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Article: Combined topical povidone-iodine and systemic antibiotics in postappendicectomy wound sepsis

TitleCombined topical povidone-iodine and systemic antibiotics in postappendicectomy wound sepsis
Authors
Issue Date1986
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.bjs.co.uk
Citation
British Journal Of Surgery, 1986, v. 73 n. 12, p. 958-960 How to Cite?
AbstractThree hundred and fifteen patients with appendicitis were randomized into two groups. One group received pre-operative systemic gentamicin and metronidazole while the other gruop received 1 per cent topical povidone-iodine solution in addition to the antibiotics. For early appendicitis including normal and acutely inflamed appendices, only one dose of antibiotics was used. The postoperative wound sepsis was very low in both groups of patients and there was no statistical difference between them. For late appendicitis including gangrenous and perforated appendices, the antibiotics were continued for 7 days. Eight out of 51 patients who had the topical agent developed wound sepsis compared with one out of 52 patients who received no topical agent. This difference is statistically significant (P=0.03). All wound infections presented within 2 weeks of operation and were deep. Povidone-iodine, 1 per cent, adversely affects the wound infection rate in late appendicitis and should not be used.
Persistent Identifierhttp://hdl.handle.net/10722/172552
ISSN
2015 Impact Factor: 5.596
2015 SCImago Journal Rankings: 2.966
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, WYen_US
dc.contributor.authorFan, STen_US
dc.contributor.authorChu, KWen_US
dc.date.accessioned2012-10-30T06:23:22Z-
dc.date.available2012-10-30T06:23:22Z-
dc.date.issued1986en_US
dc.identifier.citationBritish Journal Of Surgery, 1986, v. 73 n. 12, p. 958-960en_US
dc.identifier.issn0007-1323en_US
dc.identifier.urihttp://hdl.handle.net/10722/172552-
dc.description.abstractThree hundred and fifteen patients with appendicitis were randomized into two groups. One group received pre-operative systemic gentamicin and metronidazole while the other gruop received 1 per cent topical povidone-iodine solution in addition to the antibiotics. For early appendicitis including normal and acutely inflamed appendices, only one dose of antibiotics was used. The postoperative wound sepsis was very low in both groups of patients and there was no statistical difference between them. For late appendicitis including gangrenous and perforated appendices, the antibiotics were continued for 7 days. Eight out of 51 patients who had the topical agent developed wound sepsis compared with one out of 52 patients who received no topical agent. This difference is statistically significant (P=0.03). All wound infections presented within 2 weeks of operation and were deep. Povidone-iodine, 1 per cent, adversely affects the wound infection rate in late appendicitis and should not be used.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.bjs.co.uken_US
dc.relation.ispartofBritish Journal of Surgeryen_US
dc.subject.meshAdministration, Topicalen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnti-Bacterial Agents - Therapeutic Useen_US
dc.subject.meshAppendectomyen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshGentamicins - Therapeutic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshMetronidazole - Therapeutic Useen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPovidone - Analogs & Derivativesen_US
dc.subject.meshPovidone-Iodine - Therapeutic Useen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshSurgical Wound Infection - Drug Therapy - Prevention & Controlen_US
dc.titleCombined topical povidone-iodine and systemic antibiotics in postappendicectomy wound sepsisen_US
dc.typeArticleen_US
dc.identifier.emailFan, ST: stfan@hku.hken_US
dc.identifier.authorityFan, ST=rp00355en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/bjs.1800731205-
dc.identifier.pmid3790957-
dc.identifier.scopuseid_2-s2.0-0023032346en_US
dc.identifier.volume73en_US
dc.identifier.issue12en_US
dc.identifier.spage958en_US
dc.identifier.epage960en_US
dc.identifier.isiWOS:A1986F232500004-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLau, WY=7402933199en_US
dc.identifier.scopusauthoridFan, ST=7402678224en_US
dc.identifier.scopusauthoridChu, KW=16026609700en_US

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