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Article: A region of homozygous deletion on chromosome 9p21-22 in primary nasopharyngeal carcinoma

TitleA region of homozygous deletion on chromosome 9p21-22 in primary nasopharyngeal carcinoma
Authors
Issue Date1994
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 1994, v. 54 n. 15, p. 4003-4006 How to Cite?
AbstractUsing 21 microsatellite polymorphic markers spanning both p and q arms, we have performed detailed deletion mapping on chromosome 9 in 18 primary nasopharyngeal carcinomas. All 18 tumors were informative at multiple loci. Eleven of the 18 cases (61%) demonstrated allelic deletion of chromosome 9. Among these 11, 6 cases are likely to be tumors with monosomy of chromosome 9. The other 5 cases demonstrated partial deletion by showing multiple areas of allelic loss. In one of the 5 cases, a homozygous deletion region was identified which includes D9S126, D9S171, and IFNA loci at 9p21-22, situated between loci D9S161 (9p21) and D9S162 (9p21-22). The presence of a homozygous deletion strongly suggests the presence of tumor suppressor gene(s) involved in the tumorigenesis of nasopharyngeal carcinoma. The same region has been reported to include some potential tumor suppressor gene loci in other cancers. This is the first reported finding of frequent genetic loss observed on chromosome 9 in nasopharyngeal carcinomas in addition to allelic loss on chromosome 3p at specific regions. Our results suggest that tumorigenesis and progression of nasopharyngeal carcinomas, like other solid tumors, involves multiple genetic changes associated with the inactivation of tumor suppressor genes.
Persistent Identifierhttp://hdl.handle.net/10722/172702
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHuang, DPen_US
dc.contributor.authorLo, KWen_US
dc.contributor.authorVan Hasselt, CAen_US
dc.contributor.authorWoo, JKSen_US
dc.contributor.authorChoi, PHKen_US
dc.contributor.authorLeung, SFen_US
dc.contributor.authorCheung, STen_US
dc.contributor.authorCairns, Pen_US
dc.contributor.authorSidransky, Den_US
dc.contributor.authorLee, JCKen_US
dc.date.accessioned2012-10-30T06:24:23Z-
dc.date.available2012-10-30T06:24:23Z-
dc.date.issued1994en_US
dc.identifier.citationCancer Research, 1994, v. 54 n. 15, p. 4003-4006en_US
dc.identifier.issn0008-5472en_US
dc.identifier.urihttp://hdl.handle.net/10722/172702-
dc.description.abstractUsing 21 microsatellite polymorphic markers spanning both p and q arms, we have performed detailed deletion mapping on chromosome 9 in 18 primary nasopharyngeal carcinomas. All 18 tumors were informative at multiple loci. Eleven of the 18 cases (61%) demonstrated allelic deletion of chromosome 9. Among these 11, 6 cases are likely to be tumors with monosomy of chromosome 9. The other 5 cases demonstrated partial deletion by showing multiple areas of allelic loss. In one of the 5 cases, a homozygous deletion region was identified which includes D9S126, D9S171, and IFNA loci at 9p21-22, situated between loci D9S161 (9p21) and D9S162 (9p21-22). The presence of a homozygous deletion strongly suggests the presence of tumor suppressor gene(s) involved in the tumorigenesis of nasopharyngeal carcinoma. The same region has been reported to include some potential tumor suppressor gene loci in other cancers. This is the first reported finding of frequent genetic loss observed on chromosome 9 in nasopharyngeal carcinomas in addition to allelic loss on chromosome 3p at specific regions. Our results suggest that tumorigenesis and progression of nasopharyngeal carcinomas, like other solid tumors, involves multiple genetic changes associated with the inactivation of tumor suppressor genes.en_US
dc.languageengen_US
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_US
dc.relation.ispartofCancer Researchen_US
dc.subject.meshAllelesen_US
dc.subject.meshCarcinoma - Geneticsen_US
dc.subject.meshChromosome Deletionen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshChromosomes, Human, Pair 9en_US
dc.subject.meshHomozygoteen_US
dc.subject.meshHumansen_US
dc.subject.meshNasopharyngeal Neoplasms - Geneticsen_US
dc.titleA region of homozygous deletion on chromosome 9p21-22 in primary nasopharyngeal carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailCheung, ST: stcheung@hkucc.hku.hken_US
dc.identifier.authorityCheung, ST=rp00457en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8033130-
dc.identifier.scopuseid_2-s2.0-0027966039en_US
dc.identifier.volume54en_US
dc.identifier.issue15en_US
dc.identifier.spage4003en_US
dc.identifier.epage4006en_US
dc.identifier.isiWOS:A1994NZ24600013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHuang, DP=7403891486en_US
dc.identifier.scopusauthoridLo, KW=7402101603en_US
dc.identifier.scopusauthoridVan Hasselt, CA=7103394173en_US
dc.identifier.scopusauthoridWoo, JKS=27268094700en_US
dc.identifier.scopusauthoridChoi, PHK=7102909162en_US
dc.identifier.scopusauthoridLeung, SF=7202044876en_US
dc.identifier.scopusauthoridCheung, ST=7202473497en_US
dc.identifier.scopusauthoridCairns, P=7005812364en_US
dc.identifier.scopusauthoridSidransky, D=7102109701en_US
dc.identifier.scopusauthoridLee, JCK=7601456915en_US

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