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Article: Curcumin inhibits tongue carcinoma cells migration and invasion through downregulation of matrix metallopeptidase 10

TitleCurcumin inhibits tongue carcinoma cells migration and invasion through downregulation of matrix metallopeptidase 10
Authors
KeywordsCurcumin
Matrix Metallopepetidase 10
Migration
Squamous Cell Carcinoma
Tongue
Issue Date2012
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/07357907.asp
Citation
Cancer Investigation, 2012, v. 30 n. 7, p. 503-512 How to Cite?
AbstractSquamous cell carcinoma (SCC) of tongue is an aggressive head and neck cancer with high propensity of regional spreading and invasion. Tongue carcinoma cells treated with curcumin, the major curcuminoid of the turmeric, demonstrated reduction in adhesion, migration, and invasion ability. High-throughput microarray analysis indicated that curcumin treatment suppressed matrix metallopeptidase 10 (MMP10) expression. MMP10 is overexpressed in tongue carcinoma tissues in comparison with the normal epithelia. Curcumin treatment on tongue carcinoma cell lines suppressed MMP10 expression at both mRNA and protein levels. Our results suggested that curcumin is a promising inhibitor to tongue cancer cells migration and invasion. Copyright © 2012 Informa Healthcare USA, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/173035
ISSN
2015 Impact Factor: 2.231
2015 SCImago Journal Rankings: 0.991
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTsang, RKYen_US
dc.contributor.authorTang, WWYen_US
dc.contributor.authorGao, Wen_US
dc.contributor.authorHo, WKen_US
dc.contributor.authorChan, JYWen_US
dc.contributor.authorWei, WIen_US
dc.contributor.authorWong, TSen_US
dc.date.accessioned2012-10-30T06:26:46Z-
dc.date.available2012-10-30T06:26:46Z-
dc.date.issued2012en_US
dc.identifier.citationCancer Investigation, 2012, v. 30 n. 7, p. 503-512en_US
dc.identifier.issn0735-7907en_US
dc.identifier.urihttp://hdl.handle.net/10722/173035-
dc.description.abstractSquamous cell carcinoma (SCC) of tongue is an aggressive head and neck cancer with high propensity of regional spreading and invasion. Tongue carcinoma cells treated with curcumin, the major curcuminoid of the turmeric, demonstrated reduction in adhesion, migration, and invasion ability. High-throughput microarray analysis indicated that curcumin treatment suppressed matrix metallopeptidase 10 (MMP10) expression. MMP10 is overexpressed in tongue carcinoma tissues in comparison with the normal epithelia. Curcumin treatment on tongue carcinoma cell lines suppressed MMP10 expression at both mRNA and protein levels. Our results suggested that curcumin is a promising inhibitor to tongue cancer cells migration and invasion. Copyright © 2012 Informa Healthcare USA, Inc.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/07357907.aspen_US
dc.relation.ispartofCancer Investigationen_US
dc.subjectCurcuminen_US
dc.subjectMatrix Metallopepetidase 10en_US
dc.subjectMigrationen_US
dc.subjectSquamous Cell Carcinomaen_US
dc.subjectTongueen_US
dc.titleCurcumin inhibits tongue carcinoma cells migration and invasion through downregulation of matrix metallopeptidase 10en_US
dc.typeArticleen_US
dc.identifier.emailWong, TS: thiansze@graduate.hku.hken_US
dc.identifier.emailTsang, RKY: rkytsang@hku.hk-
dc.identifier.emailGao, W: weigao@graduate.hku.hk-
dc.identifier.emailHo, WK: wkho@hkucc.hku.hk-
dc.identifier.emailChan, JYW: jywchan1@hku.hk-
dc.identifier.emailWei, WI: hrmswwi@hku.hk-
dc.identifier.authorityWong, TS=rp00478en_US
dc.identifier.authorityTsang, RKY=rp01386-
dc.identifier.authorityWei, WI=rp00323-
dc.identifier.authorityChan, JYW=rp01314-
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.3109/07357907.2012.691192en_US
dc.identifier.pmid22624612-
dc.identifier.scopuseid_2-s2.0-84863974406en_US
dc.identifier.hkuros200588-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863974406&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume30en_US
dc.identifier.issue7en_US
dc.identifier.spage503en_US
dc.identifier.epage512en_US
dc.identifier.eissn1532-4192-
dc.identifier.isiWOS:000306421800002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTsang, RKY=55314801700en_US
dc.identifier.scopusauthoridTang, WWY=36469039200en_US
dc.identifier.scopusauthoridGao, W=55252457300en_US
dc.identifier.scopusauthoridHo, WK=7402968844en_US
dc.identifier.scopusauthoridChan, JYW=55270446700en_US
dc.identifier.scopusauthoridWei, WI=55251021200en_US
dc.identifier.scopusauthoridWong, TS=7403531328en_US

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