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Article: In-Vitro model for evaluation of the effects of supercooling and re-warming on vascular cells

TitleIn-Vitro model for evaluation of the effects of supercooling and re-warming on vascular cells
Authors
Issue Date2006
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00547/index.htm
Citation
International Journal Of Angiology, 2006, v. 14 n. 4, p. 237-241 How to Cite?
AbstractPeripheral vascular disease can be treated by transluminal balloon angioplasty when lesions are favorable. However, the initial technical success rates are complicated by restenosis in which both endothelial cells and smooth muscle cells play a critical role. Cryoplasty, a novel form of treatment combining dilatational forces with the delivery of cold temperature to the vessel wall, has been shown to reduce the rate of restenosis. However, the underlying mechanism and the cellular response to supercooling are still poorly understood. In this study, an in vitro model was developed to examine the effect of supercooling and re-warming on cultured endothelial cell survival. Our results demonstrate that apoptosis of endothelial cells, expressed as the percentage of TUNEL-positive cells, was induced by cooling and increased during the re-warming phase.
Persistent Identifierhttp://hdl.handle.net/10722/172917
ISSN
2015 SCImago Journal Rankings: 0.202
References

 

DC FieldValueLanguage
dc.contributor.authorYiu, WKen_US
dc.contributor.authorAruny, JEen_US
dc.contributor.authorCheng, SWKen_US
dc.contributor.authorSumpio, BEen_US
dc.date.accessioned2012-10-30T06:25:47Z-
dc.date.available2012-10-30T06:25:47Z-
dc.date.issued2006en_US
dc.identifier.citationInternational Journal Of Angiology, 2006, v. 14 n. 4, p. 237-241en_US
dc.identifier.issn1061-1711en_US
dc.identifier.urihttp://hdl.handle.net/10722/172917-
dc.description.abstractPeripheral vascular disease can be treated by transluminal balloon angioplasty when lesions are favorable. However, the initial technical success rates are complicated by restenosis in which both endothelial cells and smooth muscle cells play a critical role. Cryoplasty, a novel form of treatment combining dilatational forces with the delivery of cold temperature to the vessel wall, has been shown to reduce the rate of restenosis. However, the underlying mechanism and the cellular response to supercooling are still poorly understood. In this study, an in vitro model was developed to examine the effect of supercooling and re-warming on cultured endothelial cell survival. Our results demonstrate that apoptosis of endothelial cells, expressed as the percentage of TUNEL-positive cells, was induced by cooling and increased during the re-warming phase.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00547/index.htmen_US
dc.relation.ispartofInternational Journal of Angiologyen_US
dc.titleIn-Vitro model for evaluation of the effects of supercooling and re-warming on vascular cellsen_US
dc.typeArticleen_US
dc.identifier.emailYiu, WK: waikiyiu@hku.hken_US
dc.identifier.emailCheng, SWK: wkcheng@hkucc.hku.hken_US
dc.identifier.authorityYiu, WK=rp00311en_US
dc.identifier.authorityCheng, SWK=rp00374en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00547-005-2055-5en_US
dc.identifier.scopuseid_2-s2.0-33747403475en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33747403475&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume14en_US
dc.identifier.issue4en_US
dc.identifier.spage237en_US
dc.identifier.epage241en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYiu, WK=12763171700en_US
dc.identifier.scopusauthoridAruny, JE=6602191040en_US
dc.identifier.scopusauthoridCheng, SWK=7404684779en_US
dc.identifier.scopusauthoridSumpio, BE=7103201423en_US
dc.identifier.citeulike887107-

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