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Article: Schizophrenia and hypocalcaemia: Variable phenotype of deletion at chromosome 22q11
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TitleSchizophrenia and hypocalcaemia: Variable phenotype of deletion at chromosome 22q11
 
AuthorsChow, LY1 2
GarciaBarcelo, M1 2
Wing, YK1 2
Waye, MMY1 2
 
Issue Date1999
 
PublisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/anp
 
CitationAustralian And New Zealand Journal Of Psychiatry, 1999, v. 33 n. 5, p. 760-762 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1440-1614.1999.00617.x
 
AbstractObjective: The aim of this paper is to report the diagnosis of velo-cardio-facial syndrome (VCFS) in a patient presenting with schizophrenia and hypocalcaemia. Screening of deletion 22q11 in patients with schizophrenia is discussed. Clinical picture: We report a schizophrenic patient presenting with hypocalcaemia as the only feature of VCFS. Deletion 22q11 was confirmed by fluorescent in situ hybridisation (FISH). Treatment: The patient was treated with haloperidol 3 mg/day with resolution of psychotic symptoms. Outcome: The patient harboured some residual psychotic symptoms probably related to her irregular compliance. Conclusions: The wide range of phenotypic variability of VCFS makes screening of 22q11 deletion in schizophrenia difficult. It is proposed that screening of 22q11 deletion in schizophrenia should be selectively targeted only at patients with specific features of VCFS highly predictive of the presence of 22q11 deletion.
 
ISSN0004-8674
2013 Impact Factor: 3.765
 
DOIhttp://dx.doi.org/10.1046/j.1440-1614.1999.00617.x
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChow, LY
 
dc.contributor.authorGarciaBarcelo, M
 
dc.contributor.authorWing, YK
 
dc.contributor.authorWaye, MMY
 
dc.date.accessioned2012-10-30T06:24:45Z
 
dc.date.available2012-10-30T06:24:45Z
 
dc.date.issued1999
 
dc.description.abstractObjective: The aim of this paper is to report the diagnosis of velo-cardio-facial syndrome (VCFS) in a patient presenting with schizophrenia and hypocalcaemia. Screening of deletion 22q11 in patients with schizophrenia is discussed. Clinical picture: We report a schizophrenic patient presenting with hypocalcaemia as the only feature of VCFS. Deletion 22q11 was confirmed by fluorescent in situ hybridisation (FISH). Treatment: The patient was treated with haloperidol 3 mg/day with resolution of psychotic symptoms. Outcome: The patient harboured some residual psychotic symptoms probably related to her irregular compliance. Conclusions: The wide range of phenotypic variability of VCFS makes screening of 22q11 deletion in schizophrenia difficult. It is proposed that screening of 22q11 deletion in schizophrenia should be selectively targeted only at patients with specific features of VCFS highly predictive of the presence of 22q11 deletion.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationAustralian And New Zealand Journal Of Psychiatry, 1999, v. 33 n. 5, p. 760-762 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1440-1614.1999.00617.x
 
dc.identifier.doihttp://dx.doi.org/10.1046/j.1440-1614.1999.00617.x
 
dc.identifier.epage762
 
dc.identifier.issn0004-8674
2013 Impact Factor: 3.765
 
dc.identifier.issue5
 
dc.identifier.pmid10545003
 
dc.identifier.scopuseid_2-s2.0-0032829232
 
dc.identifier.spage760
 
dc.identifier.urihttp://hdl.handle.net/10722/172757
 
dc.identifier.volume33
 
dc.languageeng
 
dc.publisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/anp
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofAustralian and New Zealand Journal of Psychiatry
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshChromosome Deletion
 
dc.subject.meshChromosomes, Human, Pair 22 - Genetics
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshHypocalcemia - Complications
 
dc.subject.meshPhenotype
 
dc.subject.meshSchizophrenia - Complications
 
dc.subject.meshSyndrome
 
dc.titleSchizophrenia and hypocalcaemia: Variable phenotype of deletion at chromosome 22q11
 
dc.typeArticle
 
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<contributor.author>GarciaBarcelo, M</contributor.author>
<contributor.author>Wing, YK</contributor.author>
<contributor.author>Waye, MMY</contributor.author>
<date.accessioned>2012-10-30T06:24:45Z</date.accessioned>
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<subject.mesh>Adult</subject.mesh>
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<subject.mesh>Female</subject.mesh>
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Author Affiliations
  1. Prince of Wales Hospital Hong Kong
  2. Chinese University of Hong Kong