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- Publisher Website: 10.1016/0165-0378(80)90004-2
- Scopus: eid_2-s2.0-0018867963
- PMID: 6251216
- WOS: WOS:A1980JK57600004
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Article: Immunological parameters in gestational trophoblastic neoplasia
Title | Immunological parameters in gestational trophoblastic neoplasia |
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Authors | |
Issue Date | 1980 |
Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jri |
Citation | Journal Of Reproductive Immunology, 1980, v. 1 n. 5-6, p. 307-319 How to Cite? |
Abstract | Immunological functions were studied in 22 patients with hydatidiform mole and 29 patients with malignant trophoblastic disease before and after treatment; normal pregnant and post-pregnant women served as controls. The only significant abnormality in hydatidiform mole was a low granulocyte chemotaxis before evacuation. In malignant trophoblastic disease the total lymphocyte counts, T-cell counts, B-cell counts, lymphocyte responses to mitogens and serum IgA levels were significantly lower than in normal women 6 wk after pregnancy. In those who responded to chemotherapy, these indices rose to the levels of post-pregnancy controls. An 'immune profile score' based on these indices was found to be a useful prognostic index. All patients with hydatidiform mole who had a score of 7 or less developed malignant trophoblastic disease, while the two patients with malignant trophoblastic disease who died had the lowest scores of the series. |
Persistent Identifier | http://hdl.handle.net/10722/173057 |
ISSN | 2023 Impact Factor: 2.9 2023 SCImago Journal Rankings: 0.915 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ho, PC | en_US |
dc.contributor.author | Mak, LW | en_US |
dc.contributor.author | Lawton, JWM | en_US |
dc.contributor.author | Ma, HK | en_US |
dc.date.accessioned | 2012-10-30T06:27:45Z | - |
dc.date.available | 2012-10-30T06:27:45Z | - |
dc.date.issued | 1980 | en_US |
dc.identifier.citation | Journal Of Reproductive Immunology, 1980, v. 1 n. 5-6, p. 307-319 | en_US |
dc.identifier.issn | 0165-0378 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/173057 | - |
dc.description.abstract | Immunological functions were studied in 22 patients with hydatidiform mole and 29 patients with malignant trophoblastic disease before and after treatment; normal pregnant and post-pregnant women served as controls. The only significant abnormality in hydatidiform mole was a low granulocyte chemotaxis before evacuation. In malignant trophoblastic disease the total lymphocyte counts, T-cell counts, B-cell counts, lymphocyte responses to mitogens and serum IgA levels were significantly lower than in normal women 6 wk after pregnancy. In those who responded to chemotherapy, these indices rose to the levels of post-pregnancy controls. An 'immune profile score' based on these indices was found to be a useful prognostic index. All patients with hydatidiform mole who had a score of 7 or less developed malignant trophoblastic disease, while the two patients with malignant trophoblastic disease who died had the lowest scores of the series. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jri | en_US |
dc.relation.ispartof | Journal of Reproductive Immunology | en_US |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | B-Lymphocytes | en_US |
dc.subject.mesh | Chemotaxis, Leukocyte | en_US |
dc.subject.mesh | Drug Therapy, Combination | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Hydatidiform Mole - Immunology | en_US |
dc.subject.mesh | Immunoglobulins | en_US |
dc.subject.mesh | Leukocyte Count | en_US |
dc.subject.mesh | Methotrexate - Therapeutic Use | en_US |
dc.subject.mesh | Mitogens - Pharmacology | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Skin Tests | en_US |
dc.subject.mesh | T-Lymphocytes | en_US |
dc.subject.mesh | Trophoblastic Neoplasms - Drug Therapy - Immunology | en_US |
dc.subject.mesh | Uterine Neoplasms - Immunology | en_US |
dc.title | Immunological parameters in gestational trophoblastic neoplasia | en_US |
dc.type | Article | en_US |
dc.identifier.email | Ho, PC:pcho@hku.hk | en_US |
dc.identifier.authority | Ho, PC=rp00325 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0165-0378(80)90004-2 | - |
dc.identifier.pmid | 6251216 | - |
dc.identifier.scopus | eid_2-s2.0-0018867963 | en_US |
dc.identifier.volume | 1 | en_US |
dc.identifier.issue | 5-6 | en_US |
dc.identifier.spage | 307 | en_US |
dc.identifier.epage | 319 | en_US |
dc.identifier.isi | WOS:A1980JK57600004 | - |
dc.publisher.place | Ireland | en_US |
dc.identifier.scopusauthorid | Ho, PC=7402211440 | en_US |
dc.identifier.scopusauthorid | Mak, LW=7004431376 | en_US |
dc.identifier.scopusauthorid | Lawton, JWM=7102180792 | en_US |
dc.identifier.scopusauthorid | Ma, HK=7403095603 | en_US |
dc.identifier.issnl | 0165-0378 | - |