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Article: Characterization of a new EBV-associated nasopharyngeal carcinoma cell line

TitleCharacterization of a new EBV-associated nasopharyngeal carcinoma cell line
Authors
Issue Date1998
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 1998, v. 101 n. 2, p. 83-88 How to Cite?
AbstractOnly a few reports exist of cytogenetic studies in nasophoryngeal carcinoma (NPC), probably because of the technical limitations of culturing solid tumors. We established a cell line (cell-666) that was derived from an NPC xenograft growing in athymic nude mice. Epstein-Barr virus (EBV) infection is one of the important etiologic factors of NPC. This cell line has been shown to have the consistent presence of EBV by Epstein-Barr virus encoded RNAs (EBER) in situ hybridization. Furthermore, aberrant methylation of 5'CpG island of p16 gene was detected. Thus, this cell line represents a valuable model for the study of NPC tumorigenecity. The karyotype of this newly established cell line is: 45,X,del(X)(q24), - 5der(5)(5pter→5q31::5q13→5q31::5p12→5pter),der(6;?)(q10;p10),add(7)(p22),+ 9, del(11)(q13),add(12)(p13),-14,-18,-21, +2mar. Fluorescence in situ hybridization analyses were performed using whole chromosome painting probes of chromosomes 5, 6, 11, and 12.
Persistent Identifierhttp://hdl.handle.net/10722/172749
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHui, ABYen_US
dc.contributor.authorCheung, STen_US
dc.contributor.authorFong, Yen_US
dc.contributor.authorLo, KWen_US
dc.contributor.authorHuang, DPen_US
dc.date.accessioned2012-10-30T06:24:41Z-
dc.date.available2012-10-30T06:24:41Z-
dc.date.issued1998en_US
dc.identifier.citationCancer Genetics And Cytogenetics, 1998, v. 101 n. 2, p. 83-88en_US
dc.identifier.issn0165-4608en_US
dc.identifier.urihttp://hdl.handle.net/10722/172749-
dc.description.abstractOnly a few reports exist of cytogenetic studies in nasophoryngeal carcinoma (NPC), probably because of the technical limitations of culturing solid tumors. We established a cell line (cell-666) that was derived from an NPC xenograft growing in athymic nude mice. Epstein-Barr virus (EBV) infection is one of the important etiologic factors of NPC. This cell line has been shown to have the consistent presence of EBV by Epstein-Barr virus encoded RNAs (EBER) in situ hybridization. Furthermore, aberrant methylation of 5'CpG island of p16 gene was detected. Thus, this cell line represents a valuable model for the study of NPC tumorigenecity. The karyotype of this newly established cell line is: 45,X,del(X)(q24), - 5der(5)(5pter→5q31::5q13→5q31::5p12→5pter),der(6;?)(q10;p10),add(7)(p22),+ 9, del(11)(q13),add(12)(p13),-14,-18,-21, +2mar. Fluorescence in situ hybridization analyses were performed using whole chromosome painting probes of chromosomes 5, 6, 11, and 12.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_US
dc.relation.ispartofCancer Genetics and Cytogeneticsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshHerpesviridae Infections - Geneticsen_US
dc.subject.meshHerpesvirus 4, Human - Isolation & Purificationen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Nudeen_US
dc.subject.meshNasopharyngeal Neoplasms - Genetics - Virologyen_US
dc.subject.meshNeoplasm Transplantationen_US
dc.subject.meshRna, Viral - Analysisen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.subject.meshTumor Virus Infections - Geneticsen_US
dc.titleCharacterization of a new EBV-associated nasopharyngeal carcinoma cell lineen_US
dc.typeArticleen_US
dc.identifier.emailCheung, ST: stcheung@hkucc.hku.hken_US
dc.identifier.authorityCheung, ST=rp00457en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(97)00231-8en_US
dc.identifier.pmid9494607-
dc.identifier.scopuseid_2-s2.0-0032032305en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032032305&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume101en_US
dc.identifier.issue2en_US
dc.identifier.spage83en_US
dc.identifier.epage88en_US
dc.identifier.isiWOS:000072177700001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHui, ABY=7102453683en_US
dc.identifier.scopusauthoridCheung, ST=7202473497en_US
dc.identifier.scopusauthoridFong, Y=7103055113en_US
dc.identifier.scopusauthoridLo, KW=7402101603en_US
dc.identifier.scopusauthoridHuang, DP=7403891486en_US

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