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Article: Once daily administration of netilmicin compared with thrice daily, both in combination with metronidazole, in gangrenous and perforated appendicitis

TitleOnce daily administration of netilmicin compared with thrice daily, both in combination with metronidazole, in gangrenous and perforated appendicitis
Authors
Issue Date1988
PublisherOxford University Press. The Journal's web site is located at http://jac.oxfordjournals.org/
Citation
Journal Of Antimicrobial Chemotherapy, 1988, v. 22 n. 1, p. 69-74 How to Cite?
AbstractThe safety and efficacy of a single daily dose of netilmicin plus metronidazole after appendicectomy for gangrenous and perforated appendicitis was compared with the traditional thrice daily dosage. Twenty patients were enrolled in each group. The antibiotics were given intramuscularly for seven days after operation. Eradication of infection was observed in all patients and the postoperative wound sepsis was the same for each group. A significantly higher peak serum netilmicin level was achieved in the group receiving a single daily dose but nephrotoxicity was not observed. We concluded that the single daily dose of netilmicin was well tolerated and was as efficacious in this small series as the thrice daily regimen. The single-dose regimen has the advantage of simplicity and potentially increased bactericidal activity.
Persistent Identifierhttp://hdl.handle.net/10722/172576
ISSN
2015 Impact Factor: 4.919
2015 SCImago Journal Rankings: 2.157
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFan, STen_US
dc.contributor.authorLau, WYen_US
dc.contributor.authorTeohChan, CHen_US
dc.contributor.authorLau, KFen_US
dc.contributor.authorMauracher, EHen_US
dc.date.accessioned2012-10-30T06:23:30Z-
dc.date.available2012-10-30T06:23:30Z-
dc.date.issued1988en_US
dc.identifier.citationJournal Of Antimicrobial Chemotherapy, 1988, v. 22 n. 1, p. 69-74en_US
dc.identifier.issn0305-7453en_US
dc.identifier.urihttp://hdl.handle.net/10722/172576-
dc.description.abstractThe safety and efficacy of a single daily dose of netilmicin plus metronidazole after appendicectomy for gangrenous and perforated appendicitis was compared with the traditional thrice daily dosage. Twenty patients were enrolled in each group. The antibiotics were given intramuscularly for seven days after operation. Eradication of infection was observed in all patients and the postoperative wound sepsis was the same for each group. A significantly higher peak serum netilmicin level was achieved in the group receiving a single daily dose but nephrotoxicity was not observed. We concluded that the single daily dose of netilmicin was well tolerated and was as efficacious in this small series as the thrice daily regimen. The single-dose regimen has the advantage of simplicity and potentially increased bactericidal activity.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://jac.oxfordjournals.org/en_US
dc.relation.ispartofJournal of Antimicrobial Chemotherapyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAppendicitis - Drug Therapyen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMetronidazole - Administration & Dosageen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNetilmicin - Administration & Dosageen_US
dc.subject.meshRandom Allocationen_US
dc.titleOnce daily administration of netilmicin compared with thrice daily, both in combination with metronidazole, in gangrenous and perforated appendicitisen_US
dc.typeArticleen_US
dc.identifier.emailFan, ST: stfan@hku.hken_US
dc.identifier.authorityFan, ST=rp00355en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/jac/22.1.69-
dc.identifier.pmid3170392-
dc.identifier.scopuseid_2-s2.0-0023753212en_US
dc.identifier.volume22en_US
dc.identifier.issue1en_US
dc.identifier.spage69en_US
dc.identifier.epage74en_US
dc.identifier.isiWOS:A1988P301400009-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridFan, ST=7402678224en_US
dc.identifier.scopusauthoridLau, WY=7402933199en_US
dc.identifier.scopusauthoridTeohChan, CH=6603360891en_US
dc.identifier.scopusauthoridLau, KF=7401560107en_US
dc.identifier.scopusauthoridMauracher, EH=6602760028en_US

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