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Article: Re-resection for metachronous primary hepatocellular carcinoma: is it justified?

TitleRe-resection for metachronous primary hepatocellular carcinoma: is it justified?
Authors
KeywordsCirrhosis
Hepatectomy
Long-term outcome
Metachronous primary HCC
Resection
Issue Date2012
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ANS
Citation
ANZ Journal of Surgery, 2012, v. 82 n. 1-2, p. 63-67 How to Cite?
AbstractBackground: In management of intrahepatic recurrence of hepatocellular carcinoma (HCC), controversy exists over the efficacy of re-resection for patients with preserved liver function. This study aimed to determine the long-term outcomes of re-resection in these patients. Methods: Prospectively collected data of 47 patients having re-resection (Group R) with curative intent for metachronous primary HCC between December 1989 and December 2007 were compared with those of 863 patients having primary resection (Group P) in the same period. There was no overlap of patient. All patients had gross tumour-free resection margin. Results: The two groups had comparable demographics. Group R had a median age of 58 years (range, 48-67 years), and had almost all patients belonging to Child-Pugh class A (46/47). Median blood loss was 0.66L (range, 0.3-1.28L) for Group P and 0.37L (range, 0.13-0.92L) for Group R. Both groups had median blood transfusion rate at 0. Median operative time was 365min (range, 240-490min) for Group P and 270min (range, 193-360min) for Group R. Group R had significantly fewer tumour nodules and the only one operative death. Median follow-up was 41 months for Group P and 37 months for Group R (P= 0.133). The two groups displayed no significant differences in disease-free survival and overall survival. Univariate analysis showed that re-resection was not a significant risk factor in overall survival. Conclusion: Re-resection for metachronous primary HCC for patients with preserved liver function can achieve favourable survival outcome. © 2011 The Authors. ANZ Journal of Surgery © 2011 Royal Australasian College of Surgeons.
Persistent Identifierhttp://hdl.handle.net/10722/173019
ISSN
2015 Impact Factor: 1.158
2015 SCImago Journal Rankings: 0.432
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChok, KSHen_US
dc.contributor.authorChan, SCen_US
dc.contributor.authorPoon, RTPen_US
dc.contributor.authorFan, STen_US
dc.contributor.authorLo, CMen_US
dc.date.accessioned2012-10-30T06:26:31Z-
dc.date.available2012-10-30T06:26:31Z-
dc.date.issued2012en_US
dc.identifier.citationANZ Journal of Surgery, 2012, v. 82 n. 1-2, p. 63-67en_US
dc.identifier.issn1445-1433en_US
dc.identifier.urihttp://hdl.handle.net/10722/173019-
dc.description.abstractBackground: In management of intrahepatic recurrence of hepatocellular carcinoma (HCC), controversy exists over the efficacy of re-resection for patients with preserved liver function. This study aimed to determine the long-term outcomes of re-resection in these patients. Methods: Prospectively collected data of 47 patients having re-resection (Group R) with curative intent for metachronous primary HCC between December 1989 and December 2007 were compared with those of 863 patients having primary resection (Group P) in the same period. There was no overlap of patient. All patients had gross tumour-free resection margin. Results: The two groups had comparable demographics. Group R had a median age of 58 years (range, 48-67 years), and had almost all patients belonging to Child-Pugh class A (46/47). Median blood loss was 0.66L (range, 0.3-1.28L) for Group P and 0.37L (range, 0.13-0.92L) for Group R. Both groups had median blood transfusion rate at 0. Median operative time was 365min (range, 240-490min) for Group P and 270min (range, 193-360min) for Group R. Group R had significantly fewer tumour nodules and the only one operative death. Median follow-up was 41 months for Group P and 37 months for Group R (P= 0.133). The two groups displayed no significant differences in disease-free survival and overall survival. Univariate analysis showed that re-resection was not a significant risk factor in overall survival. Conclusion: Re-resection for metachronous primary HCC for patients with preserved liver function can achieve favourable survival outcome. © 2011 The Authors. ANZ Journal of Surgery © 2011 Royal Australasian College of Surgeons.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ANSen_US
dc.relation.ispartofANZ Journal of Surgeryen_US
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subjectCirrhosis-
dc.subjectHepatectomy-
dc.subjectLong-term outcome-
dc.subjectMetachronous primary HCC-
dc.subjectResection-
dc.subject.meshTreatment outcomeen_US
dc.subject.meshSurvival analysisen_US
dc.subject.meshRetrospective studiesen_US
dc.subject.meshReoperationen_US
dc.subject.meshNeoplasms, Second primary - mortality - surgeryen_US
dc.subject.meshMultivariate analysisen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshMaleen_US
dc.subject.meshLogistic modelsen_US
dc.subject.meshLiver neoplasms - mortality - surgeryen_US
dc.subject.meshHumansen_US
dc.subject.meshHepatectomyen_US
dc.subject.meshFollow-up studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshCarcinoma, Hepatocellular - mortality - surgeryen_US
dc.subject.meshAgeden_US
dc.titleRe-resection for metachronous primary hepatocellular carcinoma: is it justified?en_US
dc.typeArticleen_US
dc.identifier.emailChok, KSH: kennethchok@yahoo.com.hken_US
dc.identifier.emailChan, SC: chanlsc@hku.hken_US
dc.identifier.emailPoon, RTP: poontp@hku.hken_US
dc.identifier.emailFan, ST: stfan@hku.hken_US
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.authorityChan, SC=rp01568en_US
dc.identifier.authorityPoon, RTP=rp00446en_US
dc.identifier.authorityFan, ST=rp00355en_US
dc.identifier.authorityLo, CM=rp00412en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1445-2197.2011.05931.xen_US
dc.identifier.pmid22507499-
dc.identifier.scopuseid_2-s2.0-84856582035en_US
dc.identifier.hkuros211069-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84856582035&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume82en_US
dc.identifier.issue1-2en_US
dc.identifier.spage63en_US
dc.identifier.epage67en_US
dc.identifier.isiWOS:000299774700017-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridLo, CM=7401771672en_US
dc.identifier.scopusauthoridFan, ST=7402678224en_US
dc.identifier.scopusauthoridPoon, RTP=7103097223en_US
dc.identifier.scopusauthoridChan, SC=7404255575en_US
dc.identifier.scopusauthoridChok, KSH=6508229426en_US

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