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Article: Clinical significance of SOD2 and GSTP1 gene polymorphisms in Chinese patients with gastric cancer
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TitleClinical significance of SOD2 and GSTP1 gene polymorphisms in Chinese patients with gastric cancer
 
AuthorsXu, Z3
Zhu, H1
Luk, JM3 5
Wu, D3
Gu, D3
Gong, W2
Tan, Y4
Zhou, J3
Tang, J6
Zhang, Z3
Wang, M3
Chen, J3
 
KeywordsGlutathione S-Transferase Π
Reactive Oxygen Species
Single Nucleotide Polymorphism
Stomach Neoplasms
Superoxide Dismutase 2
 
Issue Date2012
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
 
CitationCancer, 2012, v. 118 n. 22, p. 5489-5496 [How to Cite?]
DOI: http://dx.doi.org/10.1002/cncr.27599
 
AbstractBACKGROUND:: Excessive reactive oxygen species (ROS) accumulation is a common phenomenon in carcinogenesis. However, the rationale behind ROS involvement in gastric cancer is unclear. In this study, the authors investigated the clinical significance of the single nucleotide polymorphisms (SNPs) of 2 ROS metabolic process-related genes: superoxide dismutase 2 (SOD2) and glutathione S-transferase π (GSTP1). METHODS:: In total of 929 patients with gastric cancer who had definitive clinicopathologic and follow-up data were collected. SOD2 reference SNP 4880 (rs4880) and GSTP1 rs1695 genotyping were examined in DNA samples extracted from paraffin-embedded tumor tissue. Association of the 2 SNPs with each clinicopathologic feature was analyzed using the Pearson chi-square test and the independent Student t test. Gastric cancer-specific overall survival was analyzed using Kaplan-Meier curves and log-rank tests. Multivariate Cox regression analyses of these SNPs also were performed. RESULTS:: The SOD2 rs4880 CT + CC genotypes were significantly associated with a high level of lymph node metastasis (P = .023), whereas the GSTP1 rs1695 GA + GG genotypes were significantly associated with larger tumor size (>5 cm long; P = .048). Kaplan-Meier and Cox regression data indicated that the SOD2 rs4880 CT + CC genotypes alone (hazard ratio, 1.299; 95% confidence interval, 1.053-1.603; P = .015) and the GSTP1 rs1695 GA + GG combined genotypes (hazard ratio, 1.496; 95% CI, 1.078-2.074; P = .016) were independent predictors for overall survival. CONCLUSIONS:: The current data, based on a large cohort (n = 929) of Chinese patients with gastric cancer, suggested that the presence of SOD2 rs4880 and GSTP1 rs1695 genotypes may contribute to cancer progression as well as tumor aggressiveness. The components of ROS metabolism pathways may be potential therapeutic targets for this aggressive malignancy. Cancer 2012. © 2012 American Cancer Society.
 
ISSN0008-543X
2012 Impact Factor: 5.201
2012 SCImago Journal Rankings: 2.407
 
DOIhttp://dx.doi.org/10.1002/cncr.27599
 
DC FieldValue
dc.contributor.authorXu, Z
 
dc.contributor.authorZhu, H
 
dc.contributor.authorLuk, JM
 
dc.contributor.authorWu, D
 
dc.contributor.authorGu, D
 
dc.contributor.authorGong, W
 
dc.contributor.authorTan, Y
 
dc.contributor.authorZhou, J
 
dc.contributor.authorTang, J
 
dc.contributor.authorZhang, Z
 
dc.contributor.authorWang, M
 
dc.contributor.authorChen, J
 
dc.date.accessioned2012-10-30T06:26:35Z
 
dc.date.available2012-10-30T06:26:35Z
 
dc.date.issued2012
 
dc.description.abstractBACKGROUND:: Excessive reactive oxygen species (ROS) accumulation is a common phenomenon in carcinogenesis. However, the rationale behind ROS involvement in gastric cancer is unclear. In this study, the authors investigated the clinical significance of the single nucleotide polymorphisms (SNPs) of 2 ROS metabolic process-related genes: superoxide dismutase 2 (SOD2) and glutathione S-transferase π (GSTP1). METHODS:: In total of 929 patients with gastric cancer who had definitive clinicopathologic and follow-up data were collected. SOD2 reference SNP 4880 (rs4880) and GSTP1 rs1695 genotyping were examined in DNA samples extracted from paraffin-embedded tumor tissue. Association of the 2 SNPs with each clinicopathologic feature was analyzed using the Pearson chi-square test and the independent Student t test. Gastric cancer-specific overall survival was analyzed using Kaplan-Meier curves and log-rank tests. Multivariate Cox regression analyses of these SNPs also were performed. RESULTS:: The SOD2 rs4880 CT + CC genotypes were significantly associated with a high level of lymph node metastasis (P = .023), whereas the GSTP1 rs1695 GA + GG genotypes were significantly associated with larger tumor size (>5 cm long; P = .048). Kaplan-Meier and Cox regression data indicated that the SOD2 rs4880 CT + CC genotypes alone (hazard ratio, 1.299; 95% confidence interval, 1.053-1.603; P = .015) and the GSTP1 rs1695 GA + GG combined genotypes (hazard ratio, 1.496; 95% CI, 1.078-2.074; P = .016) were independent predictors for overall survival. CONCLUSIONS:: The current data, based on a large cohort (n = 929) of Chinese patients with gastric cancer, suggested that the presence of SOD2 rs4880 and GSTP1 rs1695 genotypes may contribute to cancer progression as well as tumor aggressiveness. The components of ROS metabolism pathways may be potential therapeutic targets for this aggressive malignancy. Cancer 2012. © 2012 American Cancer Society.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationCancer, 2012, v. 118 n. 22, p. 5489-5496 [How to Cite?]
DOI: http://dx.doi.org/10.1002/cncr.27599
 
dc.identifier.doihttp://dx.doi.org/10.1002/cncr.27599
 
dc.identifier.issn0008-543X
2012 Impact Factor: 5.201
2012 SCImago Journal Rankings: 2.407
 
dc.identifier.pmid22517484
 
dc.identifier.scopuseid_2-s2.0-84868191177
 
dc.identifier.urihttp://hdl.handle.net/10722/173021
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
 
dc.publisher.placeUnited States
 
dc.relation.ispartofCancer
 
dc.subjectGlutathione S-Transferase Π
 
dc.subjectReactive Oxygen Species
 
dc.subjectSingle Nucleotide Polymorphism
 
dc.subjectStomach Neoplasms
 
dc.subjectSuperoxide Dismutase 2
 
dc.titleClinical significance of SOD2 and GSTP1 gene polymorphisms in Chinese patients with gastric cancer
 
dc.typeArticle
 
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<item><contributor.author>Xu, Z</contributor.author>
<contributor.author>Zhu, H</contributor.author>
<contributor.author>Luk, JM</contributor.author>
<contributor.author>Wu, D</contributor.author>
<contributor.author>Gu, D</contributor.author>
<contributor.author>Gong, W</contributor.author>
<contributor.author>Tan, Y</contributor.author>
<contributor.author>Zhou, J</contributor.author>
<contributor.author>Tang, J</contributor.author>
<contributor.author>Zhang, Z</contributor.author>
<contributor.author>Wang, M</contributor.author>
<contributor.author>Chen, J</contributor.author>
<date.accessioned>2012-10-30T06:26:35Z</date.accessioned>
<date.available>2012-10-30T06:26:35Z</date.available>
<date.issued>2012</date.issued>
<identifier.citation>Cancer, 2012, v. 118 n. 22, p. 5489-5496</identifier.citation>
<identifier.issn>0008-543X</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/173021</identifier.uri>
<description.abstract>BACKGROUND:: Excessive reactive oxygen species (ROS) accumulation is a common phenomenon in carcinogenesis. However, the rationale behind ROS involvement in gastric cancer is unclear. In this study, the authors investigated the clinical significance of the single nucleotide polymorphisms (SNPs) of 2 ROS metabolic process-related genes: superoxide dismutase 2 (SOD2) and glutathione S-transferase &#960; (GSTP1). METHODS:: In total of 929 patients with gastric cancer who had definitive clinicopathologic and follow-up data were collected. SOD2 reference SNP 4880 (rs4880) and GSTP1 rs1695 genotyping were examined in DNA samples extracted from paraffin-embedded tumor tissue. Association of the 2 SNPs with each clinicopathologic feature was analyzed using the Pearson chi-square test and the independent Student t test. Gastric cancer-specific overall survival was analyzed using Kaplan-Meier curves and log-rank tests. Multivariate Cox regression analyses of these SNPs also were performed. RESULTS:: The SOD2 rs4880 CT + CC genotypes were significantly associated with a high level of lymph node metastasis (P = .023), whereas the GSTP1 rs1695 GA + GG genotypes were significantly associated with larger tumor size (&gt;5 cm long; P = .048). Kaplan-Meier and Cox regression data indicated that the SOD2 rs4880 CT + CC genotypes alone (hazard ratio, 1.299; 95% confidence interval, 1.053-1.603; P = .015) and the GSTP1 rs1695 GA + GG combined genotypes (hazard ratio, 1.496; 95% CI, 1.078-2.074; P = .016) were independent predictors for overall survival. CONCLUSIONS:: The current data, based on a large cohort (n = 929) of Chinese patients with gastric cancer, suggested that the presence of SOD2 rs4880 and GSTP1 rs1695 genotypes may contribute to cancer progression as well as tumor aggressiveness. The components of ROS metabolism pathways may be potential therapeutic targets for this aggressive malignancy. Cancer 2012. &#169; 2012 American Cancer Society.</description.abstract>
<language>eng</language>
<publisher>John Wiley &amp; Sons, Inc. The Journal&apos;s web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741</publisher>
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<subject>Glutathione S-Transferase &#928;</subject>
<subject>Reactive Oxygen Species</subject>
<subject>Single Nucleotide Polymorphism</subject>
<subject>Stomach Neoplasms</subject>
<subject>Superoxide Dismutase 2</subject>
<title>Clinical significance of SOD2 and GSTP1 gene polymorphisms in Chinese patients with gastric cancer</title>
<type>Article</type>
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<identifier.doi>10.1002/cncr.27599</identifier.doi>
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Author Affiliations
  1. Nantong Cancer Hospital
  2. Yixing Cancer Hospital
  3. Nanjing Medical University
  4. Yixing People's Hospital
  5. Roche Research and Development Center (China) Ltd.
  6. null