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Article: Radiation hybrid mapping of human cytosolic malate dehydrogenase (hcMDH) to the short arm of chromosome 2

TitleRadiation hybrid mapping of human cytosolic malate dehydrogenase (hcMDH) to the short arm of chromosome 2
Authors
Issue Date1999
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0740-7750
Citation
Somatic Cell And Molecular Genetics, 1999, v. 25 n. 2, p. 109-113 How to Cite?
AbstractCompartmentalization of human cytosolic malate dehydrogenase, hcMDH, together with its isozyme partner-mitochondrial form, hmMDH, plays an important role in the aerobic metabolism of the malate-aspartate shuttle and the citric acid cycle. However, they share few structural homology at the molecular level. The pseudogenes of mMDH has been reported in mice but hcMDH has no pseudogenes as shown by Southern blot analysis. A single band only was detected for the EcoRI digestion with 9.4 kb long of human genomic DNA and HindIII cutting with 2.8kb long. hcMDH gene was mapped to chromosome 2 by somatic cell hybrid analysis and further localised to 268.72cR from the top telomere of Chromosome 2 (near 2p15) by radiation hybrid mapping. The genes falling into this region may be related to dilated cardiomyopathy (DCM), several types of cancers and immunoregulation mechanism of cancers.
Persistent Identifierhttp://hdl.handle.net/10722/172762
ISSN
2000 Impact Factor: 0.884
2005 SCImago Journal Rankings: 1.061
References

 

DC FieldValueLanguage
dc.contributor.authorYee Lo, ASen_US
dc.contributor.authorLiew, CTen_US
dc.contributor.authorWan Law, PTen_US
dc.contributor.authorGarciaBarceló, Men_US
dc.contributor.authorTsui, SKWen_US
dc.contributor.authorFung, KPen_US
dc.contributor.authorYu Lee, Cen_US
dc.contributor.authorYee Waye, MMen_US
dc.date.accessioned2012-10-30T06:24:47Z-
dc.date.available2012-10-30T06:24:47Z-
dc.date.issued1999en_US
dc.identifier.citationSomatic Cell And Molecular Genetics, 1999, v. 25 n. 2, p. 109-113en_US
dc.identifier.issn0740-7750en_US
dc.identifier.urihttp://hdl.handle.net/10722/172762-
dc.description.abstractCompartmentalization of human cytosolic malate dehydrogenase, hcMDH, together with its isozyme partner-mitochondrial form, hmMDH, plays an important role in the aerobic metabolism of the malate-aspartate shuttle and the citric acid cycle. However, they share few structural homology at the molecular level. The pseudogenes of mMDH has been reported in mice but hcMDH has no pseudogenes as shown by Southern blot analysis. A single band only was detected for the EcoRI digestion with 9.4 kb long of human genomic DNA and HindIII cutting with 2.8kb long. hcMDH gene was mapped to chromosome 2 by somatic cell hybrid analysis and further localised to 268.72cR from the top telomere of Chromosome 2 (near 2p15) by radiation hybrid mapping. The genes falling into this region may be related to dilated cardiomyopathy (DCM), several types of cancers and immunoregulation mechanism of cancers.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0740-7750en_US
dc.relation.ispartofSomatic Cell and Molecular Geneticsen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshChromosomes, Human, Pair 2 - Geneticsen_US
dc.subject.meshCytosol - Enzymologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMalate Dehydrogenase - Geneticsen_US
dc.subject.meshRadiation Hybrid Mappingen_US
dc.titleRadiation hybrid mapping of human cytosolic malate dehydrogenase (hcMDH) to the short arm of chromosome 2en_US
dc.typeArticleen_US
dc.identifier.emailGarciaBarceló, M: mmgarcia@hkucc.hku.hken_US
dc.identifier.authorityGarciaBarceló, M=rp00445en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1023/B:SCAM.0000007146.36319.ceen_US
dc.identifier.pmid11225055-
dc.identifier.scopuseid_2-s2.0-0033283135en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033283135&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume25en_US
dc.identifier.issue2en_US
dc.identifier.spage109en_US
dc.identifier.epage113en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYee Lo, AS=23053611300en_US
dc.identifier.scopusauthoridLiew, CT=35809476000en_US
dc.identifier.scopusauthoridWan Law, PT=23053148100en_US
dc.identifier.scopusauthoridGarciaBarceló, M=6701767303en_US
dc.identifier.scopusauthoridTsui, SKW=7004961364en_US
dc.identifier.scopusauthoridFung, KP=7202934739en_US
dc.identifier.scopusauthoridYu Lee, C=23053628300en_US
dc.identifier.scopusauthoridYee Waye, MM=7006687733en_US

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