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Article: Radiofrequency ablation for hepatocellular carcinoma and metastatic liver tumors: A comparative study

TitleRadiofrequency ablation for hepatocellular carcinoma and metastatic liver tumors: A comparative study
Authors
Issue Date2006
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31873
Citation
Journal Of Surgical Oncology, 2006, v. 94 n. 7, p. 565-571 How to Cite?
AbstractBackground: This study compared the effectiveness of radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) and liver metastases. Methods: We compared the outcomes of 240 patients with HCC and 44 patients with liver metastases treated with RFA. Data were prospectively collected and retrospectively analyzed. Effects of different variables on recurrences were studied. Results: A total of 406 tumor nodules were treated. The median size of the largest ablated tumor was 2.5 cm, and the median tumor number was 1. Complete tumor ablation was achieved in 91.2%. Local recurrence rate was 15.4% after a median follow-up of 24.5 months. There was no significant impact of tumor pathology on local recurrence. However, patients with liver metastasis had higher extrahepatic recurrence rate (P = 0.019) and shorter disease-free survival (P = 0.007). Patients with multiple tumors had higher local (P = 0.047) and extrahepatic (P = 0.019) recurrence rates than those with a solitary tumor. Tumor size had an impact on local recurrence rate only in patients with liver metastasis with a higher rate in those with tumor >2.5 cm in diameter (P = 0.028). Conclusions: Tumor pathology does not appear to have a significant impact on local recurrence rates. RFA is effective in local tumor control for both HCC and liver metastasis. © 2006 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/172933
ISSN
2015 Impact Factor: 3.151
2015 SCImago Journal Rankings: 1.349
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChow, DHFen_US
dc.contributor.authorSinn, LHYen_US
dc.contributor.authorNg, KKen_US
dc.contributor.authorLam, CMen_US
dc.contributor.authorYuen, Jen_US
dc.contributor.authorFan, STen_US
dc.contributor.authorPoon, RTPen_US
dc.date.accessioned2012-10-30T06:25:53Z-
dc.date.available2012-10-30T06:25:53Z-
dc.date.issued2006en_US
dc.identifier.citationJournal Of Surgical Oncology, 2006, v. 94 n. 7, p. 565-571en_US
dc.identifier.issn0022-4790en_US
dc.identifier.urihttp://hdl.handle.net/10722/172933-
dc.description.abstractBackground: This study compared the effectiveness of radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) and liver metastases. Methods: We compared the outcomes of 240 patients with HCC and 44 patients with liver metastases treated with RFA. Data were prospectively collected and retrospectively analyzed. Effects of different variables on recurrences were studied. Results: A total of 406 tumor nodules were treated. The median size of the largest ablated tumor was 2.5 cm, and the median tumor number was 1. Complete tumor ablation was achieved in 91.2%. Local recurrence rate was 15.4% after a median follow-up of 24.5 months. There was no significant impact of tumor pathology on local recurrence. However, patients with liver metastasis had higher extrahepatic recurrence rate (P = 0.019) and shorter disease-free survival (P = 0.007). Patients with multiple tumors had higher local (P = 0.047) and extrahepatic (P = 0.019) recurrence rates than those with a solitary tumor. Tumor size had an impact on local recurrence rate only in patients with liver metastasis with a higher rate in those with tumor >2.5 cm in diameter (P = 0.028). Conclusions: Tumor pathology does not appear to have a significant impact on local recurrence rates. RFA is effective in local tumor control for both HCC and liver metastasis. © 2006 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31873en_US
dc.relation.ispartofJournal of Surgical Oncologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshCarcinoma, Hepatocellular - Secondary - Surgeryen_US
dc.subject.meshCatheter Ablationen_US
dc.subject.meshColorectal Neoplasms - Secondaryen_US
dc.subject.meshDisease-Free Survivalen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatectomy - Methodsen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Neoplasms - Pathology - Surgeryen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Recurrence, Localen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleRadiofrequency ablation for hepatocellular carcinoma and metastatic liver tumors: A comparative studyen_US
dc.typeArticleen_US
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_US
dc.identifier.authorityPoon, RTP=rp00446en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/jso.20674en_US
dc.identifier.pmid17048238-
dc.identifier.scopuseid_2-s2.0-33845223202en_US
dc.identifier.hkuros125005-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33845223202&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume94en_US
dc.identifier.issue7en_US
dc.identifier.spage565en_US
dc.identifier.epage571en_US
dc.identifier.isiWOS:000242223700006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChow, DHF=35979710900en_US
dc.identifier.scopusauthoridSinn, LHY=15122688500en_US
dc.identifier.scopusauthoridNg, KK=35248894000en_US
dc.identifier.scopusauthoridChi, ML=8343493900en_US
dc.identifier.scopusauthoridYuen, J=7102620431en_US
dc.identifier.scopusauthoridSheung, TF=6506234707en_US
dc.identifier.scopusauthoridPoon, RTP=7103097223en_US

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