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Article: Rapid measurement of indocyanine green retention by pulse spectrophotometry: A validation study in 70 patients with Child-Pugh A cirrhosis before hepatectomy for hepatocellular carcinoma

TitleRapid measurement of indocyanine green retention by pulse spectrophotometry: A validation study in 70 patients with Child-Pugh A cirrhosis before hepatectomy for hepatocellular carcinoma
Authors
KeywordsChild-Pugh A
Hepatocellular Carcinoma
Indocyanine Green Clearance
Limon
Liver Cirrhosis
Pulse Spectrophotometry
Issue Date2012
PublisherThe First Affiliated Hospital, Zhejiang University School of Medicine. The Journal's web site is located at http://www.hbpdint.com/
Citation
Hepatobiliary And Pancreatic Diseases International, 2012, v. 11 n. 3, p. 267-271 How to Cite?
AbstractBACKGROUND: The indocyanine green (ICG) retention test is the most popular liver function test for selecting patients for major hepatectomy. Traditionally, it is done using spectrophotometry with serial blood sampling. The newly-developed pulse spectrophotometry is a faster alternative, but its accuracy on Child-Pugh A cirrhotic patients undergoing hepatectomy for hepatocellular carcinoma has not been well documented. This study aimed to assess the accuracy of the LiMON®, one of the pulse spectrophotometry systems, in measuring preoperative ICG retention in these patients and to devise an easy formula for conversion of the results so that they can be compared with classical literature records where ICG retention was measured by the traditional method. METHODS: We measured the liver function of 70 Child-Pugh A cirrhotic patients before hepatectomy for hepatocellular carcinoma from September 2008 to January 2009. ICG retention at 15 minutes measured by traditional spectrophotometry (ICGR15) was compared with ICG retention at 15 minutes measured by the LiMON (ICGR15(L)). RESULTS: The median ICGR15 was 14.7% (5.6%-32%) and the median ICGR15(L) was 10.4% (1.2%-28%). The mean difference between them was -4.3606. There was a strong correlation between ICGR15 and ICGR15(L) (correlation coefficient, 0.844; 95% confidence interval, 0.762-0.899). The following formula was devised: ICGR15=1.16×ICGR15(L)+2.73. CONCLUSIONS: The LiMON provides a fast and repeatable way to measure ICG retention at 15 minutes, but with constant underestimation of the real value. Therefore, when comparing results obtained by traditional spectrophotometry and the LiMON, adjustment of results from the latter is necessary, and this can be done with a simple mathematical calculation using the above formula. © 2012, Hepatobiliary Pancreat Dis Int.
Persistent Identifierhttp://hdl.handle.net/10722/173027
ISSN
2015 Impact Factor: 1.724
2015 SCImago Journal Rankings: 0.717
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, TTen_US
dc.contributor.authorChan, SCen_US
dc.contributor.authorChok, KSHen_US
dc.contributor.authorChan, ACYen_US
dc.contributor.authorYu, WCen_US
dc.contributor.authorPoon, RTPen_US
dc.contributor.authorLo, CMen_US
dc.contributor.authorFan, STen_US
dc.date.accessioned2012-10-30T06:26:39Z-
dc.date.available2012-10-30T06:26:39Z-
dc.date.issued2012en_US
dc.identifier.citationHepatobiliary And Pancreatic Diseases International, 2012, v. 11 n. 3, p. 267-271en_US
dc.identifier.issn1499-3872en_US
dc.identifier.urihttp://hdl.handle.net/10722/173027-
dc.description.abstractBACKGROUND: The indocyanine green (ICG) retention test is the most popular liver function test for selecting patients for major hepatectomy. Traditionally, it is done using spectrophotometry with serial blood sampling. The newly-developed pulse spectrophotometry is a faster alternative, but its accuracy on Child-Pugh A cirrhotic patients undergoing hepatectomy for hepatocellular carcinoma has not been well documented. This study aimed to assess the accuracy of the LiMON®, one of the pulse spectrophotometry systems, in measuring preoperative ICG retention in these patients and to devise an easy formula for conversion of the results so that they can be compared with classical literature records where ICG retention was measured by the traditional method. METHODS: We measured the liver function of 70 Child-Pugh A cirrhotic patients before hepatectomy for hepatocellular carcinoma from September 2008 to January 2009. ICG retention at 15 minutes measured by traditional spectrophotometry (ICGR15) was compared with ICG retention at 15 minutes measured by the LiMON (ICGR15(L)). RESULTS: The median ICGR15 was 14.7% (5.6%-32%) and the median ICGR15(L) was 10.4% (1.2%-28%). The mean difference between them was -4.3606. There was a strong correlation between ICGR15 and ICGR15(L) (correlation coefficient, 0.844; 95% confidence interval, 0.762-0.899). The following formula was devised: ICGR15=1.16×ICGR15(L)+2.73. CONCLUSIONS: The LiMON provides a fast and repeatable way to measure ICG retention at 15 minutes, but with constant underestimation of the real value. Therefore, when comparing results obtained by traditional spectrophotometry and the LiMON, adjustment of results from the latter is necessary, and this can be done with a simple mathematical calculation using the above formula. © 2012, Hepatobiliary Pancreat Dis Int.en_US
dc.languageengen_US
dc.publisherThe First Affiliated Hospital, Zhejiang University School of Medicine. The Journal's web site is located at http://www.hbpdint.com/en_US
dc.relation.ispartofHepatobiliary and Pancreatic Diseases Internationalen_US
dc.subjectChild-Pugh Aen_US
dc.subjectHepatocellular Carcinomaen_US
dc.subjectIndocyanine Green Clearanceen_US
dc.subjectLimonen_US
dc.subjectLiver Cirrhosisen_US
dc.subjectPulse Spectrophotometryen_US
dc.titleRapid measurement of indocyanine green retention by pulse spectrophotometry: A validation study in 70 patients with Child-Pugh A cirrhosis before hepatectomy for hepatocellular carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hken_US
dc.identifier.emailChan, ACY: acchan@hku.hken_US
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_US
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_US
dc.identifier.emailCheung, TT: cheung68@hku.hk-
dc.identifier.emailYu, WC: yuwc@hku.hk-
dc.identifier.emailFan, ST: stfan@hku.hk-
dc.identifier.authorityChan, SC=rp01568en_US
dc.identifier.authorityChan, ACY=rp00310en_US
dc.identifier.authorityPoon, RTP=rp00446en_US
dc.identifier.authorityLo, CM=rp00412en_US
dc.identifier.authorityFan, ST=rp00355-
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1016/S1499-3872(12)60159-3en_US
dc.identifier.pmid22672820-
dc.identifier.scopuseid_2-s2.0-84861978536en_US
dc.identifier.hkuros211060-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84861978536&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume11en_US
dc.identifier.issue3en_US
dc.identifier.spage267en_US
dc.identifier.epage271en_US
dc.identifier.isiWOS:000305109000006-
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridCheung, TT=7103334165en_US
dc.identifier.scopusauthoridChan, SC=7404255575en_US
dc.identifier.scopusauthoridChok, KSH=6508229426en_US
dc.identifier.scopusauthoridChan, ACY=15828849100en_US
dc.identifier.scopusauthoridYu, WC=55216510100en_US
dc.identifier.scopusauthoridPoon, RTP=7103097223en_US
dc.identifier.scopusauthoridLo, CM=7401771672en_US
dc.identifier.scopusauthoridFan, ST=55245914000en_US

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