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Article: Triology of neurosurgical complications after radiotherapy for nasopharyngeal carcinoma

TitleTriology of neurosurgical complications after radiotherapy for nasopharyngeal carcinoma
Authors
Issue Date2007
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/surneu
Citation
Surgical Neurology, 2007, v. 68 n. 4, p. 466-470 How to Cite?
AbstractBackground: Radiotherapy is an effective treatment for NPC. With improved survival, radiation-induced neurological complications are being diagnosed more commonly. We presented a patient with a trilogy of radiation-induced pathologies after radiotherapy for NPC. The diagnostic and surgical implications are discussed. Case Description: A 57-year-old man, previously irradiated for NPC, presented with mental confusion and was found to have radiation-induced carotid stenosis and bitemporal lobe necrosis on MR imaging. His condition deteriorated suddenly a year later, and a gliosarcoma was found to have developed within the area of right temporal lobe necrosis. Tumor removal was complicated by injury to the MCA branches, causing basal ganglion infarction. This was likely because of a combination of technical error and arterial insufficiency secondary to radiation-induced arterial stenosis. Conclusions: In patients with known temporal lobe radiation-induced necrosis, alternative diagnosis such as gliosarcoma should be considered when there is sudden clinical deterioration. Radiation-induced carotid stenosis may reduce the safety margin during surgery. Preoperative carotid screening may be indicated. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/172949
ISSN
2011 Impact Factor: 1.669
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, GKKen_US
dc.contributor.authorChan, SKen_US
dc.contributor.authorHung, KNen_US
dc.date.accessioned2012-10-30T06:25:58Z-
dc.date.available2012-10-30T06:25:58Z-
dc.date.issued2007en_US
dc.identifier.citationSurgical Neurology, 2007, v. 68 n. 4, p. 466-470en_US
dc.identifier.issn0090-3019en_US
dc.identifier.urihttp://hdl.handle.net/10722/172949-
dc.description.abstractBackground: Radiotherapy is an effective treatment for NPC. With improved survival, radiation-induced neurological complications are being diagnosed more commonly. We presented a patient with a trilogy of radiation-induced pathologies after radiotherapy for NPC. The diagnostic and surgical implications are discussed. Case Description: A 57-year-old man, previously irradiated for NPC, presented with mental confusion and was found to have radiation-induced carotid stenosis and bitemporal lobe necrosis on MR imaging. His condition deteriorated suddenly a year later, and a gliosarcoma was found to have developed within the area of right temporal lobe necrosis. Tumor removal was complicated by injury to the MCA branches, causing basal ganglion infarction. This was likely because of a combination of technical error and arterial insufficiency secondary to radiation-induced arterial stenosis. Conclusions: In patients with known temporal lobe radiation-induced necrosis, alternative diagnosis such as gliosarcoma should be considered when there is sudden clinical deterioration. Radiation-induced carotid stenosis may reduce the safety margin during surgery. Preoperative carotid screening may be indicated. © 2007 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/surneuen_US
dc.relation.ispartofSurgical Neurologyen_US
dc.rightsSurgical Neurology. Copyright © Elsevier Inc.-
dc.subject.meshBrain Neoplasms - Pathology - Surgeryen_US
dc.subject.meshCarotid Stenosis - Etiology - Surgeryen_US
dc.subject.meshConfusion - Etiologyen_US
dc.subject.meshGliosarcoma - Pathology - Surgeryen_US
dc.subject.meshHumansen_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNasopharyngeal Neoplasms - Complications - Radiotherapyen_US
dc.subject.meshNecrosisen_US
dc.subject.meshNeoplasms, Radiation-Induced - Surgeryen_US
dc.subject.meshNervous System Diseases - Etiology - Psychology - Surgeryen_US
dc.subject.meshNeurosurgical Proceduresen_US
dc.subject.meshRadiotherapy - Adverse Effectsen_US
dc.subject.meshStentsen_US
dc.subject.meshTemporal Lobe - Pathology - Surgeryen_US
dc.titleTriology of neurosurgical complications after radiotherapy for nasopharyngeal carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailLeung, GKK: gilberto@hkucc.hku.hken_US
dc.identifier.authorityLeung, GKK=rp00522en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.surneu.2006.10.066en_US
dc.identifier.pmid17905078-
dc.identifier.scopuseid_2-s2.0-34848818813en_US
dc.identifier.hkuros139663-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34848818813&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume68en_US
dc.identifier.issue4en_US
dc.identifier.spage466en_US
dc.identifier.epage470en_US
dc.identifier.isiWOS:000250158400028-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLeung, GKK=35965118200en_US
dc.identifier.scopusauthoridChan, SK=8689740000en_US
dc.identifier.scopusauthoridHung, KN=7202728375en_US

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