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Article: mRNA of placental origin is readily detectable in maternal plasma

TitlemRNA of placental origin is readily detectable in maternal plasma
Authors
Issue Date2003
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 2003, v. 100 n. 8, p. 4748-4753 How to Cite?
AbstractThe discovery of circulating fetal nucleic acid in maternal plasma has opened up new possibilities for noninvasive prenatal diagnosis. Thus far, a gender- and polymorphism-independent fetal-specific target that can be used for prenatal screening and monitoring in all pregnant women has not been reported. In addition, the origin of such circulating nucleic acid has remained unclear. Here we provide direct evidence that the placenta is an important source of fetal nucleic acid release into maternal plasma by demonstrating that mRNA transcripts from placenta-expressed genes are readily detectable in maternal plasma. The surprising stability of such placental mRNA species in maternal plasma and their rapid clearance after delivery demonstrate that such circulating mRNA molecules are practical markers for clinical use. The measurement of such plasma mRNA markers has provided a gender-independent approach for noninvasive prenatal gene expression profiling and has opened up numerous research and diagnostic possibilities.
Persistent Identifierhttp://hdl.handle.net/10722/172826
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, EKOen_US
dc.contributor.authorTsui, NBYen_US
dc.contributor.authorLau, TKen_US
dc.contributor.authorLeung, TNen_US
dc.contributor.authorChiu, RWKen_US
dc.contributor.authorPanesar, NSen_US
dc.contributor.authorLit, LCWen_US
dc.contributor.authorChan, KWen_US
dc.contributor.authorLo, YMDen_US
dc.date.accessioned2012-10-30T06:25:09Z-
dc.date.available2012-10-30T06:25:09Z-
dc.date.issued2003en_US
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2003, v. 100 n. 8, p. 4748-4753en_US
dc.identifier.issn0027-8424en_US
dc.identifier.urihttp://hdl.handle.net/10722/172826-
dc.description.abstractThe discovery of circulating fetal nucleic acid in maternal plasma has opened up new possibilities for noninvasive prenatal diagnosis. Thus far, a gender- and polymorphism-independent fetal-specific target that can be used for prenatal screening and monitoring in all pregnant women has not been reported. In addition, the origin of such circulating nucleic acid has remained unclear. Here we provide direct evidence that the placenta is an important source of fetal nucleic acid release into maternal plasma by demonstrating that mRNA transcripts from placenta-expressed genes are readily detectable in maternal plasma. The surprising stability of such placental mRNA species in maternal plasma and their rapid clearance after delivery demonstrate that such circulating mRNA molecules are practical markers for clinical use. The measurement of such plasma mRNA markers has provided a gender-independent approach for noninvasive prenatal gene expression profiling and has opened up numerous research and diagnostic possibilities.en_US
dc.languageengen_US
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_US
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshBiological Transport, Activeen_US
dc.subject.meshDna Primers - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetus - Metabolismen_US
dc.subject.meshGene Expression Profilingen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshHumansen_US
dc.subject.meshMaternal-Fetal Exchange - Geneticsen_US
dc.subject.meshPlacenta - Metabolismen_US
dc.subject.meshPlacental Lactogen - Geneticsen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPrenatal Diagnosisen_US
dc.subject.meshRna Stabilityen_US
dc.subject.meshRna, Messenger - Blood - Genetics - Metabolismen_US
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_US
dc.titlemRNA of placental origin is readily detectable in maternal plasmaen_US
dc.typeArticleen_US
dc.identifier.emailNg, EKO: ngko@hku.hken_US
dc.identifier.authorityNg, EKO=rp01364en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1073/pnas.0637450100en_US
dc.identifier.pmid12644709-
dc.identifier.scopuseid_2-s2.0-0037447089en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037447089&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume100en_US
dc.identifier.issue8en_US
dc.identifier.spage4748en_US
dc.identifier.epage4753en_US
dc.identifier.isiWOS:000182306100074-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridNg, EKO=21135553700en_US
dc.identifier.scopusauthoridTsui, NBY=6602401748en_US
dc.identifier.scopusauthoridLau, TK=24491963900en_US
dc.identifier.scopusauthoridLeung, TN=7202110927en_US
dc.identifier.scopusauthoridChiu, RWK=7103038413en_US
dc.identifier.scopusauthoridPanesar, NS=7005824593en_US
dc.identifier.scopusauthoridLit, LCW=6602660237en_US
dc.identifier.scopusauthoridChan, KW=36915718400en_US
dc.identifier.scopusauthoridLo, YMD=7401935391en_US

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