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Article: Serum vascular endothelial growth factor C correlates with lymph node metastases and high-risk tumor profiles in papillary thyroid carcinoma.

TitleSerum vascular endothelial growth factor C correlates with lymph node metastases and high-risk tumor profiles in papillary thyroid carcinoma.
Authors
Issue Date2008
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.com
Citation
Annals Of Surgery, 2008, v. 247 n. 3, p. 483-489 How to Cite?
AbstractOBJECTIVE: To evaluate the clinical relevance of serum vascular endothelial growth factor (VEGF) and VEGF-C in papillary thyroid carcinoma (PTC). SUMMARY BACKGROUND DATA: VEGF is a potent angiogenic factor promoting tumor angioinvasion and distant metastases, whereas VEGF-C enhances nodal metastases because of its lymphangiogenic effect. Although both tissues VEGF and VEGF-C have been shown to contribute to tumor metastases in PTC, the clinical relevance of serum VEGF (sVEGF) and sVEGF-C remains unknown. METHODS: Preoperative serum samples collected from 85 primary PTC patients and 44 control subjects with benign thyroid diseases were measured for sVEGF and sVEGF-C levels. Potential correlations between their serum levels and clinicopathologic features as well as the commonly adopted risk group stratification profiles of the tumors were analyzed. RESULTS: Preoperative sVEGF and sVEGF-C levels of PTC patients were significantly higher compared with those of control subjects (P = 0.001 and P < 0.001, respectively). sVEGF-C level was significantly elevated in older patients, those with extrathyroidal invasion and with lymph node metastases whereas sVEGF level was significantly increased in multifocal tumors. sVEGF-C, but not sVEGF, correlated significantly with high risk tumors in all commonly adopted risk group stratification profiles. An elevated preoperative sVEGF-C level of >7200 pg/mL was shown to be the only independent risk factor for nodal metastases. sVEGF-C levels declined significantly at 3 months after thyroidectomy in PTC but not control patients. CONCLUSIONS: sVEGF-C levels in PTC patients correlated significantly with the presence of nodal metastases and advanced tumor stages. Its clinical relevance needs further evaluation.
Persistent Identifierhttp://hdl.handle.net/10722/172964
ISSN
2015 Impact Factor: 8.569
2015 SCImago Journal Rankings: 4.503
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYu, XMen_US
dc.contributor.authorLo, CYen_US
dc.contributor.authorLam, AKYen_US
dc.contributor.authorLeung, Pen_US
dc.contributor.authorLuk, JMen_US
dc.date.accessioned2012-10-30T06:26:05Z-
dc.date.available2012-10-30T06:26:05Z-
dc.date.issued2008en_US
dc.identifier.citationAnnals Of Surgery, 2008, v. 247 n. 3, p. 483-489en_US
dc.identifier.issn0003-4932en_US
dc.identifier.urihttp://hdl.handle.net/10722/172964-
dc.description.abstractOBJECTIVE: To evaluate the clinical relevance of serum vascular endothelial growth factor (VEGF) and VEGF-C in papillary thyroid carcinoma (PTC). SUMMARY BACKGROUND DATA: VEGF is a potent angiogenic factor promoting tumor angioinvasion and distant metastases, whereas VEGF-C enhances nodal metastases because of its lymphangiogenic effect. Although both tissues VEGF and VEGF-C have been shown to contribute to tumor metastases in PTC, the clinical relevance of serum VEGF (sVEGF) and sVEGF-C remains unknown. METHODS: Preoperative serum samples collected from 85 primary PTC patients and 44 control subjects with benign thyroid diseases were measured for sVEGF and sVEGF-C levels. Potential correlations between their serum levels and clinicopathologic features as well as the commonly adopted risk group stratification profiles of the tumors were analyzed. RESULTS: Preoperative sVEGF and sVEGF-C levels of PTC patients were significantly higher compared with those of control subjects (P = 0.001 and P < 0.001, respectively). sVEGF-C level was significantly elevated in older patients, those with extrathyroidal invasion and with lymph node metastases whereas sVEGF level was significantly increased in multifocal tumors. sVEGF-C, but not sVEGF, correlated significantly with high risk tumors in all commonly adopted risk group stratification profiles. An elevated preoperative sVEGF-C level of >7200 pg/mL was shown to be the only independent risk factor for nodal metastases. sVEGF-C levels declined significantly at 3 months after thyroidectomy in PTC but not control patients. CONCLUSIONS: sVEGF-C levels in PTC patients correlated significantly with the presence of nodal metastases and advanced tumor stages. Its clinical relevance needs further evaluation.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.comen_US
dc.relation.ispartofAnnals of surgeryen_US
dc.rightsAnnals of Surgery. Copyright © Lippincott Williams & Wilkins.-
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshCarcinoma, Papillary - Blood - Surgeryen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphatic Metastasis - Diagnosisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshThyroid Diseases - Blooden_US
dc.subject.meshThyroid Neoplasms - Blood - Surgeryen_US
dc.subject.meshThyroidectomyen_US
dc.subject.meshVascular Endothelial Growth Factor A - Blooden_US
dc.subject.meshVascular Endothelial Growth Factor C - Blooden_US
dc.titleSerum vascular endothelial growth factor C correlates with lymph node metastases and high-risk tumor profiles in papillary thyroid carcinoma.en_US
dc.typeArticleen_US
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_US
dc.identifier.authorityLuk, JM=rp00349en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/SLA.0b013e31815fa447-
dc.identifier.pmid18376194-
dc.identifier.scopuseid_2-s2.0-42249087955en_US
dc.identifier.hkuros141637-
dc.identifier.volume247en_US
dc.identifier.issue3en_US
dc.identifier.spage483en_US
dc.identifier.epage489en_US
dc.identifier.isiWOS:000253436200014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYu, XM=9534691000en_US
dc.identifier.scopusauthoridLo, CY=16417392800en_US
dc.identifier.scopusauthoridLam, AK=7403657165en_US
dc.identifier.scopusauthoridLeung, P=7401749062en_US
dc.identifier.scopusauthoridLuk, JM=7006777791en_US

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