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Article: A prospective randomized comparison of levonorgestrel with the Yuzpe regimen in post-coital contraception

TitleA prospective randomized comparison of levonorgestrel with the Yuzpe regimen in post-coital contraception
Authors
Issue Date1993
PublisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/
Citation
Human Reproduction, 1993, v. 8 n. 3, p. 389-392 How to Cite?
AbstractA prospective randomized study was conducted at the Family Planning Association of Hong Kong to compare the efficacy of the Yuzpe regimen and levonorgestrel (0.75 mg for two doses 12 h apart) in post-coital contraception. A total of 424 subjects were recruited into the Yuzpe group and 410 subjects into the levonorgestrel group; 77 subjects in the Yuzpe group and 79 subjects in the levonorgestrel group had further acts of intercourse during the treatment cycle. Fifteen pregnancies (3.5%) occurred in the Yuzpe group and 12 pregnancies (2.9%) in the levonorgestrel group. After excluding the patients who had further acts of intercourse, the failure rates in the Yuzpe group and the levonorgestrel group were 2.6 and 2.4% respectively. The incidence of nausea, vomiting and fatigue in the Yuzpe group was significantly higher than those in the levonorgestrel group. We conclude that levonorgestrel is an effective drug for post-coital contraception with a lower incidence of side-effects than the Yuzpe regimen.
Persistent Identifierhttp://hdl.handle.net/10722/173197
ISSN
2015 Impact Factor: 4.621
2015 SCImago Journal Rankings: 2.271
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, PCen_US
dc.contributor.authorKwan, MSWen_US
dc.date.accessioned2012-10-30T06:28:27Z-
dc.date.available2012-10-30T06:28:27Z-
dc.date.issued1993en_US
dc.identifier.citationHuman Reproduction, 1993, v. 8 n. 3, p. 389-392en_US
dc.identifier.issn0268-1161en_US
dc.identifier.urihttp://hdl.handle.net/10722/173197-
dc.description.abstractA prospective randomized study was conducted at the Family Planning Association of Hong Kong to compare the efficacy of the Yuzpe regimen and levonorgestrel (0.75 mg for two doses 12 h apart) in post-coital contraception. A total of 424 subjects were recruited into the Yuzpe group and 410 subjects into the levonorgestrel group; 77 subjects in the Yuzpe group and 79 subjects in the levonorgestrel group had further acts of intercourse during the treatment cycle. Fifteen pregnancies (3.5%) occurred in the Yuzpe group and 12 pregnancies (2.9%) in the levonorgestrel group. After excluding the patients who had further acts of intercourse, the failure rates in the Yuzpe group and the levonorgestrel group were 2.6 and 2.4% respectively. The incidence of nausea, vomiting and fatigue in the Yuzpe group was significantly higher than those in the levonorgestrel group. We conclude that levonorgestrel is an effective drug for post-coital contraception with a lower incidence of side-effects than the Yuzpe regimen.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/en_US
dc.relation.ispartofHuman Reproductionen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshContraceptives, Postcoital - Therapeutic Useen_US
dc.subject.meshDrug Combinationsen_US
dc.subject.meshEthinyl Estradiol - Administration & Dosage - Adverse Effects - Therapeutic Useen_US
dc.subject.meshFemaleen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshLevonorgestrel - Adverse Effects - Therapeutic Useen_US
dc.subject.meshNorgestrel - Administration & Dosage - Adverse Effects - Therapeutic Useen_US
dc.subject.meshPregnancyen_US
dc.subject.meshProspective Studiesen_US
dc.titleA prospective randomized comparison of levonorgestrel with the Yuzpe regimen in post-coital contraceptionen_US
dc.typeArticleen_US
dc.identifier.emailHo, PC:pcho@hku.hken_US
dc.identifier.authorityHo, PC=rp00325en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8473453-
dc.identifier.scopuseid_2-s2.0-0027513493en_US
dc.identifier.volume8en_US
dc.identifier.issue3en_US
dc.identifier.spage389en_US
dc.identifier.epage392en_US
dc.identifier.isiWOS:A1993KV69400010-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridHo, PC=7402211440en_US
dc.identifier.scopusauthoridKwan, MSW=36860235800en_US

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