File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: GEP associates with wild-type p53 in hepatocellular carcinoma.

TitleGEP associates with wild-type p53 in hepatocellular carcinoma.
Authors
Issue Date2006
PublisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htm
Citation
Oncology Reports, 2006, v. 15 n. 6, p. 1507-1511 How to Cite?
AbstractGranulin-epithelin precursor (GEP) is a novel growth factor whose up-regulation we previously reported in 72% of hepatocellular carcinoma (HCC). GEP expression has been reported to be associated with p53 protein accumulation in a breast cancer study, though the p53 mutation status was not revealed. We aim to investigate whether p53 protein and mutation status correlates with GEP expression in HCC. The statistical comparison of p53 and GEP data revealed an overall positive association between the two protein expression patterns (P<0.001). Upon detailed analysis, the association of p53 and GEP protein expression was found to be highly significant only in HCCs with wild-type p53 (P=0.001); there was no association in HCCs with p53 mutation (P=0.669). The GEP levels in the HepG2 hepatoma cell line with a wild-type p53 background were modulated by transfection experiments. Overexpression of the GEP protein resulted in an increased p53 protein level and suppression of the GEP protein resulted in a decreased p53 protein level in HepG2 cells. In summary, we demonstrated that p53 wild-type protein nuclei accumulation is associated with GEP protein expression in human HCC specimens, and GEP modulates p53 wild-type protein levels in vitro.
Persistent Identifierhttp://hdl.handle.net/10722/172958
ISSN
2015 Impact Factor: 2.486
2015 SCImago Journal Rankings: 0.968
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheung, STen_US
dc.contributor.authorWong, SYen_US
dc.contributor.authorLee, YTen_US
dc.contributor.authorFan, STen_US
dc.date.accessioned2012-10-30T06:26:02Z-
dc.date.available2012-10-30T06:26:02Z-
dc.date.issued2006en_US
dc.identifier.citationOncology Reports, 2006, v. 15 n. 6, p. 1507-1511en_US
dc.identifier.issn1021-335Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/172958-
dc.description.abstractGranulin-epithelin precursor (GEP) is a novel growth factor whose up-regulation we previously reported in 72% of hepatocellular carcinoma (HCC). GEP expression has been reported to be associated with p53 protein accumulation in a breast cancer study, though the p53 mutation status was not revealed. We aim to investigate whether p53 protein and mutation status correlates with GEP expression in HCC. The statistical comparison of p53 and GEP data revealed an overall positive association between the two protein expression patterns (P<0.001). Upon detailed analysis, the association of p53 and GEP protein expression was found to be highly significant only in HCCs with wild-type p53 (P=0.001); there was no association in HCCs with p53 mutation (P=0.669). The GEP levels in the HepG2 hepatoma cell line with a wild-type p53 background were modulated by transfection experiments. Overexpression of the GEP protein resulted in an increased p53 protein level and suppression of the GEP protein resulted in a decreased p53 protein level in HepG2 cells. In summary, we demonstrated that p53 wild-type protein nuclei accumulation is associated with GEP protein expression in human HCC specimens, and GEP modulates p53 wild-type protein levels in vitro.en_US
dc.languageengen_US
dc.publisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htmen_US
dc.relation.ispartofOncology reportsen_US
dc.subject.meshCarcinoma, Hepatocellular - Genetics - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshIntercellular Signaling Peptides And Proteins - Biosynthesis - Genetics - Metabolismen_US
dc.subject.meshLiver Neoplasms - Genetics - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMutationen_US
dc.subject.meshTransfectionen_US
dc.subject.meshTumor Suppressor Protein P53 - Biosynthesis - Genetics - Metabolismen_US
dc.titleGEP associates with wild-type p53 in hepatocellular carcinoma.en_US
dc.typeArticleen_US
dc.identifier.emailCheung, ST: stcheung@hkucc.hku.hken_US
dc.identifier.emailFan, ST: stfan@hku.hken_US
dc.identifier.authorityCheung, ST=rp00457en_US
dc.identifier.authorityFan, ST=rp00355en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid16685387-
dc.identifier.scopuseid_2-s2.0-39049195644en_US
dc.identifier.hkuros116946-
dc.identifier.volume15en_US
dc.identifier.issue6en_US
dc.identifier.spage1507en_US
dc.identifier.epage1511en_US
dc.identifier.isiWOS:000237873300015-
dc.publisher.placeGreeceen_US
dc.identifier.scopusauthoridCheung, ST=7202473497en_US
dc.identifier.scopusauthoridWong, SY=7404590342en_US
dc.identifier.scopusauthoridLee, YT=22734702300en_US
dc.identifier.scopusauthoridFan, ST=7402678224en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats