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Article: Risk factors for liver transplantation across the ABO barrier

TitleRisk factors for liver transplantation across the ABO barrier
Authors
Issue Date1994
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.transplantjournal.com
Citation
Transplantation, 1994, v. 58 n. 5, p. 543-547 How to Cite?
AbstractA retrospective study was performed to identify risk factors affecting the fate of liver allografts transplanted across the ABO barrier. Over a 5-year period, 30 patients received 31 emergency OLTs with ABO-incompatible allografts. One-year graft and patient survival rates were 37.1% and 48.4%, respectively. This group was compared with 199 ABO-compatible OLTs performed under similar emergency conditions. Significantly higher incidence of rejection, hepatic artery thrombosis, and biliary stricture were found in ABO-incompatible grafts. The graft or patient survival of patients with O blood group or fulminant hepatic failure was not affected by ABO incompatibility. In contrast, the 1-year survival of recipients with non-O blood group was only 13.3% and the 1-year survival of those undergoing retransplantation was only 27.7% after ABO-incompatible OLT. A multivariate analysis using the Cox proportional hazard model identified non-O blood group (relative risk 3.43) and retransplantation (relative risk 2.46) as the most important risk factors for patients survival after ABO-incompatible OLT. We conclude that the use of ABO-incompatible grafts is justified in emergency cases when no other donor is available, but should be proscribed in patients with non-O blood group. The value of ABO-incompatible grafts in retransplantation is questionable and requires further investigation.
Persistent Identifierhttp://hdl.handle.net/10722/172698
ISSN
2015 Impact Factor: 3.69
2015 SCImago Journal Rankings: 1.699
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLo, CMen_US
dc.contributor.authorShaked, Aen_US
dc.contributor.authorBusuttil, RWen_US
dc.date.accessioned2012-10-30T06:24:22Z-
dc.date.available2012-10-30T06:24:22Z-
dc.date.issued1994en_US
dc.identifier.citationTransplantation, 1994, v. 58 n. 5, p. 543-547en_US
dc.identifier.issn0041-1337en_US
dc.identifier.urihttp://hdl.handle.net/10722/172698-
dc.description.abstractA retrospective study was performed to identify risk factors affecting the fate of liver allografts transplanted across the ABO barrier. Over a 5-year period, 30 patients received 31 emergency OLTs with ABO-incompatible allografts. One-year graft and patient survival rates were 37.1% and 48.4%, respectively. This group was compared with 199 ABO-compatible OLTs performed under similar emergency conditions. Significantly higher incidence of rejection, hepatic artery thrombosis, and biliary stricture were found in ABO-incompatible grafts. The graft or patient survival of patients with O blood group or fulminant hepatic failure was not affected by ABO incompatibility. In contrast, the 1-year survival of recipients with non-O blood group was only 13.3% and the 1-year survival of those undergoing retransplantation was only 27.7% after ABO-incompatible OLT. A multivariate analysis using the Cox proportional hazard model identified non-O blood group (relative risk 3.43) and retransplantation (relative risk 2.46) as the most important risk factors for patients survival after ABO-incompatible OLT. We conclude that the use of ABO-incompatible grafts is justified in emergency cases when no other donor is available, but should be proscribed in patients with non-O blood group. The value of ABO-incompatible grafts in retransplantation is questionable and requires further investigation.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.transplantjournal.comen_US
dc.relation.ispartofTransplantationen_US
dc.subject.meshAbo Blood-Group Systemen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshBiliary Tract Diseases - Etiologyen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGraft Rejection - Blooden_US
dc.subject.meshGraft Survival - Immunologyen_US
dc.subject.meshHepatic Arteryen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Transplantation - Adverse Effects - Immunology - Mortalityen_US
dc.subject.meshMaleen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSurvival Analysisen_US
dc.subject.meshThrombosis - Etiologyen_US
dc.titleRisk factors for liver transplantation across the ABO barrieren_US
dc.typeArticleen_US
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_US
dc.identifier.authorityLo, CM=rp00412en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00007890-199409150-00003-
dc.identifier.pmid8091480-
dc.identifier.scopuseid_2-s2.0-0027941461en_US
dc.identifier.volume58en_US
dc.identifier.issue5en_US
dc.identifier.spage543en_US
dc.identifier.epage547en_US
dc.identifier.isiWOS:A1994PG20200003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLo, CM=7401771672en_US
dc.identifier.scopusauthoridShaked, A=7007027236en_US
dc.identifier.scopusauthoridBusuttil, RW=7101995142en_US

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