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Article: Effects of androgens on fertilizing capacity of human spermatozoa

TitleEffects of androgens on fertilizing capacity of human spermatozoa
Authors
Issue Date1983
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/contraception
Citation
Contraception, 1983, v. 28 n. 5, p. 481-488 How to Cite?
AbstractThe potential functions of testosterone and 5 α -dihydrotestosterone, the androgens normally present in human seminal plasma, on human spermatozoal physiology were evaluated by studying the effects of these two steroid hormones on the in vitro fertilizing capacity of human spermatozoa. Spermatozoa collected from presumably fertile men were washed in BWW medium and incubated with different concentrations (0, 100, 250, 500, 1000 pg/ml) of testosterone or 5 α -dihydrotestosterone for 5 hr before insemination of the zona-free hamster ova. Penetration of the zona-free hamster ova was scored 6 hr later and the results were analyzed statistically. Both testosterone and 5 α -dihydrotestosterone, at the concentrations tested, significantly decreased in the in vitro penetration of the denuded hamster ova in comparison to the controls (p < 0.05). A dose-dependent response was also observed for the 5 α -dihydrotestosterone tested. These findings indicate that exogenous testosterone and 5 α -dihydrotestosterone can inhibit the fertilizing capacity of human spermatozoa in vitro, and suggest that the androgens normally present in human seminal plasma may serve, in part, to prevent premature spermatozoal capacitation before the spermatozoa reach the site of fertilization in vivo.
Persistent Identifierhttp://hdl.handle.net/10722/173072
ISSN
2015 Impact Factor: 2.788
2015 SCImago Journal Rankings: 1.557
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, SYWen_HK
dc.contributor.authorTang, LCHen_HK
dc.contributor.authorTang, GWKen_HK
dc.contributor.authorChan, PHen_HK
dc.date.accessioned2012-10-30T06:27:49Z-
dc.date.available2012-10-30T06:27:49Z-
dc.date.issued1983en_HK
dc.identifier.citationContraception, 1983, v. 28 n. 5, p. 481-488en_HK
dc.identifier.issn0010-7824en_HK
dc.identifier.urihttp://hdl.handle.net/10722/173072-
dc.description.abstractThe potential functions of testosterone and 5 α -dihydrotestosterone, the androgens normally present in human seminal plasma, on human spermatozoal physiology were evaluated by studying the effects of these two steroid hormones on the in vitro fertilizing capacity of human spermatozoa. Spermatozoa collected from presumably fertile men were washed in BWW medium and incubated with different concentrations (0, 100, 250, 500, 1000 pg/ml) of testosterone or 5 α -dihydrotestosterone for 5 hr before insemination of the zona-free hamster ova. Penetration of the zona-free hamster ova was scored 6 hr later and the results were analyzed statistically. Both testosterone and 5 α -dihydrotestosterone, at the concentrations tested, significantly decreased in the in vitro penetration of the denuded hamster ova in comparison to the controls (p < 0.05). A dose-dependent response was also observed for the 5 α -dihydrotestosterone tested. These findings indicate that exogenous testosterone and 5 α -dihydrotestosterone can inhibit the fertilizing capacity of human spermatozoa in vitro, and suggest that the androgens normally present in human seminal plasma may serve, in part, to prevent premature spermatozoal capacitation before the spermatozoa reach the site of fertilization in vivo.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/contraceptionen_HK
dc.relation.ispartofContraceptionen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshDihydrotestosterone - Pharmacologyen_US
dc.subject.meshFertilization In Vitro - Drug Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshSperm Motility - Drug Effectsen_US
dc.subject.meshSpermatozoa - Drug Effectsen_US
dc.subject.meshTestosterone - Pharmacologyen_US
dc.subject.meshTime Factorsen_US
dc.titleEffects of androgens on fertilizing capacity of human spermatozoaen_HK
dc.typeArticleen_HK
dc.identifier.emailTang, LCH: lchtang@hku.hken_HK
dc.identifier.emailTang, GWK: gwktang@hkucc.hku.hken_HK
dc.identifier.authorityTang, LCH=rp01756en_HK
dc.identifier.authorityTang, GWK=rp00328en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0010-7824(83)90079-3-
dc.identifier.pmid6673903-
dc.identifier.scopuseid_2-s2.0-0021040807en_HK
dc.identifier.volume28en_HK
dc.identifier.issue5en_HK
dc.identifier.spage481en_HK
dc.identifier.epage488en_HK
dc.identifier.isiWOS:A1983SF30200008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, SYW=7404255960en_HK
dc.identifier.scopusauthoridTang, LCH=7402081111en_HK
dc.identifier.scopusauthoridTang, GWK=7401633864en_HK
dc.identifier.scopusauthoridChan, PH=7403497875en_HK

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