Article: Schizophrenia and hypocalcaemia: Variable phenotype of deletion at chromosome 22q11

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Publisher Website: 10.1046/j.1440-1614.1999.00617.x
Scopus: eid_2-s2.0-0032829232
PMID: 10545003

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Title	Schizophrenia and hypocalcaemia: Variable phenotype of deletion at chromosome 22q11
Authors	Chow, LY1 2 GarciaBarcelo, M1 2 Wing, YK1 2 Waye, MMY1 2
Issue Date	1999
Publisher	Informa Healthcare. The Journal's web site is located at http://informahealthcare.com/anp
Citation	Australian And New Zealand Journal Of Psychiatry, 1999, v. 33 n. 5, p. 760-762 [How to Cite?] DOI: http://dx.doi.org/10.1046/j.1440-1614.1999.00617.x
Abstract	Objective: The aim of this paper is to report the diagnosis of velo-cardio-facial syndrome (VCFS) in a patient presenting with schizophrenia and hypocalcaemia. Screening of deletion 22q11 in patients with schizophrenia is discussed. Clinical picture: We report a schizophrenic patient presenting with hypocalcaemia as the only feature of VCFS. Deletion 22q11 was confirmed by fluorescent in situ hybridisation (FISH). Treatment: The patient was treated with haloperidol 3 mg/day with resolution of psychotic symptoms. Outcome: The patient harboured some residual psychotic symptoms probably related to her irregular compliance. Conclusions: The wide range of phenotypic variability of VCFS makes screening of 22q11 deletion in schizophrenia difficult. It is proposed that screening of 22q11 deletion in schizophrenia should be selectively targeted only at patients with specific features of VCFS highly predictive of the presence of 22q11 deletion.
ISSN	0004-8674 2011 Impact Factor: 2.929 2011 SCImago Journal Rankings: 0.112
DOI	http://dx.doi.org/10.1046/j.1440-1614.1999.00617.x
References	References in Scopus

DC Field	Value
dc.contributor.author	Chow, LY
dc.contributor.author	GarciaBarcelo, M
dc.contributor.author	Wing, YK
dc.contributor.author	Waye, MMY
dc.date.accessioned	2012-10-30T06:24:45Z
dc.date.available	2012-10-30T06:24:45Z
dc.date.issued	1999
dc.description.abstract	Objective: The aim of this paper is to report the diagnosis of velo-cardio-facial syndrome (VCFS) in a patient presenting with schizophrenia and hypocalcaemia. Screening of deletion 22q11 in patients with schizophrenia is discussed. Clinical picture: We report a schizophrenic patient presenting with hypocalcaemia as the only feature of VCFS. Deletion 22q11 was confirmed by fluorescent in situ hybridisation (FISH). Treatment: The patient was treated with haloperidol 3 mg/day with resolution of psychotic symptoms. Outcome: The patient harboured some residual psychotic symptoms probably related to her irregular compliance. Conclusions: The wide range of phenotypic variability of VCFS makes screening of 22q11 deletion in schizophrenia difficult. It is proposed that screening of 22q11 deletion in schizophrenia should be selectively targeted only at patients with specific features of VCFS highly predictive of the presence of 22q11 deletion.
dc.description.nature	Link_to_subscribed_fulltext
dc.identifier.citation	Australian And New Zealand Journal Of Psychiatry, 1999, v. 33 n. 5, p. 760-762 [How to Cite?] DOI: http://dx.doi.org/10.1046/j.1440-1614.1999.00617.x
dc.identifier.doi	http://dx.doi.org/10.1046/j.1440-1614.1999.00617.x
dc.identifier.epage	762
dc.identifier.issn	0004-8674 2011 Impact Factor: 2.929 2011 SCImago Journal Rankings: 0.112
dc.identifier.issue	5
dc.identifier.pmid	10545003
dc.identifier.scopus	eid_2-s2.0-0032829232
dc.identifier.spage	760
dc.identifier.uri	http://hdl.handle.net/10722/172757
dc.identifier.volume	33
dc.language	eng
dc.publisher	Informa Healthcare. The Journal's web site is located at http://informahealthcare.com/anp
dc.publisher.place	United Kingdom
dc.relation.ispartof	Australian and New Zealand Journal of Psychiatry
dc.relation.references	References in Scopus
dc.subject.mesh	Adult
dc.subject.mesh	Chromosome Deletion
dc.subject.mesh	Chromosomes, Human, Pair 22 - Genetics
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Hypocalcemia - Complications
dc.subject.mesh	Phenotype
dc.subject.mesh	Schizophrenia - Complications
dc.subject.mesh	Syndrome
dc.title	Schizophrenia and hypocalcaemia: Variable phenotype of deletion at chromosome 22q11
dc.type	Article

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Author Affiliations

Prince of Wales Hospital Hong Kong
Chinese University of Hong Kong

Article: Schizophrenia and hypocalcaemia: Variable phenotype of deletion at chromosome 22q11

The HKU Scholars Hub has contact details for these author(s).