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Article: Regional chemotherapy for recurrent squamous head and neck cancers through a saphenous vein interposition graft

TitleRegional chemotherapy for recurrent squamous head and neck cancers through a saphenous vein interposition graft
Authors
Issue Date1993
PublisherAmerican Medical Association. The Journal's web site is located at http://www.archoto.com
Citation
Archives Of Otolaryngology - Head And Neck Surgery, 1993, v. 119 n. 6, p. 608-611 How to Cite?
AbstractRegional chemotherapy for head and neck cancers is effective, but the intra-arterial catheter is not without problems. We interposed a segment of saphenous vein within the carotid system to administer chemotherapeutic agents percutaneously via the arterialized venous segment. From 1983 to 1990, saphenous vein interposition graft was performed after radiotherapy in 24 patients with persistent or recurrent squamous head and neck cancers, which were also considered unresectable. There was no operative mortality. Two patients developed thrombosed vein graft; another two had wound infection; and one patient had a neck hematoma. Cisplatin was administered percutaneously every week via the saphenous vein graft. The response rate was 64% (complete response, 23%; partial response, 41%), and the 5-year actuarial survival rate was 31%. The 1-year survival rates for patients with complete, partial, and no response were 80%, 33%, and 13%, respectively. Saphenous vein interposition graft is a safe and convenient way of delivering intra-arterial chemotherapy, and it provides significant palliation for patients with recurrent nonresectable squamous head and neck cancers after radiotherapy.
Persistent Identifierhttp://hdl.handle.net/10722/172689
ISSN
2014 Impact Factor: 2.327
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, CMen_US
dc.contributor.authorLam, LKen_US
dc.contributor.authorWei, WIen_US
dc.contributor.authorChoi, TKen_US
dc.contributor.authorLam, KHen_US
dc.date.accessioned2012-10-30T06:24:17Z-
dc.date.available2012-10-30T06:24:17Z-
dc.date.issued1993en_US
dc.identifier.citationArchives Of Otolaryngology - Head And Neck Surgery, 1993, v. 119 n. 6, p. 608-611en_US
dc.identifier.issn0886-4470en_US
dc.identifier.urihttp://hdl.handle.net/10722/172689-
dc.description.abstractRegional chemotherapy for head and neck cancers is effective, but the intra-arterial catheter is not without problems. We interposed a segment of saphenous vein within the carotid system to administer chemotherapeutic agents percutaneously via the arterialized venous segment. From 1983 to 1990, saphenous vein interposition graft was performed after radiotherapy in 24 patients with persistent or recurrent squamous head and neck cancers, which were also considered unresectable. There was no operative mortality. Two patients developed thrombosed vein graft; another two had wound infection; and one patient had a neck hematoma. Cisplatin was administered percutaneously every week via the saphenous vein graft. The response rate was 64% (complete response, 23%; partial response, 41%), and the 5-year actuarial survival rate was 31%. The 1-year survival rates for patients with complete, partial, and no response were 80%, 33%, and 13%, respectively. Saphenous vein interposition graft is a safe and convenient way of delivering intra-arterial chemotherapy, and it provides significant palliation for patients with recurrent nonresectable squamous head and neck cancers after radiotherapy.en_US
dc.languageengen_US
dc.publisherAmerican Medical Association. The Journal's web site is located at http://www.archoto.comen_US
dc.relation.ispartofArchives of Otolaryngology - Head and Neck Surgeryen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAnastomosis, Surgicalen_US
dc.subject.meshCarcinoma, Squamous Cell - Complications - Drug Therapy - Mortalityen_US
dc.subject.meshCarotid Artery, Common - Surgeryen_US
dc.subject.meshCarotid Artery, External - Surgeryen_US
dc.subject.meshChemotherapy, Cancer, Regional Perfusion - Methodsen_US
dc.subject.meshCisplatin - Administration & Dosage - Adverse Effectsen_US
dc.subject.meshCombined Modality Therapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHead And Neck Neoplasms - Complications - Drug Therapy - Mortalityen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Recurrence, Local - Complications - Drug Therapy - Mortalityen_US
dc.subject.meshRemission Inductionen_US
dc.subject.meshSaphenous Vein - Transplantationen_US
dc.titleRegional chemotherapy for recurrent squamous head and neck cancers through a saphenous vein interposition graften_US
dc.typeArticleen_US
dc.identifier.emailWei, WI: hrmswwi@hku.hken_US
dc.identifier.authorityWei, WI=rp00323en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8499089-
dc.identifier.scopuseid_2-s2.0-0027225387en_US
dc.identifier.volume119en_US
dc.identifier.issue6en_US
dc.identifier.spage608en_US
dc.identifier.epage611en_US
dc.identifier.isiWOS:A1993LF78300002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHo, CM=7404652540en_US
dc.identifier.scopusauthoridLam, LK=7201984637en_US
dc.identifier.scopusauthoridWei, WI=7403321552en_US
dc.identifier.scopusauthoridChoi, TK=7202770029en_US
dc.identifier.scopusauthoridLam, KH=7403657342en_US

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