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Article: Comparison of acute cellular rejection between living donor liver transplantation and cadaveric liver transplantation

TitleComparison of acute cellular rejection between living donor liver transplantation and cadaveric liver transplantation
Authors
Issue Date2001
Publisher中華醫學會. The Journal's web site is located at http://zhyx.chinajournal.net.cn/
Citation
Zhonghua Yi Xue Za Zhi, 2001, v. 81 n. 18, p. 1092-1094 How to Cite?
AbstractOBJECTIVE: To compare the incidence and severity of acute cwellular rejection (ACR) between living donor liver transplantation (LDLT) and cadaveric liver transplantation (CLT). METHODS: 51 patients underwent LDLT among which 30 received the liver of blood-related donors, and 65 patients underwent CLT. Clinical data, such as the cold ischemic time of liver graft, use of immunosuppressive agents, ACR rate, response to steroid therapy, HLA matching between donor and recipient, and survival rates of liver graft and patients were collected and analyzed. RESULTS: The graft survival rate, patient survival rate, ACR rate, ACR multiple incidence rate, and no response rate to steroid therapy in CLT and LDLT groups were 72% vs 78%, 77% vs. 78%, 48% vs. 41%, 20% vs. 10%, and 11% vs. 4% (P > 0.05). The difference of ACR rates between CLT and living blood-related donor liver transplantation was statistically insignificant. There was no significant difference in number of HLA allele mismatching between patients with ACR and those without ACR. The combined immunosuppression therapy rely mainly on FK506 use reduced the occurrence of ACR (P < 0.05). CONCLUSION: There is no marked difference in incidence of ACR between LDLT and CLT. ACR in liver transplantation is correlated to neither HLA matching between donors and recipients nor to cold ischemic time of the liver graft. FK506 avoids ACR better than cyclosporin2 A.
Persistent Identifierhttp://hdl.handle.net/10722/172800
ISSN
2015 SCImago Journal Rankings: 0.134

 

DC FieldValueLanguage
dc.contributor.authorFan, Sen_US
dc.contributor.authorZhang, Zen_US
dc.date.accessioned2012-10-30T06:25:00Z-
dc.date.available2012-10-30T06:25:00Z-
dc.date.issued2001en_US
dc.identifier.citationZhonghua Yi Xue Za Zhi, 2001, v. 81 n. 18, p. 1092-1094en_US
dc.identifier.issn0376-2491en_US
dc.identifier.urihttp://hdl.handle.net/10722/172800-
dc.description.abstractOBJECTIVE: To compare the incidence and severity of acute cwellular rejection (ACR) between living donor liver transplantation (LDLT) and cadaveric liver transplantation (CLT). METHODS: 51 patients underwent LDLT among which 30 received the liver of blood-related donors, and 65 patients underwent CLT. Clinical data, such as the cold ischemic time of liver graft, use of immunosuppressive agents, ACR rate, response to steroid therapy, HLA matching between donor and recipient, and survival rates of liver graft and patients were collected and analyzed. RESULTS: The graft survival rate, patient survival rate, ACR rate, ACR multiple incidence rate, and no response rate to steroid therapy in CLT and LDLT groups were 72% vs 78%, 77% vs. 78%, 48% vs. 41%, 20% vs. 10%, and 11% vs. 4% (P > 0.05). The difference of ACR rates between CLT and living blood-related donor liver transplantation was statistically insignificant. There was no significant difference in number of HLA allele mismatching between patients with ACR and those without ACR. The combined immunosuppression therapy rely mainly on FK506 use reduced the occurrence of ACR (P < 0.05). CONCLUSION: There is no marked difference in incidence of ACR between LDLT and CLT. ACR in liver transplantation is correlated to neither HLA matching between donors and recipients nor to cold ischemic time of the liver graft. FK506 avoids ACR better than cyclosporin2 A.en_US
dc.languageengen_US
dc.publisher中華醫學會. The Journal's web site is located at http://zhyx.chinajournal.net.cn/en_US
dc.relation.ispartofZhonghua yi xue za zhien_US
dc.subject.meshAdulten_US
dc.subject.meshCadaveren_US
dc.subject.meshFemaleen_US
dc.subject.meshGraft Rejection - Epidemiology - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Transplantation - Immunology - Mortalityen_US
dc.subject.meshLiving Donorsen_US
dc.subject.meshMaleen_US
dc.subject.meshTissue Donorsen_US
dc.titleComparison of acute cellular rejection between living donor liver transplantation and cadaveric liver transplantationen_US
dc.typeArticleen_US
dc.identifier.emailFan, S: stfan@hku.hken_US
dc.identifier.authorityFan, S=rp00355en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid11766604-
dc.identifier.scopuseid_2-s2.0-0035949963en_US
dc.identifier.volume81en_US
dc.identifier.issue18en_US
dc.identifier.spage1092en_US
dc.identifier.epage1094en_US
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridFan, S=7402678224en_US
dc.identifier.scopusauthoridZhang, Z=8574700400en_US

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