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Article: Distribution of surface-exposed antigenic glycolipids in recent clinical isolates of Mycobacterium tuberculosis

TitleDistribution of surface-exposed antigenic glycolipids in recent clinical isolates of Mycobacterium tuberculosis
Authors
Issue Date1997
PublisherElsevier France, Editions Scientifiques et Medicales. The Journal's web site is located at http://www.elsevier.com/locate/resmic
Citation
Research In Microbiology, 1997, v. 148 n. 5, p. 405-412 How to Cite?
AbstractThe distribution of surface-exposed antigenic glycolipids in seven recent clinical isolates of Mycobacterium tuberculosis was established. Thin- layer and liquid chromatographies revealed a uniformity in the glycolipid pattern. Chemical analysis of the individual glycolipids of a selected strain enabled the identification of glycolipids of serological interest in all the other clinical isolates. Phenolic glycolipid-Tb1 (PGL-Tb1) was lacking in all strains, but appreciable amounts of a partially deglycosylated version (PGL- Tb1D) were present in the seven isolates. Diacyltrehaloses (DATs) were detected in all strains, showing themselves to be major glycolipids. Lipooligosaccharides (LOS-II) were present in the seven strains studied though only in trace amounts. These results shed new light on the open debate on the distribution of these interesting glycolipids in typical clinical isolates of M. tuberculosis. In the search for a serological test for tuberculosis, and in accordance with our observations, we believe that PGL- Tb1 and LOS-II should not be the target molecules for serology and that it is worthwhile to continue investigating the value of DATa as antigens. We also believe that it would be of interest to undertake research to assess the usefulness of PGL-Tb1D as an antigen.
Persistent Identifierhttp://hdl.handle.net/10722/172842
ISSN
2015 Impact Factor: 2.154
2015 SCImago Journal Rankings: 1.070
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMuñoz, Men_US
dc.contributor.authorLuquin, Men_US
dc.contributor.authorGarcíaBarcelo, Men_US
dc.contributor.authorJulián, Een_US
dc.contributor.authorAusina, Ven_US
dc.contributor.authorLanéelle, MAen_US
dc.date.accessioned2012-10-30T06:25:14Z-
dc.date.available2012-10-30T06:25:14Z-
dc.date.issued1997en_US
dc.identifier.citationResearch In Microbiology, 1997, v. 148 n. 5, p. 405-412en_US
dc.identifier.issn0923-2508en_US
dc.identifier.urihttp://hdl.handle.net/10722/172842-
dc.description.abstractThe distribution of surface-exposed antigenic glycolipids in seven recent clinical isolates of Mycobacterium tuberculosis was established. Thin- layer and liquid chromatographies revealed a uniformity in the glycolipid pattern. Chemical analysis of the individual glycolipids of a selected strain enabled the identification of glycolipids of serological interest in all the other clinical isolates. Phenolic glycolipid-Tb1 (PGL-Tb1) was lacking in all strains, but appreciable amounts of a partially deglycosylated version (PGL- Tb1D) were present in the seven isolates. Diacyltrehaloses (DATs) were detected in all strains, showing themselves to be major glycolipids. Lipooligosaccharides (LOS-II) were present in the seven strains studied though only in trace amounts. These results shed new light on the open debate on the distribution of these interesting glycolipids in typical clinical isolates of M. tuberculosis. In the search for a serological test for tuberculosis, and in accordance with our observations, we believe that PGL- Tb1 and LOS-II should not be the target molecules for serology and that it is worthwhile to continue investigating the value of DATa as antigens. We also believe that it would be of interest to undertake research to assess the usefulness of PGL-Tb1D as an antigen.en_US
dc.languageengen_US
dc.publisherElsevier France, Editions Scientifiques et Medicales. The Journal's web site is located at http://www.elsevier.com/locate/resmicen_US
dc.relation.ispartofResearch in Microbiologyen_US
dc.subject.meshAntigens, Bacterial - Analysisen_US
dc.subject.meshGlycolipids - Analysisen_US
dc.subject.meshLipopolysaccharides - Analysisen_US
dc.subject.meshMycobacterium Tuberculosis - Chemistry - Immunologyen_US
dc.titleDistribution of surface-exposed antigenic glycolipids in recent clinical isolates of Mycobacterium tuberculosisen_US
dc.typeArticleen_US
dc.identifier.emailGarcíaBarcelo, M: mmgarcia@hkucc.hku.hken_US
dc.identifier.authorityGarcíaBarcelo, M=rp00445en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0923-2508(97)83871-5en_US
dc.identifier.pmid9765819-
dc.identifier.scopuseid_2-s2.0-0343742586en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0343742586&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume148en_US
dc.identifier.issue5en_US
dc.identifier.spage405en_US
dc.identifier.epage412en_US
dc.identifier.isiWOS:A1997XL28700004-
dc.publisher.placeFranceen_US
dc.identifier.scopusauthoridMuñoz, M=36920520700en_US
dc.identifier.scopusauthoridLuquin, M=7006736171en_US
dc.identifier.scopusauthoridGarcíaBarcelo, M=6701767303en_US
dc.identifier.scopusauthoridJulián, E=6701695698en_US
dc.identifier.scopusauthoridAusina, V=35394134800en_US
dc.identifier.scopusauthoridLanéelle, MA=7004226145en_US

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