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Article: Management options and survival in malignant melanoma of the sinonasal mucosa

TitleManagement options and survival in malignant melanoma of the sinonasal mucosa
Authors
Issue Date1999
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.laryngoscope.com/
Citation
Laryngoscope, 1999, v. 109 n. 2 I, p. 208-211 How to Cite?
AbstractObjective/Hypothesis: To determine whether surgery combined with radiotherapy confers any survival benefit on radical local excision alone in the management of mucosal malignant melanoma of the nose and sinuses. Study Design: Retrospective review. Methods: From a cohort of 72 patients treated between 1963 and 1996 within a single unit, complete data were available for 58 individuals who were examined to determine whether there was any significant statistical difference in local control and/or survival between those receiving surgery and those receiving combined surgery and radiotherapy. Results: There were 30 men and 28 women. Their ages ranged from 39 to 90 years (mean, 64 y). Twenty-nine patients underwent surgery alone; 23 patients underwent surgery and radiotherapy; 6 patients received surgery and chemotherapy; and 3 patients received surgery, chemotherapy, and radiotherapy. Primary surgery included lateral rhinotomy (42 cases), maxillectomy (8 cases [orbital clearance in 3 cases]), craniofacial resection (3 cases), total rhinectomy (3 cases), and endoscopic clearance (2 cases). Survival ranged from 1 to 228 months with rapid patient loss due to local (and/or systemic) disease during the first 36 months, irrespective of the treatment modality. Overall 5-year actuarial survival was 28%, and overall 10-year actuarial survival 20%, with a median survival of 21 months. There was no statistical difference in local control or survival between patients receiving surgery alone and those receiving surgery and radiotherapy, irrespective of whether this treatment was given in the early part of the series (i.e., before 1983) or thereafter. The addition of chemotherapy had no impact on survival, nor did the site of the tumor, the surgical procedure, the presence of lymph node metastases or the age of the patient. Conclusion: In this large cohort of sinonasal melanoma, overall survival was poor and did not appear to be improved by the addition of radiotherapy.
Persistent Identifierhttp://hdl.handle.net/10722/172761
ISSN
2015 Impact Factor: 2.272
2015 SCImago Journal Rankings: 1.342
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLund, VJen_US
dc.contributor.authorHoward, DJen_US
dc.contributor.authorHarding, Len_US
dc.contributor.authorWei, WIen_US
dc.date.accessioned2012-10-30T06:24:46Z-
dc.date.available2012-10-30T06:24:46Z-
dc.date.issued1999en_US
dc.identifier.citationLaryngoscope, 1999, v. 109 n. 2 I, p. 208-211en_US
dc.identifier.issn0023-852Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/172761-
dc.description.abstractObjective/Hypothesis: To determine whether surgery combined with radiotherapy confers any survival benefit on radical local excision alone in the management of mucosal malignant melanoma of the nose and sinuses. Study Design: Retrospective review. Methods: From a cohort of 72 patients treated between 1963 and 1996 within a single unit, complete data were available for 58 individuals who were examined to determine whether there was any significant statistical difference in local control and/or survival between those receiving surgery and those receiving combined surgery and radiotherapy. Results: There were 30 men and 28 women. Their ages ranged from 39 to 90 years (mean, 64 y). Twenty-nine patients underwent surgery alone; 23 patients underwent surgery and radiotherapy; 6 patients received surgery and chemotherapy; and 3 patients received surgery, chemotherapy, and radiotherapy. Primary surgery included lateral rhinotomy (42 cases), maxillectomy (8 cases [orbital clearance in 3 cases]), craniofacial resection (3 cases), total rhinectomy (3 cases), and endoscopic clearance (2 cases). Survival ranged from 1 to 228 months with rapid patient loss due to local (and/or systemic) disease during the first 36 months, irrespective of the treatment modality. Overall 5-year actuarial survival was 28%, and overall 10-year actuarial survival 20%, with a median survival of 21 months. There was no statistical difference in local control or survival between patients receiving surgery alone and those receiving surgery and radiotherapy, irrespective of whether this treatment was given in the early part of the series (i.e., before 1983) or thereafter. The addition of chemotherapy had no impact on survival, nor did the site of the tumor, the surgical procedure, the presence of lymph node metastases or the age of the patient. Conclusion: In this large cohort of sinonasal melanoma, overall survival was poor and did not appear to be improved by the addition of radiotherapy.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.laryngoscope.com/en_US
dc.relation.ispartofLaryngoscopeen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshCombined Modality Therapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMelanoma - Mortality - Therapyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNasal Mucosa - Radiation Effects - Surgeryen_US
dc.subject.meshNose Neoplasms - Mortality - Therapyen_US
dc.subject.meshParanasal Sinus Neoplasms - Mortality - Therapyen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshSurvival Rateen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleManagement options and survival in malignant melanoma of the sinonasal mucosaen_US
dc.typeArticleen_US
dc.identifier.emailWei, WI: hrmswwi@hku.hken_US
dc.identifier.authorityWei, WI=rp00323en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00005537-199902000-00007en_US
dc.identifier.pmid10890767-
dc.identifier.scopuseid_2-s2.0-0033011120en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033011120&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume109en_US
dc.identifier.issue2 Ien_US
dc.identifier.spage208en_US
dc.identifier.epage211en_US
dc.identifier.isiWOS:000078432500007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLund, VJ=7102840344en_US
dc.identifier.scopusauthoridHoward, DJ=7202305361en_US
dc.identifier.scopusauthoridHarding, L=7102215316en_US
dc.identifier.scopusauthoridWei, WI=7403321552en_US

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