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- Publisher Website: 10.1097/00007890-199409150-00003
- Scopus: eid_2-s2.0-0027941461
- PMID: 8091480
- WOS: WOS:A1994PG20200003
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Article: Risk factors for liver transplantation across the ABO barrier
Title | Risk factors for liver transplantation across the ABO barrier |
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Authors | |
Issue Date | 1994 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.transplantjournal.com |
Citation | Transplantation, 1994, v. 58 n. 5, p. 543-547 How to Cite? |
Abstract | A retrospective study was performed to identify risk factors affecting the fate of liver allografts transplanted across the ABO barrier. Over a 5-year period, 30 patients received 31 emergency OLTs with ABO-incompatible allografts. One-year graft and patient survival rates were 37.1% and 48.4%, respectively. This group was compared with 199 ABO-compatible OLTs performed under similar emergency conditions. Significantly higher incidence of rejection, hepatic artery thrombosis, and biliary stricture were found in ABO-incompatible grafts. The graft or patient survival of patients with O blood group or fulminant hepatic failure was not affected by ABO incompatibility. In contrast, the 1-year survival of recipients with non-O blood group was only 13.3% and the 1-year survival of those undergoing retransplantation was only 27.7% after ABO-incompatible OLT. A multivariate analysis using the Cox proportional hazard model identified non-O blood group (relative risk 3.43) and retransplantation (relative risk 2.46) as the most important risk factors for patients survival after ABO-incompatible OLT. We conclude that the use of ABO-incompatible grafts is justified in emergency cases when no other donor is available, but should be proscribed in patients with non-O blood group. The value of ABO-incompatible grafts in retransplantation is questionable and requires further investigation. |
Persistent Identifier | http://hdl.handle.net/10722/172698 |
ISSN | 2023 Impact Factor: 5.3 2023 SCImago Journal Rankings: 1.371 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lo, CM | en_US |
dc.contributor.author | Shaked, A | en_US |
dc.contributor.author | Busuttil, RW | en_US |
dc.date.accessioned | 2012-10-30T06:24:22Z | - |
dc.date.available | 2012-10-30T06:24:22Z | - |
dc.date.issued | 1994 | en_US |
dc.identifier.citation | Transplantation, 1994, v. 58 n. 5, p. 543-547 | en_US |
dc.identifier.issn | 0041-1337 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/172698 | - |
dc.description.abstract | A retrospective study was performed to identify risk factors affecting the fate of liver allografts transplanted across the ABO barrier. Over a 5-year period, 30 patients received 31 emergency OLTs with ABO-incompatible allografts. One-year graft and patient survival rates were 37.1% and 48.4%, respectively. This group was compared with 199 ABO-compatible OLTs performed under similar emergency conditions. Significantly higher incidence of rejection, hepatic artery thrombosis, and biliary stricture were found in ABO-incompatible grafts. The graft or patient survival of patients with O blood group or fulminant hepatic failure was not affected by ABO incompatibility. In contrast, the 1-year survival of recipients with non-O blood group was only 13.3% and the 1-year survival of those undergoing retransplantation was only 27.7% after ABO-incompatible OLT. A multivariate analysis using the Cox proportional hazard model identified non-O blood group (relative risk 3.43) and retransplantation (relative risk 2.46) as the most important risk factors for patients survival after ABO-incompatible OLT. We conclude that the use of ABO-incompatible grafts is justified in emergency cases when no other donor is available, but should be proscribed in patients with non-O blood group. The value of ABO-incompatible grafts in retransplantation is questionable and requires further investigation. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.transplantjournal.com | en_US |
dc.relation.ispartof | Transplantation | en_US |
dc.subject.mesh | Abo Blood-Group System | en_US |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Analysis Of Variance | en_US |
dc.subject.mesh | Biliary Tract Diseases - Etiology | en_US |
dc.subject.mesh | Child | en_US |
dc.subject.mesh | Child, Preschool | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Follow-Up Studies | en_US |
dc.subject.mesh | Graft Rejection - Blood | en_US |
dc.subject.mesh | Graft Survival - Immunology | en_US |
dc.subject.mesh | Hepatic Artery | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Liver Transplantation - Adverse Effects - Immunology - Mortality | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Retrospective Studies | en_US |
dc.subject.mesh | Risk Factors | en_US |
dc.subject.mesh | Survival Analysis | en_US |
dc.subject.mesh | Thrombosis - Etiology | en_US |
dc.title | Risk factors for liver transplantation across the ABO barrier | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lo, CM: chungmlo@hkucc.hku.hk | en_US |
dc.identifier.authority | Lo, CM=rp00412 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1097/00007890-199409150-00003 | - |
dc.identifier.pmid | 8091480 | - |
dc.identifier.scopus | eid_2-s2.0-0027941461 | en_US |
dc.identifier.volume | 58 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.spage | 543 | en_US |
dc.identifier.epage | 547 | en_US |
dc.identifier.isi | WOS:A1994PG20200003 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Lo, CM=7401771672 | en_US |
dc.identifier.scopusauthorid | Shaked, A=7007027236 | en_US |
dc.identifier.scopusauthorid | Busuttil, RW=7101995142 | en_US |
dc.identifier.issnl | 0041-1337 | - |