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Article: Prophylaxis of postappendicectomy sepsis by metronidazole and cefotaxime; a randomized, prospective and double blind trial

TitleProphylaxis of postappendicectomy sepsis by metronidazole and cefotaxime; a randomized, prospective and double blind trial
Authors
Issue Date1983
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.bjs.co.uk
Citation
British Journal Of Surgery, 1983, v. 70 n. 11, p. 670-672 How to Cite?
AbstractA randomized, prospective and double blind trial was conducted on 308 patients. Thirty-one out of 102 patients receiving metronidazole developed wound infection compared with 13 out of 103 patients receiving cefotaxime and 14 out of 103 patients receiving metronidazole and cefotaxime. The reduction in the wound sepsis by the use of cefotaxime or a combination of metronidazole and cefotaxime was statistically significant when compared with patients who received metronidazole only. For early cases including normal, acutely inflamed and gangrenous appendices, we gave a single dose of antibiotics just before operation. For late cases with perforation and abscess formation, the antibiotics were continued for 5 days. There was no statistical difference in wound infection between patients who received cefotaxime alone and these who received a combination of metronidazole and cefotaxime.
Persistent Identifierhttp://hdl.handle.net/10722/172524
ISSN
2015 Impact Factor: 5.596
2015 SCImago Journal Rankings: 2.966
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, WYen_US
dc.contributor.authorFan, STen_US
dc.contributor.authorYiu, TFen_US
dc.date.accessioned2012-10-30T06:23:14Z-
dc.date.available2012-10-30T06:23:14Z-
dc.date.issued1983en_US
dc.identifier.citationBritish Journal Of Surgery, 1983, v. 70 n. 11, p. 670-672en_US
dc.identifier.issn0007-1323en_US
dc.identifier.urihttp://hdl.handle.net/10722/172524-
dc.description.abstractA randomized, prospective and double blind trial was conducted on 308 patients. Thirty-one out of 102 patients receiving metronidazole developed wound infection compared with 13 out of 103 patients receiving cefotaxime and 14 out of 103 patients receiving metronidazole and cefotaxime. The reduction in the wound sepsis by the use of cefotaxime or a combination of metronidazole and cefotaxime was statistically significant when compared with patients who received metronidazole only. For early cases including normal, acutely inflamed and gangrenous appendices, we gave a single dose of antibiotics just before operation. For late cases with perforation and abscess formation, the antibiotics were continued for 5 days. There was no statistical difference in wound infection between patients who received cefotaxime alone and these who received a combination of metronidazole and cefotaxime.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.bjs.co.uken_US
dc.relation.ispartofBritish Journal of Surgeryen_US
dc.subject.meshAppendectomyen_US
dc.subject.meshBacteria, Aerobic - Isolation & Purificationen_US
dc.subject.meshBacteria, Anaerobic - Isolation & Purificationen_US
dc.subject.meshCefotaxime - Therapeutic Useen_US
dc.subject.meshChilden_US
dc.subject.meshClinical Trials As Topicen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshHumansen_US
dc.subject.meshMetronidazole - Therapeutic Useen_US
dc.subject.meshPremedicationen_US
dc.subject.meshSurgical Wound Infection - Microbiology - Prevention & Controlen_US
dc.subject.meshTime Factorsen_US
dc.titleProphylaxis of postappendicectomy sepsis by metronidazole and cefotaxime; a randomized, prospective and double blind trialen_US
dc.typeArticleen_US
dc.identifier.emailFan, ST: stfan@hku.hken_US
dc.identifier.authorityFan, ST=rp00355en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/bjs.1800701110-
dc.identifier.pmid6315120-
dc.identifier.scopuseid_2-s2.0-0021026837en_US
dc.identifier.volume70en_US
dc.identifier.issue11en_US
dc.identifier.spage670en_US
dc.identifier.epage672en_US
dc.identifier.isiWOS:A1983RU05100008-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLau, WY=7402933199en_US
dc.identifier.scopusauthoridFan, ST=7402678224en_US
dc.identifier.scopusauthoridYiu, TF=36887055400en_US

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