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Article: Detection of subclinical nasopharyngeal carcinoma by fibreoptic endoscopy and multiple biopsy

TitleDetection of subclinical nasopharyngeal carcinoma by fibreoptic endoscopy and multiple biopsy
Authors
Issue Date1990
PublisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
Citation
Lancet, 1990, v. 335 n. 8686, p. 371-374 How to Cite?
AbstractOf 6054 people who had high titres of antibodies against the viral capsid antigen of Epstein-Barr virus but no symptoms or signs of nasopharyngeal carcinoma as assessed by conventional methods, 130 were randomly recruited and examined by fibreoptic endoscopy and biopsy of several sites of the nasopharynx. 7 cases of nasopharyngeal carcinoma were detected. The tumours were largely confined to the pharyngeal recess, which suggests that it is the area of the nasopharynx most prone to the development of the tumour. Tumour was found in both recesses in 1 subject, who also had evidence of transition from severe epithelial dysplasia to carcinoma in a sample from the left roof, which suggests that the disease was multifocal in origin. This study showed that endoscopy and biopsy of several sites of the nasopharynx are more effective than the conventional approach in the detection of subclinical nasopharyngeal carcinoma among seropositive individuals at high risk of the disorder.
Persistent Identifierhttp://hdl.handle.net/10722/172620
ISSN
2015 Impact Factor: 44.002
2015 SCImago Journal Rankings: 14.638
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSham, JSTen_US
dc.contributor.authorWei, WIen_US
dc.contributor.authorYongSheng, Zen_US
dc.contributor.authorChoy, Den_US
dc.contributor.authorYanQin, Gen_US
dc.contributor.authorYan, Len_US
dc.contributor.authorZhiXiong, Len_US
dc.contributor.authorNg, MHen_US
dc.date.accessioned2012-10-30T06:23:48Z-
dc.date.available2012-10-30T06:23:48Z-
dc.date.issued1990en_US
dc.identifier.citationLancet, 1990, v. 335 n. 8686, p. 371-374en_US
dc.identifier.issn0140-6736en_US
dc.identifier.urihttp://hdl.handle.net/10722/172620-
dc.description.abstractOf 6054 people who had high titres of antibodies against the viral capsid antigen of Epstein-Barr virus but no symptoms or signs of nasopharyngeal carcinoma as assessed by conventional methods, 130 were randomly recruited and examined by fibreoptic endoscopy and biopsy of several sites of the nasopharynx. 7 cases of nasopharyngeal carcinoma were detected. The tumours were largely confined to the pharyngeal recess, which suggests that it is the area of the nasopharynx most prone to the development of the tumour. Tumour was found in both recesses in 1 subject, who also had evidence of transition from severe epithelial dysplasia to carcinoma in a sample from the left roof, which suggests that the disease was multifocal in origin. This study showed that endoscopy and biopsy of several sites of the nasopharynx are more effective than the conventional approach in the detection of subclinical nasopharyngeal carcinoma among seropositive individuals at high risk of the disorder.en_US
dc.languageengen_US
dc.publisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lanceten_US
dc.relation.ispartofLanceten_US
dc.subject.meshAdulten_US
dc.subject.meshAntibodies, Viral - Analysisen_US
dc.subject.meshBiopsy - Methodsen_US
dc.subject.meshCapsid - Immunologyen_US
dc.subject.meshCarcinoma - Epidemiology - Immunology - Pathologyen_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshEndoscopyen_US
dc.subject.meshEvaluation Studies As Topicen_US
dc.subject.meshFemaleen_US
dc.subject.meshHerpesvirus 4, Human - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin A - Analysisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNasal Mucosa - Pathologyen_US
dc.subject.meshNasopharyngeal Neoplasms - Epidemiology - Immunology - Pathologyen_US
dc.subject.meshNasopharynx - Pathologyen_US
dc.titleDetection of subclinical nasopharyngeal carcinoma by fibreoptic endoscopy and multiple biopsyen_US
dc.typeArticleen_US
dc.identifier.emailWei, WI: hrmswwi@hku.hken_US
dc.identifier.authorityWei, WI=rp00323en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0140-6736(90)90206-Ken_US
dc.identifier.pmid1968116-
dc.identifier.scopuseid_2-s2.0-0025122409en_US
dc.identifier.volume335en_US
dc.identifier.issue8686en_US
dc.identifier.spage371en_US
dc.identifier.epage374en_US
dc.identifier.isiWOS:A1990CN98800003-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSham, JST=7101655565en_US
dc.identifier.scopusauthoridWei, WI=7403321552en_US
dc.identifier.scopusauthoridYongSheng, Z=6506399602en_US
dc.identifier.scopusauthoridChoy, D=7102939127en_US
dc.identifier.scopusauthoridYanQin, G=6505535224en_US
dc.identifier.scopusauthoridYan, L=35079825600en_US
dc.identifier.scopusauthoridZhiXiong, L=55287257500en_US
dc.identifier.scopusauthoridNg, MH=7202076421en_US

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