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Article: Overexpression of Cdc25b, an androgen receptor coactivator, in prostate cancer

TitleOverexpression of Cdc25b, an androgen receptor coactivator, in prostate cancer
Authors
Issue Date2003
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/onc
Citation
Oncogene, 2003, v. 22 n. 5, p. 734-739 How to Cite?
AbstractCdc25B is a dual-specific phosphatase that mediates cell cycle progression by activating the cyclin-dependent kinases. It has been shown to possess oncogenic potential. To elucidate its potential contribution to human prostate cancer development, the expression profile of Cdc25B protein in human patients was analysed by immunohistocytochemistry. Cdc25B is frequently overexpressed in human prostate cancer tissues (29 of 30; 97%). In addition, the overexpression is more profound in the tumors of high combined Gleason scores and in late stages. Subsequently, we demonstrated that Cdc25B acts as a coactivator for AR in a hormone-dependent manner in the prostate cancer cell line, LNCaP. This coactivator function, surprisingly, is independent of its cell cycle functions. Cdc25B, on the other hand, directly interacts with AR as evidenced in GST-pull down and mammalian two-hybrid assays. In addition, it is also able to enhance AR-mediated transcription in synergy with other coactivators, including CREB-binding protein (CBP) and p300/CBP associated factor. Therefore, upregulation of Cdc25B in human prostate cancer and its interplay with AR may contribute to prostate cancer development.
Persistent Identifierhttp://hdl.handle.net/10722/172825
ISSN
2015 Impact Factor: 7.932
2015 SCImago Journal Rankings: 4.047
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNgan, ESWen_US
dc.contributor.authorHashimoto, Yen_US
dc.contributor.authorMa, ZQen_US
dc.contributor.authorTsai, MJen_US
dc.contributor.authorTsai, SYen_US
dc.date.accessioned2012-10-30T06:25:08Z-
dc.date.available2012-10-30T06:25:08Z-
dc.date.issued2003en_US
dc.identifier.citationOncogene, 2003, v. 22 n. 5, p. 734-739en_US
dc.identifier.issn0950-9232en_US
dc.identifier.urihttp://hdl.handle.net/10722/172825-
dc.description.abstractCdc25B is a dual-specific phosphatase that mediates cell cycle progression by activating the cyclin-dependent kinases. It has been shown to possess oncogenic potential. To elucidate its potential contribution to human prostate cancer development, the expression profile of Cdc25B protein in human patients was analysed by immunohistocytochemistry. Cdc25B is frequently overexpressed in human prostate cancer tissues (29 of 30; 97%). In addition, the overexpression is more profound in the tumors of high combined Gleason scores and in late stages. Subsequently, we demonstrated that Cdc25B acts as a coactivator for AR in a hormone-dependent manner in the prostate cancer cell line, LNCaP. This coactivator function, surprisingly, is independent of its cell cycle functions. Cdc25B, on the other hand, directly interacts with AR as evidenced in GST-pull down and mammalian two-hybrid assays. In addition, it is also able to enhance AR-mediated transcription in synergy with other coactivators, including CREB-binding protein (CBP) and p300/CBP associated factor. Therefore, upregulation of Cdc25B in human prostate cancer and its interplay with AR may contribute to prostate cancer development.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/oncen_US
dc.relation.ispartofOncogeneen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCell Cycle Proteins - Biosynthesis - Genetics - Metabolismen_US
dc.subject.meshCell Transformation, Neoplastic - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMutationen_US
dc.subject.meshProstatic Neoplasms - Genetics - Metabolismen_US
dc.subject.meshReceptors, Androgen - Genetics - Metabolismen_US
dc.subject.meshTranscription, Geneticen_US
dc.subject.meshUp-Regulationen_US
dc.subject.meshCdc25 Phosphatases - Biosynthesis - Genetics - Metabolismen_US
dc.titleOverexpression of Cdc25b, an androgen receptor coactivator, in prostate canceren_US
dc.typeArticleen_US
dc.identifier.emailNgan, ESW: engan@hkucc.hku.hken_US
dc.identifier.authorityNgan, ESW=rp00422en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/sj.onc.1206121en_US
dc.identifier.pmid12569365-
dc.identifier.scopuseid_2-s2.0-0037421958en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037421958&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume22en_US
dc.identifier.issue5en_US
dc.identifier.spage734en_US
dc.identifier.epage739en_US
dc.identifier.isiWOS:000180642100010-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridNgan, ESW=22234827500en_US
dc.identifier.scopusauthoridHashimoto, Y=35447645500en_US
dc.identifier.scopusauthoridMa, ZQ=7403600106en_US
dc.identifier.scopusauthoridTsai, MJ=7403548953en_US
dc.identifier.scopusauthoridTsai, SY=7403478781en_US

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