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Article: Clinical significance of SOD2 and GSTP1 gene polymorphisms in Chinese patients with gastric cancer

TitleClinical significance of SOD2 and GSTP1 gene polymorphisms in Chinese patients with gastric cancer
Authors
KeywordsGlutathione S-Transferase Π
Reactive Oxygen Species
Single Nucleotide Polymorphism
Stomach Neoplasms
Superoxide Dismutase 2
Issue Date2012
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 2012, v. 118 n. 22, p. 5489-5496 How to Cite?
Abstract
BACKGROUND:: Excessive reactive oxygen species (ROS) accumulation is a common phenomenon in carcinogenesis. However, the rationale behind ROS involvement in gastric cancer is unclear. In this study, the authors investigated the clinical significance of the single nucleotide polymorphisms (SNPs) of 2 ROS metabolic process-related genes: superoxide dismutase 2 (SOD2) and glutathione S-transferase π (GSTP1). METHODS:: In total of 929 patients with gastric cancer who had definitive clinicopathologic and follow-up data were collected. SOD2 reference SNP 4880 (rs4880) and GSTP1 rs1695 genotyping were examined in DNA samples extracted from paraffin-embedded tumor tissue. Association of the 2 SNPs with each clinicopathologic feature was analyzed using the Pearson chi-square test and the independent Student t test. Gastric cancer-specific overall survival was analyzed using Kaplan-Meier curves and log-rank tests. Multivariate Cox regression analyses of these SNPs also were performed. RESULTS:: The SOD2 rs4880 CT + CC genotypes were significantly associated with a high level of lymph node metastasis (P = .023), whereas the GSTP1 rs1695 GA + GG genotypes were significantly associated with larger tumor size (>5 cm long; P = .048). Kaplan-Meier and Cox regression data indicated that the SOD2 rs4880 CT + CC genotypes alone (hazard ratio, 1.299; 95% confidence interval, 1.053-1.603; P = .015) and the GSTP1 rs1695 GA + GG combined genotypes (hazard ratio, 1.496; 95% CI, 1.078-2.074; P = .016) were independent predictors for overall survival. CONCLUSIONS:: The current data, based on a large cohort (n = 929) of Chinese patients with gastric cancer, suggested that the presence of SOD2 rs4880 and GSTP1 rs1695 genotypes may contribute to cancer progression as well as tumor aggressiveness. The components of ROS metabolism pathways may be potential therapeutic targets for this aggressive malignancy. Cancer 2012. © 2012 American Cancer Society.
Persistent Identifierhttp://hdl.handle.net/10722/173021
ISSN
2013 Impact Factor: 4.901
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXu, Zen_US
dc.contributor.authorZhu, Hen_US
dc.contributor.authorLuk, JMen_US
dc.contributor.authorWu, Den_US
dc.contributor.authorGu, Den_US
dc.contributor.authorGong, Wen_US
dc.contributor.authorTan, Yen_US
dc.contributor.authorZhou, Jen_US
dc.contributor.authorTang, Jen_US
dc.contributor.authorZhang, Zen_US
dc.contributor.authorWang, Men_US
dc.contributor.authorChen, Jen_US
dc.date.accessioned2012-10-30T06:26:35Z-
dc.date.available2012-10-30T06:26:35Z-
dc.date.issued2012en_US
dc.identifier.citationCancer, 2012, v. 118 n. 22, p. 5489-5496en_US
dc.identifier.issn0008-543Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/173021-
dc.description.abstractBACKGROUND:: Excessive reactive oxygen species (ROS) accumulation is a common phenomenon in carcinogenesis. However, the rationale behind ROS involvement in gastric cancer is unclear. In this study, the authors investigated the clinical significance of the single nucleotide polymorphisms (SNPs) of 2 ROS metabolic process-related genes: superoxide dismutase 2 (SOD2) and glutathione S-transferase π (GSTP1). METHODS:: In total of 929 patients with gastric cancer who had definitive clinicopathologic and follow-up data were collected. SOD2 reference SNP 4880 (rs4880) and GSTP1 rs1695 genotyping were examined in DNA samples extracted from paraffin-embedded tumor tissue. Association of the 2 SNPs with each clinicopathologic feature was analyzed using the Pearson chi-square test and the independent Student t test. Gastric cancer-specific overall survival was analyzed using Kaplan-Meier curves and log-rank tests. Multivariate Cox regression analyses of these SNPs also were performed. RESULTS:: The SOD2 rs4880 CT + CC genotypes were significantly associated with a high level of lymph node metastasis (P = .023), whereas the GSTP1 rs1695 GA + GG genotypes were significantly associated with larger tumor size (>5 cm long; P = .048). Kaplan-Meier and Cox regression data indicated that the SOD2 rs4880 CT + CC genotypes alone (hazard ratio, 1.299; 95% confidence interval, 1.053-1.603; P = .015) and the GSTP1 rs1695 GA + GG combined genotypes (hazard ratio, 1.496; 95% CI, 1.078-2.074; P = .016) were independent predictors for overall survival. CONCLUSIONS:: The current data, based on a large cohort (n = 929) of Chinese patients with gastric cancer, suggested that the presence of SOD2 rs4880 and GSTP1 rs1695 genotypes may contribute to cancer progression as well as tumor aggressiveness. The components of ROS metabolism pathways may be potential therapeutic targets for this aggressive malignancy. Cancer 2012. © 2012 American Cancer Society.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_US
dc.relation.ispartofCanceren_US
dc.subjectGlutathione S-Transferase Πen_US
dc.subjectReactive Oxygen Speciesen_US
dc.subjectSingle Nucleotide Polymorphismen_US
dc.subjectStomach Neoplasmsen_US
dc.subjectSuperoxide Dismutase 2en_US
dc.titleClinical significance of SOD2 and GSTP1 gene polymorphisms in Chinese patients with gastric canceren_US
dc.typeArticleen_US
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_US
dc.identifier.authorityLuk, JM=rp00349en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/cncr.27599en_US
dc.identifier.pmid22517484-
dc.identifier.scopuseid_2-s2.0-84868191177en_US
dc.identifier.isiWOS:000310483800005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridXu, Z=16173739700en_US
dc.identifier.scopusauthoridZhu, H=24729621300en_US
dc.identifier.scopusauthoridLuk, JM=7006777791en_US
dc.identifier.scopusauthoridWu, D=55189567300en_US
dc.identifier.scopusauthoridGu, D=26649912600en_US
dc.identifier.scopusauthoridGong, W=8868454200en_US
dc.identifier.scopusauthoridTan, Y=55110644300en_US
dc.identifier.scopusauthoridZhou, J=35331239900en_US
dc.identifier.scopusauthoridTang, J=7404638892en_US
dc.identifier.scopusauthoridZhang, Z=35265381200en_US
dc.identifier.scopusauthoridWang, M=7406688495en_US
dc.identifier.scopusauthoridChen, J=15080668800en_US

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