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Article: Immunological parameters in gestational trophoblastic neoplasia

TitleImmunological parameters in gestational trophoblastic neoplasia
Authors
Issue Date1980
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jri
Citation
Journal Of Reproductive Immunology, 1980, v. 1 n. 5-6, p. 307-319 How to Cite?
AbstractImmunological functions were studied in 22 patients with hydatidiform mole and 29 patients with malignant trophoblastic disease before and after treatment; normal pregnant and post-pregnant women served as controls. The only significant abnormality in hydatidiform mole was a low granulocyte chemotaxis before evacuation. In malignant trophoblastic disease the total lymphocyte counts, T-cell counts, B-cell counts, lymphocyte responses to mitogens and serum IgA levels were significantly lower than in normal women 6 wk after pregnancy. In those who responded to chemotherapy, these indices rose to the levels of post-pregnancy controls. An 'immune profile score' based on these indices was found to be a useful prognostic index. All patients with hydatidiform mole who had a score of 7 or less developed malignant trophoblastic disease, while the two patients with malignant trophoblastic disease who died had the lowest scores of the series.
Persistent Identifierhttp://hdl.handle.net/10722/173057
ISSN
2015 Impact Factor: 3.202
2015 SCImago Journal Rankings: 1.233
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, PCen_US
dc.contributor.authorMak, LWen_US
dc.contributor.authorLawton, JWMen_US
dc.contributor.authorMa, HKen_US
dc.date.accessioned2012-10-30T06:27:45Z-
dc.date.available2012-10-30T06:27:45Z-
dc.date.issued1980en_US
dc.identifier.citationJournal Of Reproductive Immunology, 1980, v. 1 n. 5-6, p. 307-319en_US
dc.identifier.issn0165-0378en_US
dc.identifier.urihttp://hdl.handle.net/10722/173057-
dc.description.abstractImmunological functions were studied in 22 patients with hydatidiform mole and 29 patients with malignant trophoblastic disease before and after treatment; normal pregnant and post-pregnant women served as controls. The only significant abnormality in hydatidiform mole was a low granulocyte chemotaxis before evacuation. In malignant trophoblastic disease the total lymphocyte counts, T-cell counts, B-cell counts, lymphocyte responses to mitogens and serum IgA levels were significantly lower than in normal women 6 wk after pregnancy. In those who responded to chemotherapy, these indices rose to the levels of post-pregnancy controls. An 'immune profile score' based on these indices was found to be a useful prognostic index. All patients with hydatidiform mole who had a score of 7 or less developed malignant trophoblastic disease, while the two patients with malignant trophoblastic disease who died had the lowest scores of the series.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jrien_US
dc.relation.ispartofJournal of Reproductive Immunologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshB-Lymphocytesen_US
dc.subject.meshChemotaxis, Leukocyteen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHydatidiform Mole - Immunologyen_US
dc.subject.meshImmunoglobulinsen_US
dc.subject.meshLeukocyte Counten_US
dc.subject.meshMethotrexate - Therapeutic Useen_US
dc.subject.meshMitogens - Pharmacologyen_US
dc.subject.meshPregnancyen_US
dc.subject.meshSkin Testsen_US
dc.subject.meshT-Lymphocytesen_US
dc.subject.meshTrophoblastic Neoplasms - Drug Therapy - Immunologyen_US
dc.subject.meshUterine Neoplasms - Immunologyen_US
dc.titleImmunological parameters in gestational trophoblastic neoplasiaen_US
dc.typeArticleen_US
dc.identifier.emailHo, PC:pcho@hku.hken_US
dc.identifier.authorityHo, PC=rp00325en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0165-0378(80)90004-2-
dc.identifier.pmid6251216-
dc.identifier.scopuseid_2-s2.0-0018867963en_US
dc.identifier.volume1en_US
dc.identifier.issue5-6en_US
dc.identifier.spage307en_US
dc.identifier.epage319en_US
dc.identifier.isiWOS:A1980JK57600004-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridHo, PC=7402211440en_US
dc.identifier.scopusauthoridMak, LW=7004431376en_US
dc.identifier.scopusauthoridLawton, JWM=7102180792en_US
dc.identifier.scopusauthoridMa, HK=7403095603en_US

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