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Article: Regulators of mammalian Hippo pathway in cancer

TitleRegulators of mammalian Hippo pathway in cancer
Authors
KeywordsHippo Signaling
Lats1/2
Mst1/2
Regulators
Solid Cancer
Yap
Issue Date2012
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbaroco
Citation
Biochimica Et Biophysica Acta - Reviews On Cancer, 2012, v. 1826 n. 2, p. 357-364 How to Cite?
AbstractHippo pathway, originally discovered in Drosophila, is responsible for organ size control. The pathway is conserved in mammals and has a significant role in restraining cancer development. Regulating the Hippo pathway thus represents a potential therapeutic approach to treat cancer, which however requires deep understanding of the targeted pathway. Despite our limited knowledge on the pathway, there are increasing discoveries of new molecules that regulate and modulate the Hippo downstream signaling particularly in various solid malignancies, from extracellular stimuli or via pathway crosstalk. Herein, we discuss the roles of newly identified and key regulators that connect with core components (MST1/2, LATS1/2, SAV1, and MOB1) and downstream effector (YAP) in the Hippo pathway having an important role in cancer development and progression. Understanding of the mammalian Hippo pathway regulation may shed new insights to allow us selecting the right oncogenic targets and designing effective drugs for cancer treatments. © 2012 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/173029
ISSN
2015 Impact Factor: 7.841
2015 SCImago Journal Rankings: 3.852
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, AMen_US
dc.contributor.authorWong, KFen_US
dc.contributor.authorJiang, Xen_US
dc.contributor.authorQiao, Yen_US
dc.contributor.authorLuk, JMen_US
dc.date.accessioned2012-10-30T06:26:40Z-
dc.date.available2012-10-30T06:26:40Z-
dc.date.issued2012en_US
dc.identifier.citationBiochimica Et Biophysica Acta - Reviews On Cancer, 2012, v. 1826 n. 2, p. 357-364en_US
dc.identifier.issn0304-419Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/173029-
dc.description.abstractHippo pathway, originally discovered in Drosophila, is responsible for organ size control. The pathway is conserved in mammals and has a significant role in restraining cancer development. Regulating the Hippo pathway thus represents a potential therapeutic approach to treat cancer, which however requires deep understanding of the targeted pathway. Despite our limited knowledge on the pathway, there are increasing discoveries of new molecules that regulate and modulate the Hippo downstream signaling particularly in various solid malignancies, from extracellular stimuli or via pathway crosstalk. Herein, we discuss the roles of newly identified and key regulators that connect with core components (MST1/2, LATS1/2, SAV1, and MOB1) and downstream effector (YAP) in the Hippo pathway having an important role in cancer development and progression. Understanding of the mammalian Hippo pathway regulation may shed new insights to allow us selecting the right oncogenic targets and designing effective drugs for cancer treatments. © 2012 Elsevier B.V.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbarocoen_US
dc.relation.ispartofBiochimica et Biophysica Acta - Reviews on Canceren_US
dc.subjectHippo Signalingen_US
dc.subjectLats1/2en_US
dc.subjectMst1/2en_US
dc.subjectRegulatorsen_US
dc.subjectSolid Canceren_US
dc.subjectYapen_US
dc.titleRegulators of mammalian Hippo pathway in canceren_US
dc.typeArticleen_US
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_US
dc.identifier.authorityLuk, JM=rp00349en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.bbcan.2012.05.006en_US
dc.identifier.pmid22683405-
dc.identifier.scopuseid_2-s2.0-84862683338en_US
dc.identifier.volume1826en_US
dc.identifier.issue2en_US
dc.identifier.spage357en_US
dc.identifier.epage364en_US
dc.identifier.isiWOS:000310104900008-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLiu, AM=36134439500en_US
dc.identifier.scopusauthoridWong, KF=49362744900en_US
dc.identifier.scopusauthoridJiang, X=55258295200en_US
dc.identifier.scopusauthoridQiao, Y=55258212400en_US
dc.identifier.scopusauthoridLuk, JM=7006777791en_US
dc.identifier.citeulike10770148-

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