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Article: Hepatocellular carcinoma-resection or transplant?

TitleHepatocellular carcinoma-resection or transplant?
Authors
Issue Date2012
Citation
Nature Reviews Gastroenterology And Hepatology, 2012, v. 9 n. 12, p. 732-737 How to Cite?
AbstractResection and liver transplantation are considered effective treatments for early-stage hepatocellular carcinoma (HCC). As data from randomized trials are lacking, the choice of technique is controversial. Retrospective analyses suggest that for patients with suboptimal liver function, transplantation is the preferred treatment. For patients with preserved liver function and HCC within the Milan criteria, the overall survival rate is similar for both techniques; therefore resection is the preferred treatment. For tumours beyond the Milan criteria but within acceptable expanded criteria, transplantation has a more favourable outcome than resection. As liver grafts are in short supply, resection followed by transplantation once intrahepatic recurrence is detected would spare patients with favourable or very aggressive tumours from transplantation and enable patients with moderately aggressive tumours to undergo timely transplantation. Currently, resection and transplantation are considered complementary in the management of HCC. Expanding the transplantation and resection criteria of HCC needs to be investigated.
Persistent Identifierhttp://hdl.handle.net/10722/173045
ISSN
2015 Impact Factor: 14.435
2015 SCImago Journal Rankings: 3.909
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFan, STen_US
dc.date.accessioned2012-10-30T06:26:57Z-
dc.date.available2012-10-30T06:26:57Z-
dc.date.issued2012en_US
dc.identifier.citationNature Reviews Gastroenterology And Hepatology, 2012, v. 9 n. 12, p. 732-737en_US
dc.identifier.issn1759-5045en_US
dc.identifier.urihttp://hdl.handle.net/10722/173045-
dc.description.abstractResection and liver transplantation are considered effective treatments for early-stage hepatocellular carcinoma (HCC). As data from randomized trials are lacking, the choice of technique is controversial. Retrospective analyses suggest that for patients with suboptimal liver function, transplantation is the preferred treatment. For patients with preserved liver function and HCC within the Milan criteria, the overall survival rate is similar for both techniques; therefore resection is the preferred treatment. For tumours beyond the Milan criteria but within acceptable expanded criteria, transplantation has a more favourable outcome than resection. As liver grafts are in short supply, resection followed by transplantation once intrahepatic recurrence is detected would spare patients with favourable or very aggressive tumours from transplantation and enable patients with moderately aggressive tumours to undergo timely transplantation. Currently, resection and transplantation are considered complementary in the management of HCC. Expanding the transplantation and resection criteria of HCC needs to be investigated.en_US
dc.languageengen_US
dc.relation.ispartofNature Reviews Gastroenterology and Hepatologyen_US
dc.titleHepatocellular carcinoma-resection or transplant?en_US
dc.typeArticleen_US
dc.identifier.emailFan, ST: stfan@hku.hken_US
dc.identifier.authorityFan, ST=rp00355en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/nrgastro.2012.158en_US
dc.identifier.pmid22965432-
dc.identifier.scopuseid_2-s2.0-84870624025en_US
dc.identifier.hkuros213644-
dc.identifier.isiWOS:000311946100008-
dc.identifier.scopusauthoridFan, ST=7402678224en_US

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