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Article: Is radiofrequency ablation the treatment of choice for patients with small hepatocellular carcinoma?

TitleIs radiofrequency ablation the treatment of choice for patients with small hepatocellular carcinoma?
Authors
Issue Date2008
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ncpgasthep/
Citation
Nature Clinical Practice Gastroenterology And Hepatology, 2008, v. 5 n. 9, p. 492-493 How to Cite?
AbstractLiver resection is widely considered the mainstay of curative therapy for small hepatocellular carcinoma (HCC). Radiofrequency ablation (RFA) was initially developed as a treatment for small HCC in patients with considerable cirrhosis and inadequate liver function reserve for liver resection. However, in some centers, RFA is now used for small HCC, as an alternative to liver resection or even as the preferred treatment. This Practice Point commentary discusses the findings and limitations of a retrospective cohort study by Livraghi et al. that analyzed the outcomes of a group of patients with small, single HCC who underwent treatment with RFA. The authors reported a low major complication rate and a local complete response rate similar to that after resection. This commentary highlights the issues to consider when interpreting and generalizing these results, in particular that these findings need to be interpreted in the light of studies that suggest a high rate of local recurrence and incomplete histopathological response after RFA of small HCC.
Persistent Identifierhttp://hdl.handle.net/10722/172977
ISSN
2011 Impact Factor: 5.333
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPoon, RTPen_US
dc.date.accessioned2012-10-30T06:26:10Z-
dc.date.available2012-10-30T06:26:10Z-
dc.date.issued2008en_US
dc.identifier.citationNature Clinical Practice Gastroenterology And Hepatology, 2008, v. 5 n. 9, p. 492-493en_US
dc.identifier.issn1743-4378en_US
dc.identifier.urihttp://hdl.handle.net/10722/172977-
dc.description.abstractLiver resection is widely considered the mainstay of curative therapy for small hepatocellular carcinoma (HCC). Radiofrequency ablation (RFA) was initially developed as a treatment for small HCC in patients with considerable cirrhosis and inadequate liver function reserve for liver resection. However, in some centers, RFA is now used for small HCC, as an alternative to liver resection or even as the preferred treatment. This Practice Point commentary discusses the findings and limitations of a retrospective cohort study by Livraghi et al. that analyzed the outcomes of a group of patients with small, single HCC who underwent treatment with RFA. The authors reported a low major complication rate and a local complete response rate similar to that after resection. This commentary highlights the issues to consider when interpreting and generalizing these results, in particular that these findings need to be interpreted in the light of studies that suggest a high rate of local recurrence and incomplete histopathological response after RFA of small HCC.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ncpgasthep/en_US
dc.relation.ispartofNature Clinical Practice Gastroenterology and Hepatologyen_US
dc.titleIs radiofrequency ablation the treatment of choice for patients with small hepatocellular carcinoma?en_US
dc.typeArticleen_US
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_US
dc.identifier.authorityPoon, RTP=rp00446en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/ncpgasthep1204en_US
dc.identifier.pmid18628733-
dc.identifier.scopuseid_2-s2.0-51349161175en_US
dc.identifier.hkuros167148-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-51349161175&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume5en_US
dc.identifier.issue9en_US
dc.identifier.spage492en_US
dc.identifier.epage493en_US
dc.identifier.isiWOS:000258829000007-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridPoon, RTP=7103097223en_US

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