File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1097/SLA.0b013e31815fa447
- Scopus: eid_2-s2.0-42249087955
- PMID: 18376194
- WOS: WOS:000253436200014
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Serum vascular endothelial growth factor C correlates with lymph node metastases and high-risk tumor profiles in papillary thyroid carcinoma.
Title | Serum vascular endothelial growth factor C correlates with lymph node metastases and high-risk tumor profiles in papillary thyroid carcinoma. |
---|---|
Authors | |
Issue Date | 2008 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.com |
Citation | Annals Of Surgery, 2008, v. 247 n. 3, p. 483-489 How to Cite? |
Abstract | OBJECTIVE: To evaluate the clinical relevance of serum vascular endothelial growth factor (VEGF) and VEGF-C in papillary thyroid carcinoma (PTC). SUMMARY BACKGROUND DATA: VEGF is a potent angiogenic factor promoting tumor angioinvasion and distant metastases, whereas VEGF-C enhances nodal metastases because of its lymphangiogenic effect. Although both tissues VEGF and VEGF-C have been shown to contribute to tumor metastases in PTC, the clinical relevance of serum VEGF (sVEGF) and sVEGF-C remains unknown. METHODS: Preoperative serum samples collected from 85 primary PTC patients and 44 control subjects with benign thyroid diseases were measured for sVEGF and sVEGF-C levels. Potential correlations between their serum levels and clinicopathologic features as well as the commonly adopted risk group stratification profiles of the tumors were analyzed. RESULTS: Preoperative sVEGF and sVEGF-C levels of PTC patients were significantly higher compared with those of control subjects (P = 0.001 and P < 0.001, respectively). sVEGF-C level was significantly elevated in older patients, those with extrathyroidal invasion and with lymph node metastases whereas sVEGF level was significantly increased in multifocal tumors. sVEGF-C, but not sVEGF, correlated significantly with high risk tumors in all commonly adopted risk group stratification profiles. An elevated preoperative sVEGF-C level of >7200 pg/mL was shown to be the only independent risk factor for nodal metastases. sVEGF-C levels declined significantly at 3 months after thyroidectomy in PTC but not control patients. CONCLUSIONS: sVEGF-C levels in PTC patients correlated significantly with the presence of nodal metastases and advanced tumor stages. Its clinical relevance needs further evaluation. |
Persistent Identifier | http://hdl.handle.net/10722/172964 |
ISSN | 2023 Impact Factor: 7.5 2023 SCImago Journal Rankings: 2.729 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yu, XM | en_US |
dc.contributor.author | Lo, CY | en_US |
dc.contributor.author | Lam, AKY | en_US |
dc.contributor.author | Leung, P | en_US |
dc.contributor.author | Luk, JM | en_US |
dc.date.accessioned | 2012-10-30T06:26:05Z | - |
dc.date.available | 2012-10-30T06:26:05Z | - |
dc.date.issued | 2008 | en_US |
dc.identifier.citation | Annals Of Surgery, 2008, v. 247 n. 3, p. 483-489 | en_US |
dc.identifier.issn | 0003-4932 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/172964 | - |
dc.description.abstract | OBJECTIVE: To evaluate the clinical relevance of serum vascular endothelial growth factor (VEGF) and VEGF-C in papillary thyroid carcinoma (PTC). SUMMARY BACKGROUND DATA: VEGF is a potent angiogenic factor promoting tumor angioinvasion and distant metastases, whereas VEGF-C enhances nodal metastases because of its lymphangiogenic effect. Although both tissues VEGF and VEGF-C have been shown to contribute to tumor metastases in PTC, the clinical relevance of serum VEGF (sVEGF) and sVEGF-C remains unknown. METHODS: Preoperative serum samples collected from 85 primary PTC patients and 44 control subjects with benign thyroid diseases were measured for sVEGF and sVEGF-C levels. Potential correlations between their serum levels and clinicopathologic features as well as the commonly adopted risk group stratification profiles of the tumors were analyzed. RESULTS: Preoperative sVEGF and sVEGF-C levels of PTC patients were significantly higher compared with those of control subjects (P = 0.001 and P < 0.001, respectively). sVEGF-C level was significantly elevated in older patients, those with extrathyroidal invasion and with lymph node metastases whereas sVEGF level was significantly increased in multifocal tumors. sVEGF-C, but not sVEGF, correlated significantly with high risk tumors in all commonly adopted risk group stratification profiles. An elevated preoperative sVEGF-C level of >7200 pg/mL was shown to be the only independent risk factor for nodal metastases. sVEGF-C levels declined significantly at 3 months after thyroidectomy in PTC but not control patients. CONCLUSIONS: sVEGF-C levels in PTC patients correlated significantly with the presence of nodal metastases and advanced tumor stages. Its clinical relevance needs further evaluation. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.com | en_US |
dc.relation.ispartof | Annals of surgery | en_US |
dc.rights | Annals of Surgery. Copyright © Lippincott Williams & Wilkins. | - |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Age Factors | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Aged, 80 And Over | en_US |
dc.subject.mesh | Carcinoma, Papillary - Blood - Surgery | en_US |
dc.subject.mesh | Enzyme-Linked Immunosorbent Assay | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Lymphatic Metastasis - Diagnosis | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Risk Factors | en_US |
dc.subject.mesh | Thyroid Diseases - Blood | en_US |
dc.subject.mesh | Thyroid Neoplasms - Blood - Surgery | en_US |
dc.subject.mesh | Thyroidectomy | en_US |
dc.subject.mesh | Vascular Endothelial Growth Factor A - Blood | en_US |
dc.subject.mesh | Vascular Endothelial Growth Factor C - Blood | en_US |
dc.title | Serum vascular endothelial growth factor C correlates with lymph node metastases and high-risk tumor profiles in papillary thyroid carcinoma. | en_US |
dc.type | Article | en_US |
dc.identifier.email | Luk, JM: jmluk@hkucc.hku.hk | en_US |
dc.identifier.authority | Luk, JM=rp00349 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1097/SLA.0b013e31815fa447 | - |
dc.identifier.pmid | 18376194 | - |
dc.identifier.scopus | eid_2-s2.0-42249087955 | en_US |
dc.identifier.hkuros | 141637 | - |
dc.identifier.volume | 247 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 483 | en_US |
dc.identifier.epage | 489 | en_US |
dc.identifier.isi | WOS:000253436200014 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Yu, XM=9534691000 | en_US |
dc.identifier.scopusauthorid | Lo, CY=16417392800 | en_US |
dc.identifier.scopusauthorid | Lam, AK=7403657165 | en_US |
dc.identifier.scopusauthorid | Leung, P=7401749062 | en_US |
dc.identifier.scopusauthorid | Luk, JM=7006777791 | en_US |
dc.identifier.issnl | 0003-4932 | - |