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Article: The significance of cyclooxygenase-2 expression in human hepatocellular carcinoma

TitleThe significance of cyclooxygenase-2 expression in human hepatocellular carcinoma
Authors
Issue Date2005
PublisherElsevier France, Editions Scientifiques et Medicales. The Journal's web site is located at http://www.elsevier.com/locate/biopha
Citation
Biomedicine And Pharmacotherapy, 2005, v. 59 SUPPL. 2, p. S311-S316 How to Cite?
AbstractHepatocellular carcinoma (HCC) is one of the five most common malignancies in the world and is the second leading cause of death in Hong Kong. Previous studies have shown increased levels of cyclooxygenase-2 (COX-2) in a variety of human malignancies including HCC, suggesting that abnormal COX-2 expression plays an important role in carcinogenesis. In addition, some evidence suggests that selective COX-2 inhibitors suppress the formation of tumors in experimental models. However, there are no data in the literature on using COX-2 as an inhibitor target in HCC. The main objective of this article was to give a brief summary of the recent findings of the role of COX-2 in HCC. We briefly reviewed the significance of COX-2 in varies cancers, and then focused on the recent findings of the significance of COX-2 in HCC. Finally, we further evaluated the possibility of using COX-2 as a therapeutic target in HCC. © 2005 Elsevier SAS. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/172905
ISSN
2015 Impact Factor: 2.326
2015 SCImago Journal Rankings: 0.787
References

 

DC FieldValueLanguage
dc.contributor.authorTang, TCMen_US
dc.contributor.authorPoon, RTPen_US
dc.contributor.authorFan, STen_US
dc.date.accessioned2012-10-30T06:25:43Z-
dc.date.available2012-10-30T06:25:43Z-
dc.date.issued2005en_US
dc.identifier.citationBiomedicine And Pharmacotherapy, 2005, v. 59 SUPPL. 2, p. S311-S316en_US
dc.identifier.issn0753-3322en_US
dc.identifier.urihttp://hdl.handle.net/10722/172905-
dc.description.abstractHepatocellular carcinoma (HCC) is one of the five most common malignancies in the world and is the second leading cause of death in Hong Kong. Previous studies have shown increased levels of cyclooxygenase-2 (COX-2) in a variety of human malignancies including HCC, suggesting that abnormal COX-2 expression plays an important role in carcinogenesis. In addition, some evidence suggests that selective COX-2 inhibitors suppress the formation of tumors in experimental models. However, there are no data in the literature on using COX-2 as an inhibitor target in HCC. The main objective of this article was to give a brief summary of the recent findings of the role of COX-2 in HCC. We briefly reviewed the significance of COX-2 in varies cancers, and then focused on the recent findings of the significance of COX-2 in HCC. Finally, we further evaluated the possibility of using COX-2 as a therapeutic target in HCC. © 2005 Elsevier SAS. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier France, Editions Scientifiques et Medicales. The Journal's web site is located at http://www.elsevier.com/locate/biophaen_US
dc.relation.ispartofBiomedicine and Pharmacotherapyen_US
dc.rightsBiomedicine & Pharmacotherapy. Copyright © Elsevier France, Editions Scientifiques et Medicales.-
dc.subject.meshCarcinoma, Hepatocellular - Enzymology - Pathologyen_US
dc.subject.meshCyclooxygenase 2 - Biosynthesisen_US
dc.subject.meshCyclooxygenase 2 Inhibitors - Therapeutic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Neoplasms - Enzymology - Pathologyen_US
dc.titleThe significance of cyclooxygenase-2 expression in human hepatocellular carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailTungPing Poon, R: poontp@hkucc.hku.hken_US
dc.identifier.emailFan, ST: stfan@hku.hken_US
dc.identifier.authorityTungPing Poon, R=rp00446en_US
dc.identifier.authorityFan, ST=rp00355en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0753-3322(05)80053-8en_US
dc.identifier.pmid16507400-
dc.identifier.scopuseid_2-s2.0-33644531022en_US
dc.identifier.hkuros116882-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33644531022&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume59en_US
dc.identifier.issueSUPPL. 2en_US
dc.identifier.spageS311en_US
dc.identifier.epageS316en_US
dc.publisher.placeFranceen_US
dc.identifier.scopusauthoridChiMan Tang, T=12751846600en_US
dc.identifier.scopusauthoridTungPing Poon, R=7103097223en_US
dc.identifier.scopusauthoridFan, ST=7402678224en_US
dc.customcontrol.immutablejt 2014-05-05-

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