File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Linking Inflammation to Acute Rejection in Small-for-Size Liver Allografts: The Potential Role of Early Macrophage Activation

TitleLinking Inflammation to Acute Rejection in Small-for-Size Liver Allografts: The Potential Role of Early Macrophage Activation
Authors
KeywordsCellular response
Inflammation
Macrophage
Issue Date2004
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AJT
Citation
American Journal Of Transplantation, 2004, v. 4 n. 2, p. 196-209 How to Cite?
AbstractThis study aims to investigate the immunological status of small-for-size liver allografts and possible mechanism that contributes to the accelerated immune response in these allografts. Eight experimental groups were: whole isografts; 40% isografts; whole allografts, no treatment; 40% allografts, no treatment; whole allografts with sodium salicylate intraperitoneal injection, D0-3; 40% allografts with sodium salicylate, D0-3; whole allografts with FK506 intramuscular injection D0-3, and 40% allografts with FK506, D0-3. The 40% allografts survived significantly shorter than whole allografts (p = 0.02). At 72 h after reperfusion, a higher number of macrophages infiltrated into the periportal area of small-for-size allografts than whole allografts. Remarkable up-regulation of interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-10 (IL-10) and interferon-γ (IFN-γ) messenger RNA (mRNA) levels were detected in small-for-size allografts within 24 h after reperfusion. Sodium salicylate administration reduced IL-1β and IFN-γ mRNA in both small-for-size and whole allografts, but it could decrease IL-2 and IL-10 mRNA levels only in small-for-size allografts. In vitro study revealed that CD80, CD86 and CD11b expression on macrophages was augmented after IL-1β stimulation, whereas the up-regulation could be blocked by sodium salicylate. In conclusion, early activation of macrophages as a result of graft injury might play an important role in the accelerated acute rejection process In small-for-size allografts.
Persistent Identifierhttp://hdl.handle.net/10722/172859
ISSN
2015 Impact Factor: 5.669
2015 SCImago Journal Rankings: 2.792
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, ZFen_HK
dc.contributor.authorHo, DWYen_HK
dc.contributor.authorChu, ACYen_HK
dc.contributor.authorWang, YQen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2012-10-30T06:25:22Z-
dc.date.available2012-10-30T06:25:22Z-
dc.date.issued2004en_HK
dc.identifier.citationAmerican Journal Of Transplantation, 2004, v. 4 n. 2, p. 196-209en_HK
dc.identifier.issn1600-6135en_HK
dc.identifier.urihttp://hdl.handle.net/10722/172859-
dc.description.abstractThis study aims to investigate the immunological status of small-for-size liver allografts and possible mechanism that contributes to the accelerated immune response in these allografts. Eight experimental groups were: whole isografts; 40% isografts; whole allografts, no treatment; 40% allografts, no treatment; whole allografts with sodium salicylate intraperitoneal injection, D0-3; 40% allografts with sodium salicylate, D0-3; whole allografts with FK506 intramuscular injection D0-3, and 40% allografts with FK506, D0-3. The 40% allografts survived significantly shorter than whole allografts (p = 0.02). At 72 h after reperfusion, a higher number of macrophages infiltrated into the periportal area of small-for-size allografts than whole allografts. Remarkable up-regulation of interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-10 (IL-10) and interferon-γ (IFN-γ) messenger RNA (mRNA) levels were detected in small-for-size allografts within 24 h after reperfusion. Sodium salicylate administration reduced IL-1β and IFN-γ mRNA in both small-for-size and whole allografts, but it could decrease IL-2 and IL-10 mRNA levels only in small-for-size allografts. In vitro study revealed that CD80, CD86 and CD11b expression on macrophages was augmented after IL-1β stimulation, whereas the up-regulation could be blocked by sodium salicylate. In conclusion, early activation of macrophages as a result of graft injury might play an important role in the accelerated acute rejection process In small-for-size allografts.en_HK
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AJTen_HK
dc.relation.ispartofAmerican Journal of Transplantationen_HK
dc.subjectCellular responseen_HK
dc.subjectInflammationen_HK
dc.subjectMacrophageen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshGraft Rejection - Immunology - Pathologyen_US
dc.subject.meshGraft Survival - Drug Effects - Immunologyen_US
dc.subject.meshInflammation - Immunology - Pathologyen_US
dc.subject.meshLiver - Anatomy & Histologyen_US
dc.subject.meshLiver Transplantation - Immunology - Pathologyen_US
dc.subject.meshMacrophage Activation - Immunologyen_US
dc.subject.meshMaleen_US
dc.subject.meshRna, Messenger - Geneticsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Lewen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshTransplantation, Homologousen_US
dc.subject.meshTransplantation, Isogeneicen_US
dc.titleLinking Inflammation to Acute Rejection in Small-for-Size Liver Allografts: The Potential Role of Early Macrophage Activationen_HK
dc.typeArticleen_HK
dc.identifier.emailChu, ACY: bcccy@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityChu, ACY=rp00505en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1600-6143.2003.00313.xen_HK
dc.identifier.pmid14974940-
dc.identifier.scopuseid_2-s2.0-1342304224en_HK
dc.identifier.hkuros85952-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1342304224&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume4en_HK
dc.identifier.issue2en_HK
dc.identifier.spage196en_HK
dc.identifier.epage209en_HK
dc.identifier.isiWOS:000188644100008-
dc.publisher.placeDenmarken_HK
dc.identifier.scopusauthoridYang, ZF=14018809600en_HK
dc.identifier.scopusauthoridHo, DWY=7402971906en_HK
dc.identifier.scopusauthoridChu, ACY=24343085700en_HK
dc.identifier.scopusauthoridWang, YQ=23981317400en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats