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Article: Genetic analysis of CYP2D6 locus of Hong Kong Chinese psychiatric patients

TitleGenetic analysis of CYP2D6 locus of Hong Kong Chinese psychiatric patients
Authors
Issue Date1998
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 1998, v. 81 n. 6, p. 527 How to Cite?
AbstractThe genetically determined polymorphism of debrisoquine hydroxylase (cytochrome P4502D6, CYP2D6) shows marked interethnic differences due to the different distribution of the alleles of the CYP2D6 gene in different populations. Differences are not only in the incidence of poor metabolizers (PM) of debrisoquone, but also in the enzyme activity within the extensive metabolizer (EM) phenotype. The distribution of the debrisoquine metabolic ratios (MR) is shifted towards higher values among Oriental EMs compared to Caucasian EMs due to the high prevalence of the CYP2D6*10 allele [nomenclature according to Daly et al., 1996] in this population [Wang et al., 1993]. The prevalence of the different alleles of the CYP2D6 gene may be different within different Oriental populations or in particular patient groups. The genotype of 54 patients with diagnosis of major depression according to DSM IV was assessed for the prevalence of the alleles CYP2D6*10, CYP2D6*4, and CYP2D6*8 (the prevalence of which in Chinese is not known). Mutation 2938C→T indicative of CYP2D6*2 (allele L) was also assessed in five patients homozygous for CYP2D6*10 and was found to be absent. Genotyping was performed according to published methods. The CYP2D6*8 and CYP2D6*4 alleles were absent in the present population studied as expected. The CYP2D6*10 allele frequency was 0.6 in the present study, similar to that found among Singaporean Chinese, higher than that found among the Japanese, Koreans, and Chinese living in Sweden (0.51), and lower than that among Taiwanese (0.7) [Wang et al., 1993; Yokota et al., 1993; Lee and Jeyaseelan, 1994; Roh et al., 1996]. Genotyping a healthy Hong Kong Chinese population and testing for other variants of the CYP2D6 gene is in progress. This is the first CYP2D6 genotyping study conducted on a Hong Kong Chinese population. It will contribute to previous data on differences among EMs of different Oriental origins.
Persistent Identifierhttp://hdl.handle.net/10722/172926
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771

 

DC FieldValueLanguage
dc.contributor.authorGarciaBarcelo, MMen_US
dc.contributor.authorChiu, HFKen_US
dc.contributor.authorWing, YKen_US
dc.contributor.authorChow, LYen_US
dc.contributor.authorLam, KLen_US
dc.contributor.authorWaye, MMYen_US
dc.date.accessioned2012-10-30T06:25:50Z-
dc.date.available2012-10-30T06:25:50Z-
dc.date.issued1998en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 1998, v. 81 n. 6, p. 527en_US
dc.identifier.issn1552-4841en_US
dc.identifier.urihttp://hdl.handle.net/10722/172926-
dc.description.abstractThe genetically determined polymorphism of debrisoquine hydroxylase (cytochrome P4502D6, CYP2D6) shows marked interethnic differences due to the different distribution of the alleles of the CYP2D6 gene in different populations. Differences are not only in the incidence of poor metabolizers (PM) of debrisoquone, but also in the enzyme activity within the extensive metabolizer (EM) phenotype. The distribution of the debrisoquine metabolic ratios (MR) is shifted towards higher values among Oriental EMs compared to Caucasian EMs due to the high prevalence of the CYP2D6*10 allele [nomenclature according to Daly et al., 1996] in this population [Wang et al., 1993]. The prevalence of the different alleles of the CYP2D6 gene may be different within different Oriental populations or in particular patient groups. The genotype of 54 patients with diagnosis of major depression according to DSM IV was assessed for the prevalence of the alleles CYP2D6*10, CYP2D6*4, and CYP2D6*8 (the prevalence of which in Chinese is not known). Mutation 2938C→T indicative of CYP2D6*2 (allele L) was also assessed in five patients homozygous for CYP2D6*10 and was found to be absent. Genotyping was performed according to published methods. The CYP2D6*8 and CYP2D6*4 alleles were absent in the present population studied as expected. The CYP2D6*10 allele frequency was 0.6 in the present study, similar to that found among Singaporean Chinese, higher than that found among the Japanese, Koreans, and Chinese living in Sweden (0.51), and lower than that among Taiwanese (0.7) [Wang et al., 1993; Yokota et al., 1993; Lee and Jeyaseelan, 1994; Roh et al., 1996]. Genotyping a healthy Hong Kong Chinese population and testing for other variants of the CYP2D6 gene is in progress. This is the first CYP2D6 genotyping study conducted on a Hong Kong Chinese population. It will contribute to previous data on differences among EMs of different Oriental origins.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.titleGenetic analysis of CYP2D6 locus of Hong Kong Chinese psychiatric patientsen_US
dc.typeArticleen_US
dc.identifier.emailGarciaBarcelo, MM: mmgarcia@hkucc.hku.hken_US
dc.identifier.authorityGarciaBarcelo, MM=rp00445en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-33749091292en_US
dc.identifier.volume81en_US
dc.identifier.issue6en_US
dc.identifier.spage527en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGarciaBarcelo, MM=6701767303en_US
dc.identifier.scopusauthoridChiu, HFK=7401986628en_US
dc.identifier.scopusauthoridWing, YK=21535991900en_US
dc.identifier.scopusauthoridChow, LY=7202533095en_US
dc.identifier.scopusauthoridLam, KL=7403656836en_US
dc.identifier.scopusauthoridWaye, MMY=7006687733en_US

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