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Article: International sharing of split liver grafts in Asia: Initial exprience

TitleInternational sharing of split liver grafts in Asia: Initial exprience
Authors
Issue Date2000
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CTR
Citation
Clinical Transplantation, 2000, v. 14 n. 4 I, p. 355-359 How to Cite?
AbstractThe donor shortage problem is particularly serious in Asia and has markedly limited progress in liver transplantation. The increasing demand has, in fact, made it necessary to resort to living donor liver transplantation in both pediatric and adult recipients. Nevertheless, expanding the use of split liver allografts is yet another option to increase the supply. This has a wide potential application on a regional level because most liver transplant programs are still small and may have limited resources in terms of being able to do two transplants in one sitting. The first experience of overseas sharing of split liver grafts in Asia took place in January 1999. The graft was from a 35-yr-old donor from Kaohsiung, Taiwan, who sustained irreversible brain damage in a vehicular accident and had optimal conditions for multiorgan donation. The liver was split ex vivo and the left lateral segment was given to a 3-yr-old girl with biliary atresia at the Chang Gung Memorial Hospital. The extended right lobe split graft was transported to Hong Kong and transplanted into a 51-yr-old male patient with end-stage hepatitis C cirrhosis who was then in a state of acute failure with hepatorenal syndrome. Graft function was excellent in both recipients and the patient from Taiwan was discharged without any complications. Unfortunately, the Hong Kong recipient developed a cerebrovascular accident and required a reoperation for bile leakage from the cut surface of the liver in the early postoperative period. He has made a steady recovery since then; graft function has remained good and his kidneys have recovered. Both patients are currently alive and well 11 months post-transplant. This initial experience of overseas sharing of split liver grafts in Asia demonstrates its feasibility. It has a potentially wide applicability and could lead to the establishment of a formal organ-sharing network in the region. Established competence and mutual trust among the participating liver transplant teams would be essential in perpetuating such a graft-multiplying strategy on an organized basis.
Persistent Identifierhttp://hdl.handle.net/10722/172770
ISSN
2015 Impact Factor: 1.844
2015 SCImago Journal Rankings: 0.821
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDe Villa, VHen_US
dc.contributor.authorChen, CLen_US
dc.contributor.authorChen, YSen_US
dc.contributor.authorWang, CCen_US
dc.contributor.authorWang, SHen_US
dc.contributor.authorChiang, YCen_US
dc.contributor.authorCheng, YFen_US
dc.contributor.authorJawan, Ben_US
dc.contributor.authorCheung, HKen_US
dc.contributor.authorFan, STen_US
dc.contributor.authorLo, CMen_US
dc.date.accessioned2012-10-30T06:24:50Z-
dc.date.available2012-10-30T06:24:50Z-
dc.date.issued2000en_US
dc.identifier.citationClinical Transplantation, 2000, v. 14 n. 4 I, p. 355-359en_US
dc.identifier.issn0902-0063en_US
dc.identifier.urihttp://hdl.handle.net/10722/172770-
dc.description.abstractThe donor shortage problem is particularly serious in Asia and has markedly limited progress in liver transplantation. The increasing demand has, in fact, made it necessary to resort to living donor liver transplantation in both pediatric and adult recipients. Nevertheless, expanding the use of split liver allografts is yet another option to increase the supply. This has a wide potential application on a regional level because most liver transplant programs are still small and may have limited resources in terms of being able to do two transplants in one sitting. The first experience of overseas sharing of split liver grafts in Asia took place in January 1999. The graft was from a 35-yr-old donor from Kaohsiung, Taiwan, who sustained irreversible brain damage in a vehicular accident and had optimal conditions for multiorgan donation. The liver was split ex vivo and the left lateral segment was given to a 3-yr-old girl with biliary atresia at the Chang Gung Memorial Hospital. The extended right lobe split graft was transported to Hong Kong and transplanted into a 51-yr-old male patient with end-stage hepatitis C cirrhosis who was then in a state of acute failure with hepatorenal syndrome. Graft function was excellent in both recipients and the patient from Taiwan was discharged without any complications. Unfortunately, the Hong Kong recipient developed a cerebrovascular accident and required a reoperation for bile leakage from the cut surface of the liver in the early postoperative period. He has made a steady recovery since then; graft function has remained good and his kidneys have recovered. Both patients are currently alive and well 11 months post-transplant. This initial experience of overseas sharing of split liver grafts in Asia demonstrates its feasibility. It has a potentially wide applicability and could lead to the establishment of a formal organ-sharing network in the region. Established competence and mutual trust among the participating liver transplant teams would be essential in perpetuating such a graft-multiplying strategy on an organized basis.en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CTRen_US
dc.relation.ispartofClinical Transplantationen_US
dc.subject.meshAdulten_US
dc.subject.meshAsiaen_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInternational Cooperationen_US
dc.subject.meshLiver Transplantationen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshTissue And Organ Procurement - Methodsen_US
dc.titleInternational sharing of split liver grafts in Asia: Initial exprienceen_US
dc.typeArticleen_US
dc.identifier.emailFan, ST: stfan@hku.hken_US
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_US
dc.identifier.authorityFan, ST=rp00355en_US
dc.identifier.authorityLo, CM=rp00412en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1034/j.1399-0012.2000.140413.xen_US
dc.identifier.pmid10945208-
dc.identifier.scopuseid_2-s2.0-0033899133en_US
dc.identifier.hkuros56197-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033899133&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume14en_US
dc.identifier.issue4 Ien_US
dc.identifier.spage355en_US
dc.identifier.epage359en_US
dc.identifier.isiWOS:000088472600013-
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridDe Villa, VH=7004295971en_US
dc.identifier.scopusauthoridChen, CL=25949456200en_US
dc.identifier.scopusauthoridChen, YS=7601440086en_US
dc.identifier.scopusauthoridWang, CC=9735308100en_US
dc.identifier.scopusauthoridWang, SH=7410348460en_US
dc.identifier.scopusauthoridChiang, YC=7201593365en_US
dc.identifier.scopusauthoridCheng, YF=7404915788en_US
dc.identifier.scopusauthoridJawan, B=7006147821en_US
dc.identifier.scopusauthoridCheung, HK=7201839339en_US
dc.identifier.scopusauthoridFan, ST=7402678224en_US
dc.identifier.scopusauthoridLo, CM=7401771672en_US

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