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Article: Pre-operative parenteral nutrition in patients with oesophageal cancer: a prospective, randomised clinical trial

TitlePre-operative parenteral nutrition in patients with oesophageal cancer: a prospective, randomised clinical trial
Authors
Issue Date1989
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/clnu
Citation
Clinical Nutrition, 1989, v. 8 n. 1, p. 23-27 How to Cite?
AbstractA prospective randomised clinical trial was conducted to examine the efficacy of 2 weeks pre-operative parenteral nutrition (PPN) for the prevention of complications following surgery for oesophageal cancer. Forty patients were studied, the diet of twenty being supplemented by pre-operative parenteral nutrition. There were no significant differences in age, nutritional status, tumour staging and histology between the two groups of patients. The use of PPN resulted in a significant gain in body weight and nitrogen but failed to produce an overall reduction in post-operative morbidity and mortality rates. However patients receiving PPN exhibited two types of changes in serum albumin levels. Those with a fall in serum albumin levels associated with an increase in body weight (indicating an expansion of extracellular volume) had a significantly higher incidence of post-operative pulmonary complications than the group exhibiting a rise in serum albumin levels concomitant with increase in body weight. These data suggested that two weeks PPN might not be adequate in certain patients and a longer period of PPN is required. They also show no clinical benefit from the routine use of pre-operative parenteral nutrition in all patients, but do not exclude benefit in selected groups.
Persistent Identifierhttp://hdl.handle.net/10722/172603
ISSN
2015 Impact Factor: 4.487
2015 SCImago Journal Rankings: 1.704

 

DC FieldValueLanguage
dc.contributor.authorFan, STen_US
dc.contributor.authorLau, WYen_US
dc.contributor.authorWong, KKen_US
dc.contributor.authorChan, YPMen_US
dc.date.accessioned2012-10-30T06:23:41Z-
dc.date.available2012-10-30T06:23:41Z-
dc.date.issued1989en_US
dc.identifier.citationClinical Nutrition, 1989, v. 8 n. 1, p. 23-27en_US
dc.identifier.issn0261-5614en_US
dc.identifier.urihttp://hdl.handle.net/10722/172603-
dc.description.abstractA prospective randomised clinical trial was conducted to examine the efficacy of 2 weeks pre-operative parenteral nutrition (PPN) for the prevention of complications following surgery for oesophageal cancer. Forty patients were studied, the diet of twenty being supplemented by pre-operative parenteral nutrition. There were no significant differences in age, nutritional status, tumour staging and histology between the two groups of patients. The use of PPN resulted in a significant gain in body weight and nitrogen but failed to produce an overall reduction in post-operative morbidity and mortality rates. However patients receiving PPN exhibited two types of changes in serum albumin levels. Those with a fall in serum albumin levels associated with an increase in body weight (indicating an expansion of extracellular volume) had a significantly higher incidence of post-operative pulmonary complications than the group exhibiting a rise in serum albumin levels concomitant with increase in body weight. These data suggested that two weeks PPN might not be adequate in certain patients and a longer period of PPN is required. They also show no clinical benefit from the routine use of pre-operative parenteral nutrition in all patients, but do not exclude benefit in selected groups.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/clnuen_US
dc.relation.ispartofClinical Nutritionen_US
dc.titlePre-operative parenteral nutrition in patients with oesophageal cancer: a prospective, randomised clinical trialen_US
dc.typeArticleen_US
dc.identifier.emailFan, ST: stfan@hku.hken_US
dc.identifier.authorityFan, ST=rp00355en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0024502773en_US
dc.identifier.volume8en_US
dc.identifier.issue1en_US
dc.identifier.spage23en_US
dc.identifier.epage27en_US
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridFan, ST=7402678224en_US
dc.identifier.scopusauthoridLau, WY=7402933199en_US
dc.identifier.scopusauthoridWong, KK=7404759210en_US
dc.identifier.scopusauthoridChan, YPM=14009821700en_US

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