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Article: Prospective randomized study of selective neck dissection versus observation for no neck of early tongue carcinoma
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TitleProspective randomized study of selective neck dissection versus observation for no neck of early tongue carcinoma
 
AuthorsYuen, APW3
Chiu, MH1
Tam, LC5
Lap, CT4
Wing, YC1
Ng, RWM3
Wei, WI3
Chi, KK2
Kwok, SB2
Wai, CY6
Lam, AKY8
Yuen, NWF5
TrendellSmith, NJ7
Yue, WC3
Wong, BYH3
Li, GKH3
Ho, ACW3
Wai, KH3
Sau, YW3
Yao, TJ3
 
KeywordsCarcinoma
Dissection
Neck
Randomized
Tongue
 
Issue Date2009
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137
 
CitationHead And Neck, 2009, v. 31 n. 6, p. 765-772 [How to Cite?]
DOI: http://dx.doi.org/10.1002/hed.21033
 
AbstractBackground. There are controversies on the bene-fits of elective neck dissection (END) for oral tongue carcinoma. Method. This is a prospective randomized study of elective selective I, II, III neck dissection versus observation for N0 neck of stage I to II oral tongue carcinoma. There were 35 patients on the observation arm and 36 patients on the END arm. The main outcome assessment parameters are node-related mortality and disease-specific survival rate. Results. There were 11 patients in the observed arm and 2 patients in the END arm who developed nodal recurrence alone without associated local or distant recurrence. All 13 patients were salvaged, and no patient died of nodal recurrence. The 5-year disease-specific survival rate was 87% for the observation arm and was 89% for the END arm; the 2% difference was not significant. Conclusion. Observation may be an acceptable alternative to END if strict adherence to a cancer surveillance protocol is followed. © 2009 Wiley Periodicals, Inc.
 
ISSN1043-3074
2012 Impact Factor: 2.833
2012 SCImago Journal Rankings: 1.110
 
DOIhttp://dx.doi.org/10.1002/hed.21033
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorYuen, APW
 
dc.contributor.authorChiu, MH
 
dc.contributor.authorTam, LC
 
dc.contributor.authorLap, CT
 
dc.contributor.authorWing, YC
 
dc.contributor.authorNg, RWM
 
dc.contributor.authorWei, WI
 
dc.contributor.authorChi, KK
 
dc.contributor.authorKwok, SB
 
dc.contributor.authorWai, CY
 
dc.contributor.authorLam, AKY
 
dc.contributor.authorYuen, NWF
 
dc.contributor.authorTrendellSmith, NJ
 
dc.contributor.authorYue, WC
 
dc.contributor.authorWong, BYH
 
dc.contributor.authorLi, GKH
 
dc.contributor.authorHo, ACW
 
dc.contributor.authorWai, KH
 
dc.contributor.authorSau, YW
 
dc.contributor.authorYao, TJ
 
dc.date.accessioned2012-10-30T06:26:14Z
 
dc.date.available2012-10-30T06:26:14Z
 
dc.date.issued2009
 
dc.description.abstractBackground. There are controversies on the bene-fits of elective neck dissection (END) for oral tongue carcinoma. Method. This is a prospective randomized study of elective selective I, II, III neck dissection versus observation for N0 neck of stage I to II oral tongue carcinoma. There were 35 patients on the observation arm and 36 patients on the END arm. The main outcome assessment parameters are node-related mortality and disease-specific survival rate. Results. There were 11 patients in the observed arm and 2 patients in the END arm who developed nodal recurrence alone without associated local or distant recurrence. All 13 patients were salvaged, and no patient died of nodal recurrence. The 5-year disease-specific survival rate was 87% for the observation arm and was 89% for the END arm; the 2% difference was not significant. Conclusion. Observation may be an acceptable alternative to END if strict adherence to a cancer surveillance protocol is followed. © 2009 Wiley Periodicals, Inc.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationHead And Neck, 2009, v. 31 n. 6, p. 765-772 [How to Cite?]
DOI: http://dx.doi.org/10.1002/hed.21033
 
dc.identifier.doihttp://dx.doi.org/10.1002/hed.21033
 
dc.identifier.epage772
 
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2012 SCImago Journal Rankings: 1.110
 
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dc.identifier.spage765
 
dc.identifier.urihttp://hdl.handle.net/10722/172987
 
dc.identifier.volume31
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137
 
dc.publisher.placeUnited States
 
dc.relation.ispartofHead and Neck
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshAged, 80 And Over
 
dc.subject.meshCarcinoma, Squamous Cell - Mortality - Pathology - Surgery - Therapy
 
dc.subject.meshChi-Square Distribution
 
dc.subject.meshDisease-Free Survival
 
dc.subject.meshFemale
 
dc.subject.meshFollow-Up Studies
 
dc.subject.meshHumans
 
dc.subject.meshKaplan-Meier Estimate
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshMonitoring, Physiologic - Methods
 
dc.subject.meshNeck Dissection - Methods
 
dc.subject.meshNeoplasm Recurrence, Local - Mortality - Pathology
 
dc.subject.meshNeoplasm Staging
 
dc.subject.meshObservation - Methods
 
dc.subject.meshPatient Selection
 
dc.subject.meshProspective Studies
 
dc.subject.meshReference Values
 
dc.subject.meshRisk Assessment
 
dc.subject.meshSurvival Analysis
 
dc.subject.meshTongue Neoplasms - Mortality - Pathology - Surgery - Therapy
 
dc.subject.meshTreatment Outcome
 
dc.subjectCarcinoma
 
dc.subjectDissection
 
dc.subjectNeck
 
dc.subjectRandomized
 
dc.subjectTongue
 
dc.titleProspective randomized study of selective neck dissection versus observation for no neck of early tongue carcinoma
 
dc.typeArticle
 
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<description.abstract>Background. There are controversies on the bene-fits of elective neck dissection (END) for oral tongue carcinoma. Method. This is a prospective randomized study of elective selective I, II, III neck dissection versus observation for N0 neck of stage I to II oral tongue carcinoma. There were 35 patients on the observation arm and 36 patients on the END arm. The main outcome assessment parameters are node-related mortality and disease-specific survival rate. Results. There were 11 patients in the observed arm and 2 patients in the END arm who developed nodal recurrence alone without associated local or distant recurrence. All 13 patients were salvaged, and no patient died of nodal recurrence. The 5-year disease-specific survival rate was 87% for the observation arm and was 89% for the END arm; the 2% difference was not significant. Conclusion. Observation may be an acceptable alternative to END if strict adherence to a cancer surveillance protocol is followed. &#169; 2009 Wiley Periodicals, Inc.</description.abstract>
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Author Affiliations
  1. Kwong Wah Hospital
  2. Yan Chai Hospital - Hong Kong
  3. The University of Hong Kong
  4. Queen Elizabeth Hospital Hong Kong
  5. United Christian Hospital Hong Kong
  6. Ruttonjee Hospital Hong Kong
  7. Queen Mary Hospital Hong Kong
  8. Griffith University