacy of misoprostol with gemeprost when combined with mifepristone for termination of second trimester pregnancy. Patients requesting termination of second trimester pregnancy were randomized into two groups. In both groups of patients, 200 mg of mifepristone was given 36 to 48 hours before the administration of prostaglandins. In Group 1, the women were given 400 μg of oral misoprostol every 3 hours up to 5 doses. In Group 2, patients were given 1 mg of vaginal gemeprost every 6 hours up to 4 doses. The main outcomes measured were the induction-abortion intervals (the interval between the first dose of prostaglandin and abortion) and the incidence of side effects. Altogether, 50 subjects were recruited with 25 women in each group. The mean age and parity of the women and the mean gestational age of the two groups of women were comparable. There was no significant difference in the median induction-abortion intervals (8.7 hours in Group 1 and 10.8 hours in Group 2) or the incidence of side effects between the two groups of patients. We conclude that misoprostol is as effective as gemeprost in termination of second trimester pregnancy when combined with mifepristone. | Findings are presented from a prospective randomized study conducted to compare the efficacy of misoprostol with gemeprost when combined with mifepristone to terminate second trimester pregnancy. 50 patients requesting the induced abortion of second trimester pregnancy were randomized into two groups of 25 women each. The mean age, parity, and mean gestational age of the two groups of women were comparable. 200 mg of mifepristone was administered to both groups of women 36-48 hours before the administration of prostaglandins. Women in group 1 were given 400 mcg of oral misoprostol every 3 hours up to five doses, while patients in group 2 were given 1 mg of vaginal gemeprost every 6 hours up to four doses. There was no significant difference in the median induction-abortion intervals or the incidence of side effects between the two groups of patients. The authors therefore conclude that misoprostol is as effective as gemeprost in terminating second trimester pregnancy when combined with mifepristone.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/contraceptionen_US
dc.relation.ispartofContraceptionen_US
dc.subject.meshAbortifacient Agents - Adverse Effectsen_US
dc.subject.meshAbortion, Induceden_US
dc.subject.meshAdulten_US
dc.subject.meshAlprostadil - Adverse Effects - Analogs & Derivativesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMifepristone - Administration & Dosage - Adverse Effectsen_US
dc.subject.meshMisoprostol - Administration & Dosage - Adverse Effectsen_US
dc.subject.meshPregnancyen_US
dc.titleMisoprostol is as effective as gemeprost in termination of second trimester pregnancy when combined with mifepristone: A randomised comparative trialen_US
dc.typeArticleen_US
dc.identifier.emailHo, PC:pcho@hku.hken_US
dc.identifier.authorityHo, PC=rp00325en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0010-7824(96)00061-3en_US
dc.identifier.pmid8724617-
dc.identifier.scopuseid_2-s2.0-0029923276en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029923276&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume53en_US
dc.identifier.issue5en_US
dc.identifier.spage281en_US
dc.identifier.epage283en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHo, PC=7402211440en_US
dc.identifier.scopusauthoridChan, YF=7403676061en_US
dc.identifier.scopusauthoridLau, W=36847553600en_US

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